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Categories: Biology: Biotechnology, Paleontology: Fossils

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Researchers have discovered a strong immunological effect of the molecule LecB -- and a way to prevent it.

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A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The research describes how 'epigenetic' changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the 'dark matter' of the genome.

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A detailed atlas of gene expression in the zebrafish brain.

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Scientists thought a gold-throated hummingbird was a new species. DNA revealed that it's a hybrid of two different species, each with pink throats. The discovery sheds light on how birds produce feather colors and how hummingbirds evolved their dazzling hues.

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Cartilaginous fish have changed much more in the course of their evolutionary history than previously believed. Evidence for this thesis has been provided by new fossils of a ray-like shark, Protospinax annectans, which demonstrate that sharks were already highly evolved in the Late Jurassic.

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Researchers describe how gut-on-a-chip devices can bridge lab models and human biology. Modeling the microbiome is particularly difficult because of its unique environmental conditions, but through creative design, gut-on-a-chip devices can simulate many of these properties, such as the gut's anaerobic atmosphere, fluid flow, and pulses of contraction/relaxation. Growing intestinal cells in this environment means that they more closely resemble human biology compared to standard laboratory cell cultures.

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Biochemists have succeeded in resurrecting the ancestral genes of five detoxifying enzymes which are present in all tetrapods to show how their divergence in function has occurred.

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By simulating early Earth conditions in the lab, researchers have found that without specific amino acids, ancient proteins would not have known how to evolve into everything alive on the planet today -- including plants, animals, and humans.

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Textbooks will tell you that in dividing cells, production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level. Molecular biologists have now discovered that this is not true: protein synthesis shows two peaks and lipid synthesis peaks once.

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Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years.

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A team of researchers is working to understand the details of the climate for the eastern portion of the United States from the Miocene, which unfortunately is a blank spot on paleo-climate maps. New findings suggest the future climate will be very close to the warmer, wetter, and more homogeneous climate similar to conditions experienced 5 million years ago.

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Influenza viruses are becoming increasingly resilient to medicines. For this reason, new active ingredients are needed. Important findings in this regard have been provided: for the virus to proliferate, the polymerase of the influenza A virus has to be modified many times through enzymes in the host cells. The team of researchers was able to produce a comprehensive map of types of modification. Medicines directed against the enzymes woud be resilient to rapid mutations in the virus, thus offering great potential for the future.

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Plants can move in ways that might surprise you. Some of them even show 'sleep movements,' folding or raising their leaves each night before opening them again the next day. Now, researchers offer convincing evidence for these nightly movements, also known as foliar nyctinasty, in fossil plants that lived more than 250 million years ago.

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A team has developed a method for selectively manipulating genetically engineered cells with ultrasound.

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Geologists doing fieldwork in southeastern Utah's Cedar Mountain Formation found carbon isotope evidence that the site, though on land, experienced the same early Cretaceous carbon-cycle change recorded in marine sedimentary rocks in Europe. This ancient carbon-cycle phenomenon, known as the 'Weissert Event' was driven by large, sustained volcanic eruptions in the Southern Hemisphere that greatly increased carbon dioxide levels in the atmosphere and produced significant greenhouse climate effects over a prolonged time.

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Aetosaurs had a small head and a crocodile-like body. The land dwellers were up to six meters long and widely distributed geographically. They died out about 204 million years ago, at the end of the Triassic. In Germany, an assemblage of 24 Aetosaurus ferratus individuals, only between 20 and 82 centimeters long, was discovered in 1877. Since then, scientists have been puzzling over whether they were juveniles or small adults. A team has now solved the mystery: Bone examination of two specimens shows that they are juveniles.

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About 250 million years ago, the Permian-Triassic mass extinction killed over 80 per cent of the planet's species. In the aftermath, scientists believe that life on earth was dominated by simple species for up to 10 million years before more complex ecosystems could evolve. Now this longstanding theory is being challenged by a team of international researchers.

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The discovery of an 80-million-year-old fossil plant pushes back the known origins of lamiids to the Cretaceous, extending the record of nearly 40,000 species of flowering plants including modern-day staple crops like coffee, tomatoes, potatoes and mint.

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Scientists discovered the first-ever Dickinsonia fossil in India two years ago, changing our understanding of how the continent came to be. Now, new research shows the 'fossil' was just a beehive all along, changing our understanding for a second time, and the original scientists now support the new findings.

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The CT-scanned skull of a 319-million-year-old fossilized fish, pulled from a coal mine in England more than a century ago, has revealed the oldest example of a well-preserved vertebrate brain.