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Categories: Biology: Biotechnology, Paleontology: Fossils

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New research reveals a chain of environmental disasters. These took place in what is today's South Africa, during an ancient time period called the Early-Middle Devonian. The crises led to the extinction of a unique group of marine animals called the Malvinoxhosan biota.

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Proteins are important molecules that perform a variety of functions essential to life. To function properly, many proteins must fold into specific structures. However, the way proteins fold into specific structures is still largely unknown. Researchers have developed a novel physical theory that can accurately predict how proteins fold. Their model can predict things previous models cannot. Improved knowledge of protein folding could offer huge benefits to medical research, as well as to various industrial processes.

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Baltic amber is a luxury material used in jewellery and handicrafts all over the world. Researchers have shown that Baltic amber arrived on the Iberian Peninsula at least in the 4th millennium BC, more than a millennium earlier than previously thought.

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Yeast cells are widely used to study G protein-coupled receptors (GPCRs), a large group of cell surface proteins in humans. However, several of these proteins lose their function when introduced into yeast cells. To tackle this issue, researchers developed an innovative strategy to restore GPCR function in yeast cells by inducing random mutations. Their findings can help understand GPCRs better and could pave the way to therapeutic breakthroughs for many diseases.

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A research team has discovered that parasites manipulate their hosts using stolen genes that they likely acquired through a phenomenon called horizontal gene transfer.

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Scientists  have developed a genome-scale metabolic model or 'subway map' of key metabolic activities of the bacterium that causes Lyme disease. Using this map, they have successfully identified two compounds that selectively target routes only used by Lyme disease to infect a host.

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New soft, implantable fibers can deliver light to major nerves through the body. They are an experimental tool for scientists to explore the causes and potential treatments for peripheral nerve disorders in animal models.

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Researchers have harnessed the power of baker's yeast to create a cost-effective and highly efficient approach for unraveling how plants synthesize medicinal compounds, and used the new method to identify key enzymes in a kratom tree.

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Formed millions to billions of years ago, diamonds can shine light into the darkest and oldest parts of the Earth's mantle. The analysis of ancient, superdeep diamonds dug up from mines in Brazil and Western Africa, has exposed new processes of how continents evolved and moved during the early evolution of complex life on Earth. These diamonds that were formed between 650 and 450 million years ago on the base of the supercontinent Gondwana, were analysed by an international team of experts, and have shown how supercontinents such as Gondwana were formed, stabilised, and how they move around the planet.

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A microscopic discovery will not only enable scientists to understand the microbial world around us but could also provide a new way to control CRISPR-Cas biotechnologies.

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A research group has developed a new method for studying how cancer cells function in softer and stiffer tissue environments. This insight challenges the existing paradigm, opening up new possibilities for research in cancer biology and tissue engineering.

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Whaling in the 20th century destroyed 99% of the Eastern North Pacific fin whale breeding population. Because there is enough genetic diversity, current conservation measures should help the population rebound without becoming inbred. The future of fin whales in the Gulf of California depends on the recovery of the Eastern North Pacific population.

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The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. The stability of the duplex can be fine-tuned in the lab by controlling the amount and location of imperfect complementary sequences. Fluorescent markers bound to one of the matching DNA strands make the duplex visible, and fluorescence intensity increases with increasing duplex stability. Now, researchers have succeeded in creating fluorescent duplexes that can generate any of 16 million colors -- a work that surpasses the previous 256 colors limitation. This very large palette can be used to 'paint' with DNA and to accurately reproduce any digital image on a miniature 2D surface with 24-bit color depth.

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Using cryo-electron microscopy (cryo-EM), researchers captured unprecedented images of key immune system receptors interacting with messenger proteins, elucidating how the receptors change shape upon activation and transmit signals within the cell. The findings suggest new pathways for developing therapeutic molecules for diseases such as COVID-19, rheumatoid arthritis, neurodegenerative diseases and cancer.

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The legendary Alexander Fleming, who famously discovered penicillin, once said 'never to neglect an extraordinary appearance or happening.' And the path of science often leads to just that. New research is turning the page in our understanding of harmful bacteria and how they turn on certain genes, causing disease in our bodies.

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In the world of threatened and endangered species conservation, the genomic revolution has raised some complicated questions: How can scientists justify assessing species genetic diversity without consulting entire genomes now that they can be sequenced? But then again, how can scientists justify the time and expense of genome sequencing when age-old measures of neutral genetic diversity are much cheaper and easier to obtain? A new study suggests making a transition from 'old school' genetics to 'new school' genomics for species conservation purposes probably isn't necessary in all cases.

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Researchers have discovered how the fungus Candida albicans enters the brain, activates two separate mechanisms in brain cells that promote its clearance, and, important for the understanding of Alzheimer's disease development, generates amyloid beta (Ab)-like peptides, toxic protein fragments from the amyloid precursor protein that are considered to be at the center of the development of Alzheimer's disease.

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A new study has reconstructed the well-preserved but damaged skull of a great ape species that lived about 12 million years ago. The species, Pierolapithecus catalaunicus, may be crucial to understanding great ape and human evolution.

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A bacterium found in the sea can degrade a plastic that otherwise resists microbial breakdown in marine environments.

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The heat shock response of cells is a classic model of biological adaptation, part of the fundamental processes of life -- conserved in creatures from single-celled yeast to humans -- that allow our cells to adjust to changing conditions in their environment. For years, scientists have focused on how different genes respond to heat stress to understand this survival technique. Now, thanks to the innovative use of advanced imaging techniques, researchers are getting an unprecedented look at the inner machinery of cells to see how they respond to heat stress.