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Categories: Biology: Biotechnology, Paleontology: Fossils
Published New open-source method to improve decoding of single-cell data
(via sciencedaily.com) Original source Researchers have developed a new open-source computational method, dubbed Spectra, which improves the analysis of single-cell transcriptomic data. By guiding data analysis in a unique way, Spectra can offer new insights into the complex interplay between cells — like the interactions between cancer cells and immune cells, which are critical to improving immunotherapy treatments.
Published Ruffed grouse population more resilient than expected, genetic study finds
(via sciencedaily.com) Original source Despite decades of decline, a genetic analysis of ruffed grouse reveals that Pennsylvania's state bird harbors more genetic diversity and connectivity than expected. The findings suggest that the iconic game bird could be maintained in persistent numbers if appropriate protections are implemented.
Published New type of tiny wasp comes with mysterious, cloud-like structures at ends of antennae
(via sciencedaily.com) Original source Fossil researchers have discovered a novel genus and species of tiny wasp with a mysterious, bulbous structure at the end of each antenna.
Published Proteins roll the dice to determine bee sex
(via sciencedaily.com) Original source To date it has been unclear exactly how the sex of a bee is determined. A research team comprising biologists and chemists has now identified a key gene and the molecular mechanism linked with it. They describe how this process is similar to a game involving two dice.
Published Avatars to help tailor glioblastoma therapies
(via sciencedaily.com) Original source Scientists have created a new zebrafish xenograft platform to screen for novel treatments for an aggressive brain tumor called glioblastoma, according to a new study.
Published Honeybees are more selective in their choices for nutrition than previously thought
(via sciencedaily.com) Original source An international research group examined which plants honeybees favor when collecting nectar and pollen. The choices honeybees make have an impact on their health and also on humans, as honeybees pollinate important crop plants.
Published Ancient technology turns plant-based cheese into 'something we want to eat'
(via sciencedaily.com) Original source To produce plant-based cheeses that feel and taste like dairy cheese, scientists have their sights set on fermentation. In a new research result, scientists demonstrate the potential of fermentation for producing climate-friendly cheeses that people want to eat.
Published Scientists develop 3D printing method that shows promise for repairing brain injuries
(via sciencedaily.com) Original source Researchers have produced an engineered tissue representing a simplified cerebral cortex by 3D printing human stem cells. When implanted into mouse brain slices, the structures became integrated with the host tissue. The technique may ultimately be developed into tailored repairs to treat brain injuries.
Published When cells go boom: Study reveals inflammation-causing gene carried by millions
(via sciencedaily.com) Original source Researchers have found that a genetic change that increases the risk of inflammation, through a process described as ‘explosive’ cell death, is carried by up to 3% of the global population.
Published DNA from discarded whale bones suggests loss of genetic diversity due to commercial whaling
(via sciencedaily.com) Original source Commercial whaling in the 20th century decimated populations of large whales but also appears to have had a lasting impact on the genetic diversity of today’s surviving whales, new research shows.
Published Preventing spread of parasitic DNA in our genomes
(via sciencedaily.com) Original source Researchers have identified a new enzyme called PUCH, which plays a key role in preventing the spread of parasitic DNA in our genomes. These findings may reveal new insights into how our bodies detect and fight bacteria and viruses to prevent infections.
Published Water makes all the difference
(via sciencedaily.com) Original source Water is a major driving force in the formation of separate reaction compartments within cells.
Published A hygiene program for chromosomes
(via sciencedaily.com) Original source Researchers identified and characterized a new cellular compartment in vertebrate cells that might be a precursor of today's eucaryotic nucleus. The study reveals that mammalian cells recognize, cluster, sort and keep extrachromosomal DNA -- like transfected plasmid DNA and endogenous circular DNAs originating from telomeres of the chromosome -- away from chromosomal DNA. That suggests that there is a cell autonomous genome defense system.
Published Researchers studied thousands of fertility attempts hoping to improve IVF
(via sciencedaily.com) Original source By genetically testing nearly one thousand embryos, scientists have provided the most detailed analysis of embryo fate following human in vitro fertilization.
Published Small but mighty new gene editor
(via sciencedaily.com) Original source A new CRISPR-based gene-editing tool has been developed which could lead to better treatments for patients with genetic disorders. The tool is an enzyme, AsCas12f, which has been modified to offer the same effectiveness but at one-third the size of the Cas9 enzyme commonly used for gene editing. The compact size means that more of it can be packed into carrier viruses and delivered into living cells, making it more efficient.
Published Gut inflammation caused by substance secreted by microbe
(via sciencedaily.com) Original source A rare subtype of the world's most common parasite, Blastocystis, has been found to produce a unique by-product of its metabolism, which can cause gut inflammation under normal gut conditions.
Published Insights into early snake evolution through brain analysis
(via sciencedaily.com) Original source Recent study sheds new light on the enigmatic early evolution of snakes by examining an unexpected source: their brains. The results emphasize the significance of studying both the soft parts of animals’ bodies and their bones for understanding how animals evolved.
Published Timing plant evolution with a fast-ticking epigenetic clock
(via sciencedaily.com) Original source Recent discoveries in the field of epigenetics, the study of inheritance of traits that occur without changing the DNA sequence, have shown that chronological age in mammals correlates with epigenetic changes that accumulate during the lifetime of an individual. In humans, this observation has led to the development of epigenetic clocks, which are now extensively used as biomarkers of aging. While these clocks work accurately from birth until death, they are set back to zero in each new generation. Now, an international team shows that epigenetic clocks not only exist in plants, but that these clocks keep ticking accurately over many generations.
Published A lethal parasite's secret weapon: Infecting non-immune cells
(via sciencedaily.com) Original source The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.
Published An advance in cryo-EM could be a significant boon for research on potential cancer therapies
(via sciencedaily.com) Original source A technology called cryo-electron microscopy enables scientists to see the atomic structure of biological molecules in high resolution. But to date, it has been ineffective for imaging small molecules. A team of biochemists devised a solution that makes it possible to hold small protein molecules in place while they're being imaged, which will enable cryo-EM to produce much clearer images of such molecules. The advance is significant because small and medium-sized protein molecules are an area of focus in research on potential new drugs for cancer and other diseases.