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Categories: Biology: Biotechnology, Paleontology: General

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A new drug candidate targeting E. coli in the gut is in phase 1 clinical trials. According to a new paper it may improve the well-being of blood cancer patients and reduce their mortality rate from E. coli infections.

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Researchers describe developing a super-resolution imaging platform technology to improve understanding of how nanoparticles interact within cells.

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Researchers have developed a DNA enzyme -- or DNAzyme -- that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough 'gene silencing' technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.

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Scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers.

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New research shows the use of a new cellular probe helped discover new findings about certain cellular processes.

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Using a new technique, researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.

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Scientists find new route in bacteria to decarbonize industry. The discovery could reduce greenhouse gas emissions from the manufacturing of fuels, drugs, and chemicals. A research team has engineered bacteria to produce new-to-nature carbon products that could provide a powerful route to sustainable biochemicals.

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Researchers have made a major breakthrough earlier this year in the field of evolutionary conservation of molecular dynamics in enzymes. Their work points to potential applications in health, including the development of new drugs to treat serious diseases such as cancer or to counter antibiotic resistance.

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Microbiologists have uncovered the evolutionary origins of antimicrobial resistance (AMR) in bacteria. His studies on the bacterium that causes cholera, Vibrio cholerae, provide insight into deciphering what conditions must occur for infectious agents to become resistant. He studied genetic variants of a protein found in bacterial membranes called OmpU. Using computational and molecular approaches, his team found that several OmpU mutations in the cholera bacteria led to resistance to numerous antimicrobial agents. This resistance included antimicrobial peptides that act as defenses in the human gut.

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Phytosterols are good for your health, but humans and other animals are not able to make them themselves, only plants can. To acquire phytosterols, humans are increasingly turning to supplements, green smoothies, or a Mediterranean diet with plenty of plant-based foods. Researchers have now discovered that tiny gutless worms from the Mediterranean can synthesize phytosterols on their own. Their study provides evidence that many other animals also have the genes needed to make their own phytosterols.

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Researchers discover a unique two-component molecular motor that uses a kind of renewable chemical energy to pull vesicles toward membrane-bound organelles.

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An international research team has for the first time successfully isolated ancient human DNA from a Paleolithic artefact: a pierced deer tooth discovered in Denisova Cave in southern Siberia. To preserve the integrity of the artefact, they developed a new, nondestructive method for isolating DNA from ancient bones and teeth. From the DNA retrieved they were able to reconstruct a precise genetic profile of the woman who used or wore the pendant, as well as of the deer from which the tooth was taken. Genetic dates obtained for the DNA from both the woman and the deer show that the pendant was made between 19,000 and 25,000 years ago. The tooth remains fully intact after analysis, providing testimony to a new era in ancient DNA research, in which it may become possible to directly identify the users of ornaments and tools produced in the deep past.

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Traces of sex hormones extracted from a woolly mammoth's tusk provide the first direct evidence that adult males experienced musth, a testosterone-driven episode of heightened aggression against rival males, according to a new study.

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A team of researchers develops stem cell adhesive for arthritis treatment using mussel adhesion protein and hyaluronic acid.

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Gene-editing therapy aimed at two targets -- HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells -- can effectively eliminate HIV infection, new research shows. The study combines a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1.

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A recent study found that many of the fossils from Germany's Posidonia shale do not get their gleam from pyrite, commonly known as fool's gold, which was long thought to be the source of the shine. Instead, the golden hue is from a mix of minerals that hints at the conditions in which the fossils formed. The discovery is important for understanding how the fossils -- which are among the world's best-preserved specimens of sea life from the Early Jurassic -- came to form in the first place, and the role that oxygen in the environment had in their formation.

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Researchers have proposed a new evolutionary model for the origin of a kingdom of viruses called Bamfordvirae, suggesting a billion-years evolutionary arms race between two groups within this kingdom and their hosts.

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According to researchers, a new analysis of an 80-million-year-old permineralized pollen cone found in the Campanian Holz Shale formation located in Silverado Canyon, California, offers a more accurate cycad natural history -- one where the plants diversified during the Cretaceous.

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Dynamic network in the pores of the nuclear envelope blocks dangerous invaders.

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A new study on herpes infections of the eye helps shed light on the question of viral reinfections by identifying a key protein involved in viral reinfections that could be targeted by antiviral drugs.