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Categories: Biology: Biotechnology, Geoscience: Oceanography
Published Elucidating the mysteries of enzyme evolution at the macromolecular level
(via sciencedaily.com) Original source Researchers have made a major breakthrough earlier this year in the field of evolutionary conservation of molecular dynamics in enzymes. Their work points to potential applications in health, including the development of new drugs to treat serious diseases such as cancer or to counter antibiotic resistance.
Published Scientist uncovers roots of antibiotic resistance
(via sciencedaily.com) Original source Microbiologists have uncovered the evolutionary origins of antimicrobial resistance (AMR) in bacteria. His studies on the bacterium that causes cholera, Vibrio cholerae, provide insight into deciphering what conditions must occur for infectious agents to become resistant. He studied genetic variants of a protein found in bacterial membranes called OmpU. Using computational and molecular approaches, his team found that several OmpU mutations in the cholera bacteria led to resistance to numerous antimicrobial agents. This resistance included antimicrobial peptides that act as defenses in the human gut.
Published Gutless marine worms on a Mediterranean diet: Animals can synthesize phytosterols
(via sciencedaily.com) Original source Phytosterols are good for your health, but humans and other animals are not able to make them themselves, only plants can. To acquire phytosterols, humans are increasingly turning to supplements, green smoothies, or a Mediterranean diet with plenty of plant-based foods. Researchers have now discovered that tiny gutless worms from the Mediterranean can synthesize phytosterols on their own. Their study provides evidence that many other animals also have the genes needed to make their own phytosterols.
Published Scientists begin to unravel global role of atmospheric dust in nourishing oceans
(via sciencedaily.com) Original source New research begins to unravel the role dust plays in nourishing global ocean ecosystems while helping regulate atmospheric carbon dioxide levels.
Published Alternative 'fuel' for string-shaped motors in cells
(via sciencedaily.com) Original source Researchers discover a unique two-component molecular motor that uses a kind of renewable chemical energy to pull vesicles toward membrane-bound organelles.
Published Scientists recover an ancient woman's DNA from a 20,000-year-old pendant
(via sciencedaily.com) Original source An international research team has for the first time successfully isolated ancient human DNA from a Paleolithic artefact: a pierced deer tooth discovered in Denisova Cave in southern Siberia. To preserve the integrity of the artefact, they developed a new, nondestructive method for isolating DNA from ancient bones and teeth. From the DNA retrieved they were able to reconstruct a precise genetic profile of the woman who used or wore the pendant, as well as of the deer from which the tooth was taken. Genetic dates obtained for the DNA from both the woman and the deer show that the pendant was made between 19,000 and 25,000 years ago. The tooth remains fully intact after analysis, providing testimony to a new era in ancient DNA research, in which it may become possible to directly identify the users of ornaments and tools produced in the deep past.
Published Indo-Pacific corals more resilient to climate change than Atlantic corals
(via sciencedaily.com) Original source In the face of global warming and other environmental changes, corals in the Atlantic Ocean have declined precipitously in recent years, while corals in the Pacific and Indian Oceans are faring better. By describing several species of symbiotic algae that these corals need to grow, an international team has found that these mutualistic relationships from the Indo-Pacific may be more flexible and ultimately resilient to higher ocean temperatures than those in the Atlantic.
Published A novel stem cell adhesive using mussels
(via sciencedaily.com) Original source A team of researchers develops stem cell adhesive for arthritis treatment using mussel adhesion protein and hyaluronic acid.
Published Chances of eliminating HIV infection increased by novel dual gene-editing approach
(via sciencedaily.com) Original source Gene-editing therapy aimed at two targets -- HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells -- can effectively eliminate HIV infection, new research shows. The study combines a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1.
Published Scientists present evidence for a billion-years arms race between viruses and their hosts
(via sciencedaily.com) Original source Researchers have proposed a new evolutionary model for the origin of a kingdom of viruses called Bamfordvirae, suggesting a billion-years evolutionary arms race between two groups within this kingdom and their hosts.
Published Wiggly proteins guard the genome
(via sciencedaily.com) Original source Dynamic network in the pores of the nuclear envelope blocks dangerous invaders.
Published West Antarctic Ice Sheet retreated far inland, re-advanced since last Ice Age
(via sciencedaily.com) Original source The West Antarctic Ice Sheet is melting rapidly, raising concerns it could cross a tipping point of irreversible retreat in the next few decades if global temperatures rise 1.5 to 2.0 degrees Celsius (2.7 to 3.8 degrees Fahrenheit) above preindustrial levels. New research finds that 6,000 years ago, the grounded edge of the ice sheet may have been as far as 250 kilometers (160 miles) inland from its current location, suggesting the ice retreated deep into the continent after the end of the last ice age and re-advanced before modern retreat began.
Published Herpes study adds to understanding of viral reinfections, how to potentially prevent them
(via sciencedaily.com) Original source A new study on herpes infections of the eye helps shed light on the question of viral reinfections by identifying a key protein involved in viral reinfections that could be targeted by antiviral drugs.
Published Scientists identify antivirals that could combat emerging infectious diseases
(via sciencedaily.com) Original source A new study has identified potential broad-spectrum antiviral agents that can target multiple families of RNA viruses that continue to pose a significant threat for future pandemics.
Published The future is foggy for Arctic shipping
(via sciencedaily.com) Original source As the Arctic warms and loses sea ice, trans-Arctic shipping has increased, reducing travel time and costs for international trade. However, a new study finds that the Arctic Ocean is getting foggier as ice disappears, reducing visibility and causing costly delays as ships slow to avoid hitting dangerous sea ice.
Published Scientists slow aging by engineering longevity in cells
(via sciencedaily.com) Original source Researchers have developed a biosynthetic 'clock' that keeps cells from reaching normal levels of deterioration related to aging. They engineered a gene oscillator that switches between the two normal paths of aging, slowing cell degeneration and setting a record for life extension.
Published Pulling the plug on viral infections: CRISPR isn't just about cutting
(via sciencedaily.com) Original source CRISPR claimed scientific fame for its ability to quickly and accurately edit genes. But, at the core, CRISPR systems are immune systems that help bacteria protect themselves from viruses. A new study reveals a previously unrecognized player in one such system -- a membrane protein that enhances anti-viral defense. According to study authors, the finding upends the idea that CRISPR systems mount their defense only by degrading RNA and DNA in cells.
Published Information 'deleted' from the human genome may be what made us human
(via sciencedaily.com) Original source What the human genome is lacking compared with the genomes of other primates might have been as crucial to the development of humankind as what has been added during our evolutionary history, according to a new study led by researchers at Yale and the Broad Institute of MIT and Harvard. The new findings, published April 28 in the journal Science, fill an important gap in what is known about historical changes to the human genome.
Published Mammalian evolution provides hints for understanding the origins of human disease
(via sciencedaily.com) Original source Even though it is important to know where these variations are located in the genome, it's also useful to know how or why these genetic variations happened in the first place.
Published Male California sea lions are becoming bigger and better fighters as their population rebounds
(via sciencedaily.com) Original source California sea lions have managed to maintain -- and, in the case of males, increase -- their average body size as their population grows and competition for food becomes fiercer. This is in contrast to other marine mammals, whose average body size tends to decrease as their numbers increase. Researchers report that sexual selection was a strong driving force for males to grow bigger and to strengthen muscles in their neck and jaw that help them fight for mates. Both male and female sea lions evaded food shortages by diversifying their diets and, in some cases, foraging further from the shore.