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Categories: Anthropology: General, Biology: Biotechnology

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Cultivation and growth of grapevines have strongly influenced European civilizations, but where the grapevine comes from and how it has spread across the globe has been highly disputed so far. In an extensive genome project, researchers have determined its origin and evolution from the wild vine to today's cultivar by analyzing thousands of vine genomes collected along the Silk Road from China to Western Europe.

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Muscle degeneration, the most prevalent cause of frailty in hereditary diseases and aging, could be caused by a deficiency in one key enzyme in a lipid biosynthesis pathway. Researchers now characterize how the enzyme PCYT2 affects muscle health in disease and aging in laboratory mouse models.

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The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell. It also allows the replacement of used cells from a limited number of 'stem' cells, which then proliferate and specialize. In cancer, however, cell proliferation is no longer controlled and becomes chaotic. Researchers have discovered that, in a healthy individual, certain blood immune cells, the monocytes, also have this ability to proliferate, with the aim to replace tissue macrophages, which are essential for the proper functioning of our body.

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A new discovery, reported in a global study that encompassed more than a decade of research, could lead to the breeding of corn crops that can withstand drought and low-nitrogen soil conditions and ultimately ease global food insecurity.

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Without plants, we'd have no air to breathe or food to eat, yet plant science lingers in the shadowy wings while other fields take center stage. With the goal of shining the spotlight on plants, a new study presents the field's top 100 most pressing questions for research to address the greatest challenges facing humanity.

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An international research team produced the first large-scale analysis of more than 400 newly sequenced and existing Omnitrophota genomes, uncovering new details about their biology and behavior.

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It has long been known that viral infections can be more severe in males than females, but the question as to why has remained a mystery -- until possibly now. Researchers have found that female mouse and human Natural Killer cells have an extra copy of an X chromosome-linked gene called UTX. UTX acts as an epigenetic regulator to boost NK cell anti-viral function, while repressing NK cell numbers.

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A cytokinin-mediated, proliferation-based mechanism is involved in the generation and maintenance of cell-type specific tissue boundaries during vascular development in Arabidopsis roots. Specifically, the HANABA-TARANU transcription factor forms a feed-forward loop to cytokinin signaling, which in turn regulates the position and frequency of cell proliferation of proto-vascular cells such that mechanical stress of the surrounding tissues guides growth in an apical-oriented manor, maintaining cell patterning throughout the tissue section.

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The human immunodeficiency virus HIV-1 is able to infect various tissues in humans. Once inside the cells, the virus integrates its genome into the cellular genome and establishes persistent infections. The role of the structure and organization of the host genome in HIV-1 infection is not well understood. Using a cell culture model based on brain immune microglia cells, an international research team has now defined the insertion patterns of HIV-1 in the genome of microglia cells.

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The coveted metal copper and a sheltered location turned the Cypriot village of Hala Sultan Tekke into one of the most important trade hubs of the Late Bronze Age. Recent excavations confirm the importance of the Bronze Age city in the first period of international trade in the Mediterranean.

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'Miniature shredders' are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study now shows. For example, cancer cells have a special variant that can supply them particularly effectively with building blocks for their energy metabolism.

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Geneticists have written new chapters in the reconstruction of pre-colonial Americas history after using DNA from the indigenous Ashaninka people from Amazonian Peru. They have discovered previously unexpected levels of genetic variation in this group and uncovered a strong hint that these people were involved in a South-to-North migration that led to the transition from an archaic to ceramic culture in the Caribbean islands.

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Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways. A new review highlights six mechanisms by which cells repair DNA damage. By attacking these mechanisms, future applied researchers will be able to trip up cancer's reproduction and growth.

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Breaking a longstanding impasse in our understanding of olfaction, scientists have created the first molecular-level, 3D picture of how an odor molecule activates a human odorant receptor, a crucial step in deciphering the sense of smell.

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A new study represents a first step towards generating highly detailed 3-dimensional maps of lung tumors using genetically engineered mouse models.

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In a step forward for genetic engineering and synthetic biology, researchers have modified a strain of Escherichia coli bacteria to be immune to natural viral infections while also minimizing the potential for the bacteria or their modified genes to escape into the wild.

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Despite recent advancements, many highly sensitive diagnostic tests for viral diseases still require complicated techniques to prepare a sample or interpret a result, making them impractical for point-of-care settings or areas with few resources. But now, a team has developed a sensitive method that analyzes viral nucleic acids in as little as 20 minutes and can be completed in one step with 'glow-in-the-dark' proteins.

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A new study explores exactly what leads to the generation of Th17 cells -- an important subtype of cells in the intestine -- and uncovers some of the underappreciated molecular players and events that lead to cell differentiation in the gut.

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Extremely long tail provides structural window into how bacteria-infecting viruses called phages assemble.

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The agriculture industry is under pressure to adopt sustainable and precise agricultural practices that enable more efficient use of resources due to worsening environmental conditions resulting from climate change, an ever-expanding human population, limited resources, and a shortage of arable land. As a result, developing delivery systems that efficiently distribute micronutrients, pesticides, and antibiotics in crops is crucial to ensuring high productivity and high-quality produce while minimising resource waste. However, current and standard practices for agrochemical application in plants are inefficient. These practices cause significant detrimental environmental side effects, such as water and soil contamination, biodiversity loss and degraded ecosystems; and public health concerns, such as respiratory problems, chemical exposure and food contamination.