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Categories: Biology: Biotechnology, Geoscience: Oceanography
Published Protein complex discovered to control DNA repair
(via sciencedaily.com) Original source The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team has now discovered a previously unrecognized control point for these processes. This could lead to a new approach for the development of cancer therapies aimed at inhibiting the repair of damaged cancer cells.
Published A new type of plant metalloreductase maintains root growth under low phosphorus
(via sciencedaily.com) Original source Phosphorus is essential for undisturbed plant growth and development. However, in many soils, phosphorus is only poorly available. One mechanism used by plants to increase phosphorus availability is the release of malate, an organic acid, which can form complexes with iron or aluminium in the soil, thereby liberating sorbed phosphate. However, this response can also result in iron overaccumulation, which can inhibit root growth.
Published Focus on biological processes does not capture the whole picture
(via sciencedaily.com) Original source The ocean plays a crucial role in the storage of carbon dioxide (CO2). The so-called marine biological carbon pump is an important research topic in this context. However a key component is often overlooked. Colleagues outline why it is insufficient to focus solely on biological processes when investigating the accumulation of CO2 in the ocean by the biological carbon pump.
Published PFAS flow equally between Arctic Ocean and Atlantic Ocean
(via sciencedaily.com) Original source The frigid Arctic Ocean is far removed from the places most people live, but even so, 'forever chemicals' reach this remote landscape. Now, research suggests that per- and polyfluoroalkyl substances (PFAS) won't stay there indefinitely. Instead, they are transported in a feedback loop, with the Arctic Ocean potentially exporting as many PFAS to the North Atlantic Ocean as it receives, circulating the compounds around the world.
Published Acidity of Antarctic waters could double by century's end, threatening biodiversity
(via sciencedaily.com) Original source Without drastically reducing global emissions, the Antarctic Ocean could become too acidic for hundreds of species living there, many already endangered by rising temperatures and sea ice loss.
Published Largest diversity study of 'magic mushrooms' investigates the evolution of psychoactive psilocybin production
(via sciencedaily.com) Original source The genomic analysis of 52 Psilocybe specimens includes 39 species that have never been sequenced. Psilocybe arose much earlier than previously thought -- about 65 million years ago -- and the authors found that psilocybin was first synthesized in mushrooms in the genus Psilocybe. Their analysis revealed two distinct gene orders within the gene cluster that produces psilocybin. The two gene patterns correspond to an ancient split in the genus, suggesting two independent acquisitions of psilocybin in its evolutionary history. The study is the first to reveal such a strong evolutionary pattern within the gene sequences underpinning the psychoactive proteins synthesis.
Published With only the pawprints, researchers study elusive bobcat
(via sciencedaily.com) Original source With DNA recovered from animal tracks, scientists revealed information about the ancestry and microbial community of bobcats without having to sample the animal directly.
Published Smart skin bacteria are able to secrete and produce molecules to treat acne
(via sciencedaily.com) Original source An experimental study has shown that a type of skin bacterium can efficiently be engineered to produce a protein to regulate sebum production. This application could treat acne without compromising the homeostasis of the entire skin microbiome.
Published Large-scale mapping of pig genes could pave the way for new human medicines
(via sciencedaily.com) Original source Researchers have carried out complex genetic analyses of hundreds of pigs and humans to identify differences and similarities. This new knowledge can be used to ensure healthier pigs for farmers and can help the pharmaceutical industry breed better laboratory pigs for testing new medicines.
Published Life span increases in mice when specific brain cells are activated
(via sciencedaily.com) Original source A new study identifies, in mice, a critical communication pathway connecting the brain and the body's fat tissue in a feedback loop that appears central to energy production throughout the body. The research suggests that the gradual deterioration of this feedback loop contributes to the increasing health problems that are typical of natural aging.
Published Researchers discover molecular 'barcode' used by bacteria to secrete toxins
(via sciencedaily.com) Original source Researchers have discovered a molecular 'barcode' system used by disease-causing bacteria to distinguish between beneficial and toxic molecules.
Published Researchers develop algorithm to determine how cellular 'neighborhoods' function in tissues
(via sciencedaily.com) Original source Researchers have developed a new AI-powered algorithm to help understand how different cells organize themselves into particular tissues and communicate with one another.
Published Important membrane transport mechanism in pathogenic bacteria
(via sciencedaily.com) Original source Some bacterial membrane transporters work almost like freight elevators to transport substances through the cell membrane into the interior of the cell. The transporter itself spans the bacterial membrane. Like a forklift, a soluble protein outside the bacterium transports the substance to the 'elevator' and unloads its cargo there. The freight elevator transports it to the inside of the cell, in other words to another floor.
Published Evolution is not as random as previously thought
(via sciencedaily.com) Original source A groundbreaking study has found that evolution is not as unpredictable as previously thought, which could allow scientists to explore which genes could be useful to tackle real-world issues such as antibiotic resistance, disease and climate change. The study challenges the long-standing belief about the unpredictability of evolution, and has found that the evolutionary trajectory of a genome may be influenced by its evolutionary history, rather than determined by numerous factors and historical accidents.
Published Arctic cold snap transforms into a blessing
(via sciencedaily.com) Original source Scientists investigate the influence of Arctic cold air on carbon dioxide uptake of the east sea.
Published Advancing the generation of in-vivo chimeric lungs in mice using rat-derived stem cells
(via sciencedaily.com) Original source Creating a functional lung using interspecies chimeric animals is an attractive albeit challenging option for lung transplantation, requiring more research on the viable conditions needed for organ generation. A new study uses reverse-blastocyst complementation and tetraploid-based organ complementation methods to first determine these conditions in lung-deficient mice and then to generate rat-derived lungs in these mice. It provides useful insights on the intrinsic species-specific barriers and factors associated with lung development in interspecies chimeric animals.
Published A new approach can address antibiotic resistance to Mycobacterium abscessus
(via sciencedaily.com) Original source Scientists have created analogs of the antibiotic spectinomycin that are significantly more effective against these highly resistant bacteria.
Published Scientists engineer plant microbiome to protect crops against disease
(via sciencedaily.com) Original source Scientists have engineered the microbiome of plants for the first time, boosting the prevalence of 'good' bacteria that protect the plant from disease. The findings could substantially reduce the need for environmentally destructive pesticides.
Published Treating tuberculosis when antibiotics no longer work
(via sciencedaily.com) Original source A research team has detected various substances that have a dual effect against tuberculosis: They make the bacteria causing the disease less pathogenic for human immune cells and boost the activity of conventional antibiotics.
Published Nematode proteins shed light on infertility
(via sciencedaily.com) Original source Biologists developed a method for illuminating the intricate interactions of the synaptonemal complex in the nematode C. elegans. The authors identified a trio of protein segments that guide chromosomal interactions, and pinpointed the location where they interact with each other. Their novel method uses a technique known as genetic suppressor screening, which can serve as a blueprint for research on large cellular assemblies that resist traditional structural analysis.