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Categories: Biology: Biotechnology, Paleontology: General
Published Taking a 'one in a million' shot to tackle dopamine-linked brain disorders
(via sciencedaily.com) Original source With the help of a tiny, transparent worm called Caenorhabditis elegans, researchers have identified novel players in dopamine signaling by taking advantage of a powerful platform generated via the Million Mutation Project (MMP) for the rapid identification of mutant genes based on their functional impact. They can seek insights from simpler organisms whose genes bear striking similarity to those found in humans and where opportunities for genetic insights to disease can be pursued more efficiently and inexpensively.
Published An appetizer can stimulate immune cells' appetite, a boon for cancer treatments
(via sciencedaily.com) Original source The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer. Chief among this force is the macrophage, a white blood cell that surveils tissues and consumes pathogens, debris, dead cells, and cancer. Macrophages have a delicate task. It's crucial that they ignore healthy cells while on patrol, otherwise they could trigger an autoimmune response while performing their duties.
Published New genetically engineered wood can store carbon and reduce emissions
(via sciencedaily.com) Original source Researchers genetically modified poplar trees to produce high-performance, structural wood without the use of chemicals or energy intensive processing.
Published A new mechanism for shaping animal tissues
(via sciencedaily.com) Original source A key question that remains in biology and biophysics is how three-dimensional tissue shapes emerge during animal development. Research teams have now found a mechanism by which tissues can be 'programmed' to transition from a flat state to a three-dimensional shape.
Published New two-step flu vaccine strategy shows promise in pig model
(via sciencedaily.com) Original source A new, two-step flu vaccination strategy that pairs intramuscular injection of a viral vectored flu vaccine with nasal spray administration of a novel attenuated live flu virus appears to be safe and effective in pigs, researchers report.
Published Millions of years for plants to recover from global warming
(via sciencedaily.com) Original source Catastrophic volcanic eruptions that warmed the planet millions of years ago shed new light on how plants evolve and regulate climate. Researchers reveal the long-term effects of disturbed natural ecosystems on climate in geological history and its implications for today.
Published Largest protein yet discovered builds algal toxins
(via sciencedaily.com) Original source While seeking to unravel how marine algae create their chemically complex toxins, scientists have discovered the largest protein yet identified in biology. Uncovering the biological machinery the algae evolved to make its intricate toxin also revealed previously unknown strategies for assembling chemicals, which could unlock the development of new medicines and materials.
Published Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy
(via sciencedaily.com) Original source Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient. Now, researchers have developed a machine-learning approach that promises to speed up AAV engineering for gene therapy. The tool helps researchers engineer the protein shells of AAVs, called capsids, to have multiple desirable traits, such as the ability to deliver cargo to a specific organ but not others or to work in multiple species. Other methods only look for capsids that have one trait at a time.
Published Bacteria encode hidden genes outside their genome--do we?
(via sciencedaily.com) Original source A 'loopy' discovery in bacteria is raising fundamental questions about the makeup of our own genome -- and revealing a potential wellspring of material for new genetic therapies.
Published Researchers develop AI model that predicts the accuracy of protein--DNA binding
(via sciencedaily.com) Original source A new artificial intelligence model can predict how different proteins may bind to DNA.
Published Researchers make breakthrough in understanding species abundance
(via sciencedaily.com) Original source The key finding was that temperature and genome size, not body size, had the greatest influence on the maximum population growth rate of the diatoms. Yet body size still mattered in colder latitudes, conserving Bermann's Rule.
Published Researchers crack a key celiac mystery
(via sciencedaily.com) Original source An interdisciplinary team of medical and engineering researchers has spent the last six years working to unlock a significant piece of the puzzle in the search for a cure: how and where the gluten response begins.
Published 3D bioprinting advances research on respiratory viruses
(via sciencedaily.com) Original source Researchers develop a microstructured 'artificial lung' model using bioprinting technology.
Published Early mammals lived longer
(via sciencedaily.com) Original source What distinguishes the growth and development patterns of early mammals of the Jurassic period? Paleontologists have been able to gauge the lifespan and growth rates of these ancient animals, and even when they reached maturity, by studying growth rings in fossilized tooth roots.
Published Microscopy technique 'paves way' for improving understanding of cellular functions
(via sciencedaily.com) Original source Scientists have developed a new way of counting labelled proteins in living cells that could become a standard and valuable tool in the field of biomedical research.
Published Mix of factors prompts owl monkeys to leave their parents
(via sciencedaily.com) Original source There comes a point in the lives of young owl monkeys when they leave their parents and strike out on their own to find a mate. In a new study of a wild population of Azara's owl monkeys in northern Argentina, researchers reveal that a combination of social and ecological factors influences when these tree-dwelling monkeys peel away from their parents and siblings. According to their findings -- which were based on 25 years of genetic and demographic data for several generations of owl monkeys, covering more than 330 individuals -- none of the individuals, regardless of their sex, reproduced in the same group where they were born. In all cases, the researchers found, the animals either departed from their natal group or died before reproducing.
Published How ribosomes in our cells enable protein folding
(via sciencedaily.com) Original source Scientists discovered a role played by ribosomes during the folding of new proteins in cells.
Published Viral defense protein speeds up female stem cell production
(via sciencedaily.com) Original source A viral defense mechanism can be used to accelerate the creation of female stem cell lines in mice. The findings can boost efforts in medical research, drug testing, and regenerative therapies, particularly for women and individuals with two X chromosomes.
Published When mammoths roamed Vancouver Island
(via sciencedaily.com) Original source Mammoths, the massive pre-historic ice age cousins of the modern-day elephant, have always been understood to have inhabited parts of British Columbia, but the question of when has always been a bit woolly. Now, a new study has given scientists the clearest picture yet when the giant mammals roamed Vancouver Island.
Published Discovering how plants make life-and-death decisions
(via sciencedaily.com) Original source Researchers have discovered two proteins that work in tandem to control an important response to cell stress.