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Categories: Biology: Biotechnology, Geoscience: Oceanography
Published DNA origami-based vaccines toward safe and highly-effective precision cancer immunotherapy
(via sciencedaily.com) Original source Researchers have created a DNA origami platform called DoriVac, whose core component is a self-assembling square block-shaped nanostructure. DoriVac vaccines enabled tumor-bearing mice to better control the growth of tumors and to survive significantly longer than control mice.
Published Protein fragments ID two new 'extremophile' microbes--and may help find alien life
(via sciencedaily.com) Original source Perfectly adapted microorganisms live in extreme environments from deep-sea trenches to mountaintops. Learning more about how these extremophiles survive in hostile conditions could inform scientists about life on Earth and potential life on other planets.
Published Shark-bitten orcas in the Northeastern Pacific could be a new population of killer whale
(via sciencedaily.com) Original source Researchers believe a group of killer whales observed hunting marine mammals including sperm whales, as well as a sea turtle, in the open ocean off California and Oregon could be a new population. Based on available evidence, the researchers posit that the 49 orcas could belong to a subpopulation of transient killer whales or a unique oceanic population found in waters off the coast of California and Oregon.
Published Breakthrough could make automated dosing systems universal
(via sciencedaily.com) Original source Automated insulin dosing systems combine low-cost blood-glucose monitors with insulin pumps that use precision dosing to continuously regulate blood-sugar and hold it steady. Synthetic biologists have found a way to piggyback on the technology and make it universally applicable for the precision dosing of virtually any drug.
Published Groundbreaking study reveals extensive leatherback turtle activity along U.S. coastline
(via sciencedaily.com) Original source A new study provides groundbreaking findings that offer insights on the migration and foraging patterns of leatherback sea turtles along the Northwest Atlantic shelf.
Published New study on mating behaviors offers clues into the evolution of attraction
(via sciencedaily.com) Original source In examining the mating rituals of roundworms, researchers uncovered a unique approach to reproduction that maximizes genetic fitness.
Published It's hearty, it's meaty, it's mold
(via sciencedaily.com) Original source Scientists are exploring how tuning the genomes of mushrooms and molds can transform these food sources into gourmet, nutrient-packed meals made with minimal processing and a light environmental footprint.
Published Alzheimer's drug fermented with help from AI and bacteria moves closer to reality
(via sciencedaily.com) Original source Researchers combined artificial intelligence and chemical biosensors to ferment the precursor of an Alzheimer's drug in bacteria.
Published New bioengineered protein design shows promise in fighting COVID-19
(via sciencedaily.com) Original source A recent scientific breakthrough has emerged from the work of researchers aiming to combat SARS-CoV-2, the virus responsible for COVID-19. The study focuses on the design and development of a novel protein capable of binding to the spike proteins found on the surface of the coronavirus. The goal behind this innovative approach is twofold: first, to identify and recognize the virus for diagnostic purposes, and second, to hinder its ability to infect human cells.
Published Even cells know the importance of recycling
(via sciencedaily.com) Original source Researchers uncovered the mechanistic details behind how several proteins interact to help cells recognize and remove damaged mitochondria. Optineurin (OPTN) and its interactions are needed to provide a contact site for another protein, Tank-binding kinase 1 (TBK1), during this process. The OPTN-TBK1 relationship is necessary for these mitochondria to be recognized and eliminated from the cell. This mechanism may have relevance for developing drugs to treat Parkinson's disease.
Published New simpler and cost-effective forensics test helps identify touch DNA
(via sciencedaily.com) Original source Research has found a less expensive and easier to use test to learn more about forensic touch DNA. This research has important implications for forensic investigations and being able to identify DNA from a primary contact -- someone who may have committed the crime -- as well as secondary DNA that was inadvertently and indirectly transferred through touch.
Published With discovery of roundworms, Great Salt Lake's imperiled ecosystem gets more interesting
(via sciencedaily.com) Original source Biologists announce the discovery of numerous species of roundworm in the highly saline waters of Great Salt Lake, the vast terminal lake in northwestern Utah that supports millions of migratory birds. Previously, brine shrimp and brine flies were the only known multicellular animals living in the water column. The scientists found nematodes, belonging to a family known for inhabiting extreme environments, in the lake's microbialites, reef-like structures covering about a fifth of the lakebed.
Published Marine heat waves disrupt the ocean food web in the northeast Pacific Ocean
(via sciencedaily.com) Original source Marine heat waves in the northeast Pacific Ocean create ongoing and complex disruptions of the ocean food web that may benefit some species but threaten the future of many others, a new study has shown.
Published Steroid drugs used for HRT can combat E. coli and MRSA
(via sciencedaily.com) Original source Researchers have combined computational and microbiology laboratory approaches to identify existing drugs that can be repurposed to combat antibiotic-resistant bacterial infections. This research has revealed that a class of steroid drugs currently used in hormone replacement therapy (HRT) can also stop the growth of antibiotic-resistant E. coli and effectively kill MRSA.
Published New computational strategy boosts the ability of drug designers to target proteins inside the membrane
(via sciencedaily.com) Original source Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, chemists have demonstrated new custom-designed proteins that can efficiently reach these 'intramembrane' targets.
Published Researchers develop a new control method that optimizes autonomous ship navigation
(via sciencedaily.com) Original source Existing ship control systems using Model Predictive Control for Maritime Autonomous Surface Ships (MASS) do not consider the various forces acting on ships in real sea conditions. Addressing this gap, researchers developed a novel time-optimal control method, that accounts for the real wave loads acting on a ship, enabling effective planning and control of MASS at sea.
Published Simple trick could improve accuracy of plant genetics research
(via sciencedaily.com) Original source Researchers have published a simple trick that improves the accuracy of techniques that help us understand how external variables -- such as temperature -- affect gene activity in plants.
Published Milk to the rescue for diabetics? Cow produces human insulin in milk
(via sciencedaily.com) Original source An unassuming brown bovine from the south of Brazil has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes.
Published Grounding zone discovery explains accelerated melting under Greenland's glaciers
(via sciencedaily.com) Original source Researchers have conducted the first large-scale observation and modeling study of northwest Greenland's Petermann Glacier. Their findings reveal the intrusion of warm ocean water beneath the ice as the culprit in the accelerated melting it has experienced since the turn of the century, and their computer predictions indicate that potential sea level rise will be much worse than previously estimated.
Published A simple and robust experimental process for protein engineering
(via sciencedaily.com) Original source A protein engineering method using simple, cost-effective experiments and machine learning models can predict which proteins will be effective for a given purpose, according to a new study.