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Categories: Anthropology: General, Biology: Biotechnology

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Researchers have developed and demonstrated a new method for high-throughput single-cell sorting that uses stimulated Raman spectroscopy rather than the traditional approach of fluorescence-activated cell sorting. The new approach could offer a label-free, nondestructive way to sort cells for a variety of applications, including microbiology, cancer detection and cell therapy.

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The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.

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Researchers see potential in educational settings for the newest official ChatGPT plugin, called Code Interpreter, they've found limitations for its use by scientists who work with biological data utilizing computational methods to prioritize targeted treatment for cancer and genetic disorders.

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A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression.

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Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.

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Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.

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Researchers have dated drawings of Gua Sireh Cave in Sarawak, uncovering a sad story of conflict in the process.

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In a groundbreaking endeavor, researchers have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan. The research opens exciting possibilities for unlocking the secrets of aging and extending human lifespan.

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A discovery about how a common insect acquires a microbe that is essential for its growth may help in the control of an agricultural pest.

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The near extinction of the North American bison in the late 1800s caused a devastating, lasting economic shock to Indigenous peoples whose lives depended on the animals, an economic study finds.

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Regulatory genes -- genes that control how other genes are used -- are responsible for 69% of the heritability of dairy cattle traits such as milk production and fertility, according to a new study. This contribution is 44% more than expected and much higher than previous studies of regulatory genes in humans. The findings, reported by a team of animal and human geneticists, could improve the efficiency of agricultural breeding programs. The study also helps solve the longstanding mystery of why mammalian genomes contain so much noncoding DNA.

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Researchers have analyzed the genomes of skeletons from an extended family from a Bronze Age necropolis in the Russian steppe. The 3,800-year-old 'Nepluyevsky' burial mound was excavated several years ago and is located on the geographical border between Europe and Asia. Using statistical genomics, the family and marriage relationships of this society have now been deciphered.

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Archaeologists have long been drawing conclusions about how ancient tools were used by the people who crafted them based on written records and context clues. But with dietary practices, they have had to make assumptions about what was eaten and how it was prepared. A new study analyzed protein residues from ancient cooking cauldrons and found that the people of Caucasus ate deer, sheep, goats, and members of the cow family during the Maykop period (3700--2900 BCE).

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Cranial modification is a form of body alteration where the head is pressed or bound to permanently deform the skull. The practice has been reported across various cultures throughout history. Researchers report that the Hirota people -- who lived on the southern Japanese island of Tanegashima between the 3rd to 7th century CE -- also conducted cranial modification, with indication that both males and females performed the practice.

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A research team has used advanced sequencing technology to analyze Ötzi's genome to obtain a more accurate picture of the Iceman's appearance and genetic origins.

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Recent paleogenomic research revealed that interbreeding was common among early human species. However, little was known about when, where, and how often this hominin interbreeding took place. Using paleoanthropological evidence, genetic data, and supercomputer simulations of past climate, a team of international researchers has found that interglacial climates and corresponding shifts in vegetation created common habitats for Neanderthals and Denisovans, increasing their chances for interbreeding and gene flow in parts of Europe and central Asia.

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A system of ancient ceramic water pipes, the oldest ever unearthed in China, shows that neolithic people were capable of complex engineering feats without the need for a centralized state authority, finds a new study.

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A new study finds that past changes in atmospheric CO2 and corresponding shifts in climate and vegetation played a key role in determining when and where early human species interbred.

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A new study finds that around 1.12 million years ago a massive cooling event in the North Atlantic and corresponding shifts in climate, vegetation and food resources disrupted early human occupation of Europe.

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Using ancient DNA, researchers have determined cattle were imported from Africa to the Americas much earlier in the process of European colonization than documented. The first records of African cattle in the Americas date back to the 1800s, leading some historians to conclude that early colonists relied entirely on a small stock of European cattle initially shipped to the Caribbean Islands. DNA from archaeological specimens pushes the introduction of African cattle back by more than 100 years.