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Categories: Archaeology: General, Biology: Biotechnology

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The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team has now discovered a previously unrecognized control point for these processes. This could lead to a new approach for the development of cancer therapies aimed at inhibiting the repair of damaged cancer cells.

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A new study shows how state-of-the-art methods and perspectives from archaeology, history, and palaeoecology are shedding new light on 5,500 years of urban life.

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Researchers have developed a new technique to measure the number of chromosomes in ancient genomes more precisely, using it to identify the first prehistoric person with mosaic Turner syndrome (characterized by one X chromosome instead of two [XX]), who lived about 2500 years ago.

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Phosphorus is essential for undisturbed plant growth and development. However, in many soils, phosphorus is only poorly available. One mechanism used by plants to increase phosphorus availability is the release of malate, an organic acid, which can form complexes with iron or aluminium in the soil, thereby liberating sorbed phosphate. However, this response can also result in iron overaccumulation, which can inhibit root growth.

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The North Arabian Desert oases were inhabited by sedentary populations in the 4th and 3rd millennia BCE. A fortification enclosing the Khaybar Oasis -- one of the longest known going back to this period -- was just revealed by a team of scientists. This new walled oasis is, along with that of Tayma, one of the two largest in Saudi Arabia.

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The largest ever primate Gigantopithecus blacki went extinct when other Asian great apes were thriving, and its demise has long been a mystery. A massive regional study of 22 caves in southern China explores a species on the brink of extinction between 295,000 and 215,000 years ago. As the environment became more seasonal, forest plant communities changed Primates such as orangutans adapted their eating habits and behaviors in response but G. blacki showed signs of stress, struggled to adapt and their numbers dwindled.

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The genomic analysis of 52 Psilocybe specimens includes 39 species that have never been sequenced. Psilocybe arose much earlier than previously thought -- about 65 million years ago -- and the authors found that psilocybin was first synthesized in mushrooms in the genus Psilocybe. Their analysis revealed two distinct gene orders within the gene cluster that produces psilocybin. The two gene patterns correspond to an ancient split in the genus, suggesting two independent acquisitions of psilocybin in its evolutionary history. The study is the first to reveal such a strong evolutionary pattern within the gene sequences underpinning the psychoactive proteins synthesis.

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With DNA recovered from animal tracks, scientists revealed information about the ancestry and microbial community of bobcats without having to sample the animal directly.

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An experimental study has shown that a type of skin bacterium can efficiently be engineered to produce a protein to regulate sebum production. This application could treat acne without compromising the homeostasis of the entire skin microbiome.

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Researchers have carried out complex genetic analyses of hundreds of pigs and humans to identify differences and similarities. This new knowledge can be used to ensure healthier pigs for farmers and can help the pharmaceutical industry breed better laboratory pigs for testing new medicines.

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A new study describes nine new species of carnivorous land snails, all of which are so small they could fit together on a U.S. nickel. They present a rare opportunity to study a group that in many other places is disappearing fast. Worldwide, mollusks account for more than 50% of all recorded extinctions since the year 1500, and many of these were land snails from Pacific islands.

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A new study identifies, in mice, a critical communication pathway connecting the brain and the body's fat tissue in a feedback loop that appears central to energy production throughout the body. The research suggests that the gradual deterioration of this feedback loop contributes to the increasing health problems that are typical of natural aging.

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Researchers have discovered a molecular 'barcode' system used by disease-causing bacteria to distinguish between beneficial and toxic molecules.

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Researchers have developed a new AI-powered algorithm to help understand how different cells organize themselves into particular tissues and communicate with one another.

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Some bacterial membrane transporters work almost like freight elevators to transport substances through the cell membrane into the interior of the cell. The transporter itself spans the bacterial membrane. Like a forklift, a soluble protein outside the bacterium transports the substance to the 'elevator' and unloads its cargo there. The freight elevator transports it to the inside of the cell, in other words to another floor.

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A groundbreaking study has found that evolution is not as unpredictable as previously thought, which could allow scientists to explore which genes could be useful to tackle real-world issues such as antibiotic resistance, disease and climate change. The study challenges the long-standing belief about the unpredictability of evolution, and has found that the evolutionary trajectory of a genome may be influenced by its evolutionary history, rather than determined by numerous factors and historical accidents.

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Researchers have discovered an ancient Roman temple that adds significant insights into the social change from pagan gods to Christianity within the Roman Empire.

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Creating a functional lung using interspecies chimeric animals is an attractive albeit challenging option for lung transplantation, requiring more research on the viable conditions needed for organ generation. A new study uses reverse-blastocyst complementation and tetraploid-based organ complementation methods to first determine these conditions in lung-deficient mice and then to generate rat-derived lungs in these mice. It provides useful insights on the intrinsic species-specific barriers and factors associated with lung development in interspecies chimeric animals.

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Scientists have created analogs of the antibiotic spectinomycin that are significantly more effective against these highly resistant bacteria.

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Scientists have engineered the microbiome of plants for the first time, boosting the prevalence of 'good' bacteria that protect the plant from disease. The findings could substantially reduce the need for environmentally destructive pesticides.