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Categories: Biology: Biotechnology, Paleontology: General
Published Scientists unveil genetics behind development of gliding
(via sciencedaily.com) Original source Researchers explain the genomic and developmental basis of the patagium, the thin skin membrane that allows some mammalian species to soar through the air.
Published Researchers create artificial cells that act like living cells
(via sciencedaily.com) Original source Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.
Published Fossil frogs share their skincare secrets
(via sciencedaily.com) Original source Palaeontologists have solved a hundred-year-old mystery of how some fossil frogs preserve their fleshy parts -- it's all down to their skin. Palaeontologists studied 45-million-year-old fossil frogs from the Geiseltal site in central Germany. Remarkably, the fossils show full body outlines of the soft tissues. The team discovered that the excellent condition of the fossil frogs is due to preservation of ancient skin remnants.
Published AI tool creates 'synthetic' images of cells for enhanced microscopy analysis
(via sciencedaily.com) Original source Researchers have developed a method to use an image generation AI model to create realistic images of single cells, which are then used as 'synthetic data' to train an AI model to better carry out single-cell segmentation.
Published Liquid droplets shape how cells respond to change
(via sciencedaily.com) Original source New research has shown that cells regulate cAMP/PKA signaling by forming liquid droplets that segregate excess PKA catalytic subunits where they can do no harm. Some cancers may block the formation of liquid droplets, leading to hyperactive signaling and tumor formation.
Published AI can improve Alzheimer's treatment through the 'gut-brain axis'
(via sciencedaily.com) Original source Researchers are using artificial intelligence to uncover the link between the gut microbiome and Alzheimer's disease. Previous studies showed that Alzheimer's disease patients have changes in their gut bacteria as the disease develops. The study outlines a computational method to determine how bacterial byproducts called metabolites interact with receptors on cells and contribute to Alzheimer's disease.
Published Scientists discover the cellular functions of a family of proteins integral to inflammatory diseases
(via sciencedaily.com) Original source In a scientific breakthrough, researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.
Published Switching off the light to see better
(via sciencedaily.com) Original source Researchers used structured light and switchable fluorescent molecules to reduce the background light from the out-of-plane regions of microscope samples. This method allowed for the acquisition of images that surpassed the conventional resolution limit, and it may be useful for further study of cell clusters and other biological systems.
Published Protein network dynamics during cell division
(via sciencedaily.com) Original source An international team has mapped the movement of proteins encoded by the yeast genome throughout its cell cycle. This is the first time that all the proteins of an organism have been tracked across the cell cycle, which required a combination of deep learning and high-throughput microscopy.
Published Breakthrough rice bran nanoparticles show promise as affordable and targeted anticancer agent
(via sciencedaily.com) Original source Plant-derived nanoparticles have demonstrated significant anticancer effects. Researchers recently developed rice bran-derived nanoparticles (rbNPs) that efficiently suppressed cell proliferation and induced programmed cell death of only cancer cells. Furthermore, rbNPs successfully suppressed the growth of tumors in mice having aggressive adenocarcinoma in their peritoneal cavity, without any adverse effects. Given their low production costs and high efficacy, rbNPs hold great promise for developing affordable and safe anticancer agents.
Published New compound from blessed thistle promotes functional nerve regeneration
(via sciencedaily.com) Original source Blessed thistle (Cnicus benedictus) is a plant in the family Asteraceae. For centuries, it has been used as a medicinal herb as an extract or tea, e.g. to aid the digestive system. Researchers have now found a completely novel use for Cnicin. Animal models as well as human cells have shown that Cnicin significantly accelerates axon (nerve fibers) growth.
Published Key protein regulates immune response to viruses in mammal cells
(via sciencedaily.com) Original source Researchers have revealed the regulatory mechanism of a specific protein, TRBP, that plays a key role in balancing the immune response triggered by viral infections in mammal cells. These findings could help drive the development of antiviral therapies and nucleic acid medicines to treat genetic disorders.
Published Light show in living cells
(via sciencedaily.com) Original source Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge -- especially in living cells, as the required fluorescent labeling had to be individually attached to each protein. The research group has now overcome this hurdle: With a method called 'vpCells,' it is possible to label many proteins simultaneously, using five different fluorescent colors.
Published Marine microbial populations: Potential sensors of the global change in the ocean
(via sciencedaily.com) Original source Animal and plant populations have been extensively studied, which has helped to understand ecosystem processes and evolutionary adaptations. However, this has not been the case with microbial populations due to the impossibility of isolating, culturing and analyzing the genetic content of the different species and their individuals in the laboratory. Therefore, although it is known that populations of microorganisms include a great diversity, this remains largely uncharacterized.
Published RNA's hidden potential: New study unveils its role in early life and future bioengineering
(via sciencedaily.com) Original source The origin of life continues to remain a matter of debate. The ribonucleic acid (RNA) world hypothesis proposes that 'ribozymes' which store genetic information and possess catalytic functions may have supported the activities of early life forms. Now, researchers explore how RNA elongation is regulated allosterically, shedding light on its impact on early life processes and offering insights into the fabrication of arbitrary RNA nanostructures with various modern applications.
Published Calorie restriction study reveals complexities in how diet impacts aging
(via sciencedaily.com) Original source The rate at which human cells age is influenced by multiple interconnected factors. New research examined how restricting calories influences telomere length and biological aging.
Published Ice age climate analysis reduces worst-case warming expected from rising CO2
(via sciencedaily.com) Original source A detailed reconstruction of climate during the most recent ice age, when a large swath of North America was covered in ice, provides information on the relationship between CO2 and global temperature. Results show that while most future warming estimates remain unchanged, the absolute worst-case scenario is unlikely.
Published Paleontologists unearth what may be the largest known marine reptile
(via sciencedaily.com) Original source The fossilized remains of a second gigantic jawbone measuring more than two meters long has been found on a beach in Somerset, UK.
Published Marine plankton behavior could predict future marine extinctions
(via sciencedaily.com) Original source Marine communities migrated to Antarctica during the Earth's warmest period in 66 million years long before a mass-extinction event.
Published Genetic variant identified that shaped the human skull base
(via sciencedaily.com) Original source Researchers have identified a variant in the gene TBX1 as key in the development of the unique morphology at the base of the skull. TBX1 is present at higher levels in humans than in closely related hominins. Low TBX1 also occurs in certain genetic conditions causing altered skull base morphology. This study provides a greater understanding of human disease and evolution.