Showing 20 articles starting at article 441
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Categories: Biology: Biotechnology, Geoscience: Oceanography
Published New method reveals hidden activity of life below ground
(via sciencedaily.com) Original source Researchers have refined an innovative method for measuring the activity level of microbes and linking that to their individual genetic code, providing new insights into the microbial communities that thrive in extreme environments.
Published New antibiotic class effective against multidrug-resistant bacteria
(via sciencedaily.com) Original source Scientists have discovered a new class of antibiotics with potent activity against multi-drug resistant bacteria, and have shown that it cures bloodstream infections in mice. Two publicly-funded initiatives dedicated to advancing early-stage antibiotic development, ENABLE and ENABLE-2, provided the resources and expert support without which this antibiotic would not have been developed.
Published Pilot study shows ketogenic diet improves severe mental illness
(via sciencedaily.com) Original source A small clinical trial found that the metabolic effects of a ketogenic diet may help stabilize the brain.
Published When inequality is more than 'skin-deep': Social status leaves traces in the epigenome of spotted hyenas in Tanzania
(via sciencedaily.com) Original source A research consortium provides evidence that social behavior and social status are reflected at the molecular level of gene activation (epigenome) in juvenile and adult free-ranging spotted hyenas. They analyzed non-invasively collected gut epithelium samples from both high-ranking and low-ranking female hyenas and showed that rank differences were associated with epigenetic signatures of social inequality, i.e., the pattern of activation or switching off of genes that regulate important physiological processes such as energy conversion and immune response in several genome regions.
Published How the Crimean-Congo hemorrhagic fever virus enters our cells
(via sciencedaily.com) Original source Researchers have identified how the tick-borne Crimean-Congo haemorrhagic fever virus enters our cells. The results are an important step in the development of drugs against the deadly disease.
Published Genomic research may help explain cancer resistance in Tasmanian devils
(via sciencedaily.com) Original source Through DNA sequencing of Tasmanian devils and their tumors, researchers have tracked the genomic interactions between the animals and the cancer.
Published Researchers discover key gene for toxic alkaloid in barley
(via sciencedaily.com) Original source Barley is one of the most important cereal crops on a global scale. Many barley cultivars produce a toxic alkaloid called gramine that affects the suitability of barley as fodder, but also helps to protect barley from pathogens. So far, the potential of manipulating gramine levels has not been harnessed for plant breeding, because the genetic basis of gramine production has been unresolved. Research groups now disclose the complete biosynthetic pathway of gramine and demonstrate how gramine biosynthesis can be introduced into model organisms or removed from barley.
Published Connecting the dots to shape growth forces
(via sciencedaily.com) Original source Branching patterns are prevalent in our natural environment and the human body, such as in the lungs and kidneys. For example, specific genes that express growth factor proteins are known to influence the development of the lungs' complex branches. Researchers have unveiled a regulatory system linking signal, force, and shape in mouse lung structure development. The team recognized that the signal protein ERK plays an active role in causing growing lung tissue to curve.
Published Synaptic protein change during development offers clues on evolution and disease
(via sciencedaily.com) Original source An analysis of how synaptic proteins change during early development reveals differences between mice and marmosets but also what's different in individuals with autism spectrum disorders. The findings offer first insights into the mechanism behind synaptic development and open up routes for research on possible treatments.
Published How extratropical ocean-atmosphere interactions can contribute to the variability of jet streams in the Northern Hemisphere
(via sciencedaily.com) Original source Ocean-atmosphere coupling, the exchange in energy between the ocean and atmosphere, influences teleconnection patterns, the climate effects across vast geographical areas. However, its impact outside the tropics is unclear. A group of researchers examined the effect of ocean coupling on atmospheric circulation patterns in the Northern Hemisphere. They found that extratropical ocean-atmosphere coupling enhances teleconnection patterns and causes more meandering westerly jet streams, which are linked to extreme weather events.
Published Artificial reef designed by MIT engineers could protect marine life, reduce storm damage
(via sciencedaily.com) Original source Engineers designed an 'architected' reef that can mimic the wave-buffering effects of natural reefs while providing pockets for marine life. The sustainable and cost-saving structure could dissipate more than 95 percent of incoming wave energy using a small fraction of the material normally needed.
Published A combination of approved drugs enhances the delivery of anti-bacterial medications to treat tuberculosis
(via sciencedaily.com) Original source Researchers have found that approved drugs that were originally shown to normalize blood vessels surrounding tumors (to improve drug delivery to cancer cells) can enhance the delivery of anti-microbial medications to kill tuberculosis bacteria residing in the lungs.
Published Sweet success: Sugarcane's complex genetic code cracked
(via sciencedaily.com) Original source Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants. Exploring sugarcane's genetic code could help researchers develop more resilient and productive crops, with implications for both sugar production and biofuels.
Published Scientists extract genetic secrets from 4,000-year-old teeth to illuminate the impact of changing human diets over the centuries
(via sciencedaily.com) Original source Researchers have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.
Published New technique for predicting protein dynamics may prove big breakthrough for drug discovery
(via sciencedaily.com) Original source Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them. To that end, a team of researchers has developed a way of using machine learning to rapidly predict multiple protein configurations to advance understanding of protein dynamics and functions.
Published New enzymatic cocktail can kill tuberculosis-causing mycobacteria
(via sciencedaily.com) Original source An enzymatic cocktail can kill a variety of mycobacterial species of bacteria, including those that cause tuberculosis.
Published Old immune systems revitalized in mouse study, improving vaccine response
(via sciencedaily.com) Original source Those with aging immune systems struggle to fight off novel viruses and respond weakly to vaccination. Researchers were able to revitalize the immune system in mice.
Published Evolution of the most powerful ocean current on Earth
(via sciencedaily.com) Original source The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica's ice sheets. An international research team has now used sediments taken from the South Pacific to reconstruct the flow speed in the last 5.3 million years. Their data show that during glacial periods, the current slowed; during interglacials, it accelerated. Consequently, if the current global warming intensifies in the future, it could mean that the Southern Ocean stores less CO2 and that more heat reaches Antarctica.
Published Researchers show that introduced tardigrade proteins can slow metabolism in human cells
(via sciencedaily.com) Original source Tardigrade proteins are potential candidates in technologies centered on slowing the aging process and in long-term storage of human cells.
Published Severe hurricanes boost influx of juveniles and gene flow in a coral reef sponge
(via sciencedaily.com) Original source A study is the first to evaluate substrate recolonization by sponges in the U.S. Virgin Islands after two catastrophic storms using genetic analyses to understand how much clonality verses sexual recruitment occurs on coral reefs post-storms. Results show that populations of clonal marine species with low pelagic dispersion, such as A. cauliformis, may benefit from increased frequency and magnitude of hurricanes to maintain genetic diversity and combat inbreeding, enhancing the resilience of Caribbean sponge communities to extreme storm events.