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Categories: Biology: Biotechnology, Geoscience: Oceanography
Published An awkward family reunion: Sea monsters are our cousins
(via sciencedaily.com) Original source The sea lamprey, a 500-million-year-old animal with a sharp-toothed suction cup for a mouth, is the thing of nightmares. A new study discovered that the hindbrain -- the part of the brain controlling vital functions like blood pressure and heart rate -- of both sea lampreys and humans is built using an extraordinarily similar molecular and genetic toolkit.
Published Mercury levels in tuna remain nearly unchanged since 1971
(via sciencedaily.com) Original source Tuna is one of the most popular seafoods worldwide. But this protein-rich fish can build up high levels of methylmercury from feeding on contaminated prey, like smaller fish or crustaceans. Despite efforts to reduce mercury emissions into the environment, researchers report that levels in tuna appear to be unchanged since 1971. They warn that more aggressive emission reduction targets are needed to start nudging down tuna mercury levels.
Published Compounds in female ginseng could lead to new osteoporosis treatments
(via sciencedaily.com) Original source With ever-increasing life expectancy comes the challenge of treating age-related disorders such as osteoporosis. Although there are effective drugs for treating this metabolic bone disease, they can be expensive and have side effects, limiting their availability to some people. In the search for alternative drug candidates, researchers have discovered and fully replicated a compound from a botanical source, female ginseng, that had potent anti-osteoporotic activity in cellular tests.
Published New system triggers cellular waste disposal
(via sciencedaily.com) Original source Established treatments for cancer and other diseases often focus on inhibiting harmful enzymes to mitigate their effects. However, a more innovative approach has emerged: harnessing the cell's natural waste disposal system not just to deactivate but to entirely eradicate these proteins. Researchers have previously demonstrated the efficacy of this approach through two distinct methods. Now they unveil a third system capable of targeting and disposing of previously inaccessible proteins.
Published Detecting pathogens faster and more accurately by melting DNA
(via sciencedaily.com) Original source A new analysis method can detect pathogens in blood samples faster and more accurately than blood cultures, which are the current state of the art for infection diagnosis. The new method, called digital DNA melting analysis, can produce results in under six hours, whereas culture typically requires 15 hours to several days, depending on the pathogen.
Published Gulf corals still suffering more than a decade after Deepwater Horizon oil spill, scientists report
(via sciencedaily.com) Original source Deep-water corals in the Gulf of Mexico are still struggling to recover from the devastating Deepwater Horizon oil spill in 2010, scientists report at the Ocean Science Meeting in New Orleans. Comparing images of more than 300 corals over 13 years -- the longest time series of deep-sea corals to date -- reveals that in some areas, coral health continues to decline to this day.
Published Breakthrough in developing the PD-1-enhanced DNA vaccine for over 6-year cART-free AIDS prevention and virologic control
(via sciencedaily.com) Original source Researchers found that PD-1-enhanced DNA vaccination can induce sustained virus-specific CD8+ T cell immunity in an AIDS monkey model. The vaccinated monkeys remained free of AIDS for six years and achieved virologic control without the need for combination antiretroviral therapy (cART), a treatment used to suppress viral replication in individuals living with human immunodeficiency virus (HIV). The study also found that polyfunctional and broadly reactive effector-memory virus-specific T cells were maintained in the protected experimental macaques for over six years. The findings provide supporting evidence that the PD-1-enhanced DNA vaccine strategy holds promise as a third-generation DNA vaccine for AIDS prevention and immunotherapy.
Published Researchers are using RNA in a new approach to fight HIV
(via sciencedaily.com) Original source A pharmacy associate professor has developed a novel nanomedicine loaded with genetic material called small interfering RNAs (siRNA) to fight human immunodeficiency virus (HIV) using gene therapy.
Published New model identifies drugs that shouldn't be taken together
(via sciencedaily.com) Original source Researchers have developed a multipronged strategy to identify the transporters used by different drugs. Their approach, which makes use of both tissue models and machine-learning algorithms, has already revealed that a commonly prescribed antibiotic and a blood-thinner can interfere with each other.
