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Categories: Biology: Biotechnology, Paleontology: Fossils

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A team of researchers has found a mechanism in thale cress (Arabidopsis thaliana) which enables plants to provide protection against salt stress for their sensitive stem cells in the meristem at the root tip.

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Excess sugar hampers cells that renew the colon's lining in a mouse model of inflammatory bowel disease (IBD), according to a new study that could help get to the bottom of why limiting sugary foods can ease symptoms for patients with IBD.

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Researchers were able to identify changes in the accessibility (that is, the 'readability') of transposable elements. To do this, the researchers used an approach combining various sets of multiomics data, which characterize and quantify collections of biomolecules in cells or organisms. One was the transcriptome, which consists of all copies of RNA transcribed from DNA in the cell. The other was the epigenome, which is the collection of chemical changes to DNA that modify gene expression. An advantage of this multiomics approach is that they were able to identify families of transposable elements with changes in accessibility, which would have likely been missed by previous approaches.

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Scientists have developed a groundbreaking new technique for engineering biosensors that respond sensitively to specific biomolecules, enhancing cell migration and targeting in cancer treatment. The findings could lead to more precise control over cellular processes for a wide range of therapeutic applications.

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Every day, millions of cells die in our body. Other than generally assumed, cells do not simply burst at the end of their lives but rather, a specific protein serves as a breaking point for cell membrane rupture. Researchers have now been able to elucidate the exact mechanism at the atomic level.

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Plants show enormous variety in traits relevant to breeding, such as plant height, yield and resistance to pests. One of the greatest challenges in modern plant research is to identify the differences in genetic information that are responsible for this variation.

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Along with sugar reallocation, a basic molecular mechanism within plants controls the formation of new lateral roots. Botanists have demonstrated that it is based on the activity of a certain factor, the target of rapamycin (TOR) protein. A better understanding of the processes that regulate root branching at the molecular level could contribute to improving plant growth and therefore crop yields, according to the research team leader.

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A tiger-sized saber-toothed creature called Inostrancevia has previously only been found in Russia. But scientists have discovered its fossils in South Africa, suggesting that it migrated 7,000 miles across the supercontinent Pangaea during the world's worst mass extinction 252 million years ago. Heading to South Africa allowed it to fill a gap in a faraway ecosystem that had lost its top predators.

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Biophysicists have designed a new cell-like transport system that represents an important milestone on the road to artificial cells.

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New evidence for the presence of ancient lakes in some of the most arid regions of South Africa suggests that Stone Age humans may have been more widespread across the continent than previously thought.

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Written sources from Mesopotamia suggest that kissing in relation to sex was practiced by the peoples of the ancient Middle East 4,500 years ago.

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Researchers have discovered a new nutrient source that pancreatic cancer cells use to grow. The molecule, uridine, offers insight into both biochemical processes and possible therapeutic pathways. The findings show that cancer cells can adapt when they don't have access to glucose.

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Scales, spines, feathers and hair are examples of vertebrate skin appendages, which constitute a remarkably diverse group of micro-organs. Despite their natural multitude of forms, these appendages share early developmental processes at the embryonic stage. Researchers have discovered how to permanently transform the scales that normally cover the feet of chickens into feathers, by specifically modifying the expression of certain genes.

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Pain is good. It's the body's way to keep an animal from harming itself or repeating a dangerous mistake. But sometimes the debilitating sensation can get in the way. So evolution has devised ways to tamp that response down under certain circumstances.

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In testing the genetic material of current populations in Africa and comparing against existing fossil evidence of early Homo sapiens populations there, researchers have uncovered a new model of human evolution -- overturning previous beliefs that a single African population gave rise to all humans.

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A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.

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The deadly hospital pathogen Acinetobacter baumannii can live for a year on a hospital wall without food and water. Then, when it infects a vulnerable patient, it resists antibiotics as well as the body's built-in infection-fighting response. The World Health Organization (WHO) recognizes it as one of the three top pathogens in critical need of new antibiotic therapies. Now, an international team, led by Macquarie University researchers Dr. Ram Maharjan and Associate Professor Amy Cain, have discovered how the superbug can survive harsh environments and then rebound, causing deadly infections. They have found a single protein that acts as a master regulator. When the protein is damaged, the bug loses its superpowers allowing it to be controlled, in a lab setting. The research is published this month in Nucleic Acids Research.

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Researchers have mapped out what a commonly-used form of phage looks like, which will help design better uses in future.

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Scientists have precisely identified base pairs of the human genome that remained consistent over millions of years of mammalian evolution, and which play a crucial role in human disease. The team analyzed the genomes of 240 mammals, including humans and identified base pairs that were 'constrained' -- meaning they remained generally consistent -- across mammal species over the course of evolution. The most constrained base pairs in mammals were over seven times more likely to be causal for human disease and complex trait, and over 11 times more likely when researchers looked at the most constrained base pairs in primates alone.

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Researchers have examined a specific type of stem cell with an intracellular toolkit to determine which cells are most likely to create effective cell therapies.