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Categories: Archaeology: General, Biology: Biotechnology

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A detailed survey of the volcanic underwater deposits around the Kikai caldera in Japan clarified the deposition mechanisms as well as the event's magnitude. As a result, the research team found that the event 7,300 years ago was the largest volcanic eruption in the Holocene by far.

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A professor has demonstrated a connection between viral damage to the gut and premature biological aging.

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The sea lamprey, a 500-million-year-old animal with a sharp-toothed suction cup for a mouth, is the thing of nightmares. A new study discovered that the hindbrain -- the part of the brain controlling vital functions like blood pressure and heart rate -- of both sea lampreys and humans is built using an extraordinarily similar molecular and genetic toolkit.

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With ever-increasing life expectancy comes the challenge of treating age-related disorders such as osteoporosis. Although there are effective drugs for treating this metabolic bone disease, they can be expensive and have side effects, limiting their availability to some people. In the search for alternative drug candidates, researchers have discovered and fully replicated a compound from a botanical source, female ginseng, that had potent anti-osteoporotic activity in cellular tests.

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Established treatments for cancer and other diseases often focus on inhibiting harmful enzymes to mitigate their effects. However, a more innovative approach has emerged: harnessing the cell's natural waste disposal system not just to deactivate but to entirely eradicate these proteins. Researchers have previously demonstrated the efficacy of this approach through two distinct methods. Now they unveil a third system capable of targeting and disposing of previously inaccessible proteins.

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A new analysis method can detect pathogens in blood samples faster and more accurately than blood cultures, which are the current state of the art for infection diagnosis. The new method, called digital DNA melting analysis, can produce results in under six hours, whereas culture typically requires 15 hours to several days, depending on the pathogen.

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Researchers found that PD-1-enhanced DNA vaccination can induce sustained virus-specific CD8+ T cell immunity in an AIDS monkey model. The vaccinated monkeys remained free of AIDS for six years and achieved virologic control without the need for combination antiretroviral therapy (cART), a treatment used to suppress viral replication in individuals living with human immunodeficiency virus (HIV). The study also found that polyfunctional and broadly reactive effector-memory virus-specific T cells were maintained in the protected experimental macaques for over six years. The findings provide supporting evidence that the PD-1-enhanced DNA vaccine strategy holds promise as a third-generation DNA vaccine for AIDS prevention and immunotherapy.

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A pharmacy associate professor has developed a novel nanomedicine loaded with genetic material called small interfering RNAs (siRNA) to fight human immunodeficiency virus (HIV) using gene therapy.

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Researchers have developed a multipronged strategy to identify the transporters used by different drugs. Their approach, which makes use of both tissue models and machine-learning algorithms, has already revealed that a commonly prescribed antibiotic and a blood-thinner can interfere with each other.

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Scientists have developed a new radiotracer (called [18F]4-FDF) that can map how cells use fructose for energy.

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By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

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In Nara, Japan, the revered sika deer faces a dilemma as their escalating population damages local farmlands. A new study has revealed a complex situation: while the sanctuary's deer upholds a distinct genetic identity, the surrounding areas display a blend of genetic lineages. This exposes a pressing predicament: whether to cull the 'pest' deer around sanctuary or risk losing a sacred genetic legacy.

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Consuming over 22% of dietary calories from protein can lead to increased activation of immune cells that play a role in atherosclerotic plaque formation and drive the disease risk, new study showed.

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Researchers have identified a protein that evolved concurrently with the emergence of cellular compartments crucial for the multiplication of the toxoplasmosis pathogen.

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A new antibiotic overcomes antimicrobial resistance mechanisms that have rendered many modern drugs ineffective and are driving a global public health crisis.

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A new study reveals that the first farmers and herdsmen settled in Andalusia collected and consumed shellfish throughout the year, especially in winter.

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When the female gametes in plants become fertilized, a signal from the sperm activates cell division, leading to the formation of new plant seeds. This activation can also be deliberately triggered without fertilization, as researchers have shown. Their findings open up new avenues for the asexual propagation of crop plants.

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Researchers report that ancient viruses may be to thank for myelin -- and, by extension, our large, complex brains. The team found that a retrovirus-derived genetic element or 'retrotransposon' is essential for myelin production in mammals, amphibians, and fish. The gene sequence, which they dubbed 'RetroMyelin,' is likely a result of ancient viral infection, and comparisons of RetroMyelin in mammals, amphibians, and fish suggest that retroviral infection and genome-invasion events occurred separately in each of these groups.

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Located at the Callacpuma archaeological site in the Cajamarca Basin of northern Peru, the plaza is built with large, vertically placed megalithic stones -- a construction method previously unseen in the Andes.

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A research team has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer's disease brain neurons.