Published Scientists develop novel radiotracer for earlier detection of disease
(via sciencedaily.com) Original source Scientists have developed a new radiotracer (called [18F]4-FDF) that can map how cells use fructose for energy.
Published Decline in microbial genetic richness in the western Arctic Ocean
(via sciencedaily.com) Original source Researchers analyzed archival samples of bacteria and archaea populations taken from the Beaufort Sea, bordering northwest Canada and Alaska. The samples were collected between 2004 and 2012, a period that included two years -- 2007 and 2012 -- in which the sea ice coverage was historically low. The researchers looked at samples taken from three levels of water: the summer mixed layer, the upper Arctic water below it and the Pacific-origin water at the deepest level. The study examined the microbes' genetic composition using bioinformatics and statistical analysis across the nine-year time span. Using this data, the researchers were able to see how changing environmental conditions were influencing the organisms' structure and function.
Published Genetic insights and conservation challenges of Nara's sacred deer
(via sciencedaily.com) Original source In Nara, Japan, the revered sika deer faces a dilemma as their escalating population damages local farmlands. A new study has revealed a complex situation: while the sanctuary's deer upholds a distinct genetic identity, the surrounding areas display a blend of genetic lineages. This exposes a pressing predicament: whether to cull the 'pest' deer around sanctuary or risk losing a sacred genetic legacy.
Published Eating too much protein is bad for your arteries, and this amino acid is to blame
(via sciencedaily.com) Original source Consuming over 22% of dietary calories from protein can lead to increased activation of immune cells that play a role in atherosclerotic plaque formation and drive the disease risk, new study showed.
Published Viruses that can help 'dial up' carbon capture in the sea
(via sciencedaily.com) Original source Armed with a catalog of hundreds of thousands of DNA and RNA virus species in the world's oceans, scientists are now zeroing in on the viruses most likely to combat climate change by helping trap carbon dioxide in seawater or, using similar techniques, different viruses that may prevent methane's escape from thawing Arctic soil.
Published Giant Antarctic sea spiders reproductive mystery solved
(via sciencedaily.com) Original source Instead of carrying the babies until they hatched, as in most species of sea spiders, one parent (likely the father) spent two days attaching the eggs to the rocky bottom where they developed for several months before hatching as tiny larvae.
Published Anoxic marine basins are among the best candidates for deep-sea carbon sequestration
(via sciencedaily.com) Original source Anoxic marine basins may be among the most viable places to conduct large-scale carbon sequestration in the deep ocean, while minimizing negative impacts to marine life. As we explore ways to actively draw down the levels of carbon in the atmosphere, sending plant biomass to these barren, oxygen-free zones on the seafloor becomes an option worth considering.
Published Beyond peak season: Bacteria in the Arctic seabed are active all year round
(via sciencedaily.com) Original source Researchers studied the composition and function of bacteria in the seabed off Svalbard, during alternating periods of polar night and midnight sun. To do this, they specially developed a sampling device, the Ellrott grab. In contrast with bacterial communities in the overlying water, the sediment bacteria hardly change with the seasons. This is probably due to the fact that in the seabed some hard-to-digest foods are available all year round.
Published Toxoplasmosis: Evolution of infection machinery
(via sciencedaily.com) Original source Researchers have identified a protein that evolved concurrently with the emergence of cellular compartments crucial for the multiplication of the toxoplasmosis pathogen.
Published Searching for clues in the history book of the ocean
(via sciencedaily.com) Original source New research has shown that the tropical subsurface ocean gained oxygen during the Paleocene-Eocene Thermal Maximum (commonly referred to as PETM). During this short-lived interval of time in Earth s history that occurred 56 million years ago the average temperatures rose by up to six degrees within a few thousand years.
Published Superbug killer: New synthetic molecule highly effective against drug-resistant bacteria
(via sciencedaily.com) Original source A new antibiotic overcomes antimicrobial resistance mechanisms that have rendered many modern drugs ineffective and are driving a global public health crisis.