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Categories: Biology: Biotechnology, Paleontology: Fossils

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Two of the closest known relatives to SARS-CoV-2 -- a pair of bat coronaviruses discovered by researchers in Laos -- may transmit poorly in people despite being genetically similar to the COVID-19-causing virus, a new study reveals. The findings provide clues as to why some viruses have greater 'pandemic potential' than others and how researchers might go about identifying those that do before they become widespread.

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Nanozymes are tiny, engineered substances that mimic the catalytic properties of natural enzymes, and they serve a variety of purposes in biomedicine, chemical engineering, and environmental applications. They are typically made from inorganic materials, including metal-based elements, which makes them unsuitable for many purposes due to their toxicity and high production costs. Organic-based nanozymes partially overcome some of these problems and have the potential for a broader range of applications, including food and agriculture, but they are still in the early stages of development. A new paper provides an overview of the current state of organic nanozymes and their future potential.

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Geneticists uncover new insights into how sex chromosome systems work in the platypus and the chicken -- which will lead to better understandings of our own sex chromosome evolution and gene regulation.

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Researchers have modified certain bacteria with UV light so that they produce more cellulose. The basis for this is a new approach with which the researchers generate thousands of bacterial variants and select those that have developed into the most productive.

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Cotton is woven into the very fabric of our lives, from soft T-shirts to comfortable jeans and cozy bedsheets. It's the world's leading renewable textile fiber and the backbone of a global industry worth billions. As climate change intensifies, cotton farmers face increasing challenges from drought and heat. However, new research offers hope for developing more resilient varieties that can maintain high yields even under water-stressed conditions.

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A research team has published a groundbreaking study on malignant catarrhal fever (MCF). This disease is caused by the alcelaphine gammaherpesvirus 1 (AlHV-1), which infects its natural host, the wildebeest. This study sheds light on the mechanisms by which this virus, which is asymptomatic and latent in the wildebeest, causes an oligoclonal expansion of CD8+ T lymphocytes in cattle, leading to the development of MCF.

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The atmosphere, the ocean and life on Earth interacted over the past 500-plus million years in ways that improved conditions for early organisms to thrive. Now, an interdisciplinary team of scientists has produced a perspective article of this co-evolutionary history.

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A study opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The study focuses on tumor necrosis factor- (TNF- ) and its receptors TNFR, molecules of key interest in biomedicine due to their involvement in multiple diseases such as obesity related to type 2 diabetes mellitus, inflammatory bowel disease and several types of cancer.

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Lampreys are one of only two living jawless vertebrates Jaws are formed by a key stem cell population called the neural crest New research reveals the gene regulatory changes that may explain morphological differences between jawed and jawless vertebrates.

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Scientists have discovered a new evasion strategy used by the varicella zoster virus, which causes chickenpox and shingles, that may allow it to affect tissues far from the original site of infection.

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Researchers are working to create the first strain of mice that's genetically susceptible to late-onset Alzheimer's, with potentially transformative implications for dementia research.

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A study looks at the maximum possible sizes of dinosaurs, using the carnivore, Tyrannosaurus rex, as an example. Using computer modelling, experts produced estimates that T. Rex might have been 70% heavier than what the fossil evidence suggests.

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New research has advanced our knowledge of multiple roles for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell-cell adhesion, growth factor signalling and tumor suppression. Through a characterization of the function of PTPRK in human cell lines and mice, the team distinguished catalytic and non-catalytic functions of PTPRK. The findings extend what is known about the signalling mechanisms involving PTPRK as a phosphatase and its role in colorectal health but also shed new light on the extent of its function via non-catalytic signalling mechanisms.

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Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists have used cryo-electron microscopy to observe how lipids and proteins at the plasma membrane interact and react to mechanical stress. This work shows that, depending on conditions, small membrane regions can stabilize various lipids to trigger specific cellular responses. These discoveries confirm the existence of well-organized lipid domains and begin to reveal the role they play in cell survival.

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Palaeontologists are helping resolve the evolution and ecology of Odaraia, a taco-shaped marine animal that lived during the Cambrian period. Fossils reveal Odaraia had mandibles. Palaeontologists are finally able to place it as belonging to the mandibulates, ending its long enigmatic classification among the arthropods since it was first discovered in the Burgess Shale over 100 years ago and revealing more about early evolution and diversification.

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A pilot study shows that nanoscopic 3-D imaging of ancient bone not only provides further insight into the changes soft tissues undergo during fossilization, it also has potential as a fast, practical way to determine which specimens are likely candidates for ancient DNA and protein sequence preservation.

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New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance.

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A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics, researchers report.

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Research reveals that Earth's largest iron ore deposits -- in the Hamersley Province of Western Australia -- are about one billion years younger than previously believed, a discovery which could greatly boost the search for more of the resource.

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Scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody factories that can pump out specially designed antibodies to destroy cancer cells or HIV, two of medicine's most formidable foes.