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Categories: Biology: Biotechnology, Offbeat: Computers and Math
Published Say 'aah' and get a diagnosis on the spot: is this the future of health?



A computer algorithm has achieved a 98% accuracy in predicting different diseases by analyzing the color of the human tongue. The proposed imaging system can diagnose diabetes, stroke, anemia, asthma, liver and gallbladder conditions, COVID-19, and a range of vascular and gastrointestinal issues, according to new research.
Published Pit-building venom mixers



Researchers show that the adaptation of antlions to their ecological niche has also changed their venom. They compared the venom system of antlion and closely related green lacewing larvae. Antlions produce a much more complex venom from three different venom glands than lacewing larvae do. All the venom proteins identified come from the insects themselves, not from symbiotic bacteria. Some of the toxins are new and appear to be unique to antlions. Waiting for their victims in pitfall traps in the sand, antlions can use their venom to immobilize larger prey. The venom therefore plays an important ecological role in adapting to their barren habitat.
Published Surprising insight into cancer comes from unique plant species that find different solutions to evolutionary challenges



A study has shown that different plant species tackle the same evolutionary hurdle in different ways, and the findings may give insight into aggressive forms of cancer.
Published Reduce, reuse, 're-fly-cle'



Black soldier flies are now commercially used to consume organic waste -- but genetic modifications proposed by bioscientists could see the insects digesting a wider variety of refuse, while also creating raw ingredients for industry.
Published Engineers make tunable, shape-changing metamaterial inspired by vintage toys



Common push puppet toys in the shapes of animals and popular figures can move or collapse with the push of a button at the bottom of the toys' base. Now, a team of engineers has created a new class of tunable dynamic material that mimics the inner workings of push puppets, with applications for soft robotics, reconfigurable architectures and space engineering.
Published AI poses no existential threat to humanity, new study finds



Large Language Models (LLMs) are entirely controllable through human prompts and lack 'emergent abilities'; that is, the means to form their own insights or conclusions. Increasing model size does not lead LLMs to gain emergent reasoning abilities, meaning they will not develop hazardous abilities and therefore do not pose an existential threat. A new study sheds light on the (until now unexplained) capabilities and shortcomings of LLMs, including the need for carefully engineered prompts to exhibit good performance.
Published Researchers ID body's 'quality control' regulator for protein folding



Anyone who's tried to neatly gather a fitted sheet can tell you: folding is hard. Get it wrong with your laundry and the result can be a crumpled, wrinkled mess of fabric, but when folding fails among the approximately 7,000 proteins with an origami-like complexity that regulate essential cellular functions, the result can lead to one of a multitude of serious diseases ranging from emphysema and cystic fibrosis to Alzheimer's disease. Fortunately, our bodies have a quality-control system that identifies misfolded proteins and marks them either for additional folding work or destruction, but how, exactly, this quality-control process functions is not entirely known. Researchers have now made a major leap forward in our understanding of how this quality-control system works by discovering the 'hot spot' where all the action takes place.
Published Low magnesium levels increase disease risk



A new study has identified why a diet rich in magnesium is so important for our health, reducing the risk of DNA damage and chronic degenerative disorders.
Published Taking a 'one in a million' shot to tackle dopamine-linked brain disorders



With the help of a tiny, transparent worm called Caenorhabditis elegans, researchers have identified novel players in dopamine signaling by taking advantage of a powerful platform generated via the Million Mutation Project (MMP) for the rapid identification of mutant genes based on their functional impact. They can seek insights from simpler organisms whose genes bear striking similarity to those found in humans and where opportunities for genetic insights to disease can be pursued more efficiently and inexpensively.
Published An appetizer can stimulate immune cells' appetite, a boon for cancer treatments



The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer. Chief among this force is the macrophage, a white blood cell that surveils tissues and consumes pathogens, debris, dead cells, and cancer. Macrophages have a delicate task. It's crucial that they ignore healthy cells while on patrol, otherwise they could trigger an autoimmune response while performing their duties.
Published New genetically engineered wood can store carbon and reduce emissions



Researchers genetically modified poplar trees to produce high-performance, structural wood without the use of chemicals or energy intensive processing.
Published Engineers bring efficient optical neural networks into focus



Researchers have published a programmable framework that overcomes a key computational bottleneck of optics-based artificial intelligence systems. In a series of image classification experiments, they used scattered light from a low-power laser to perform accurate, scalable computations using a fraction of the energy of electronics.
Published A new mechanism for shaping animal tissues



A key question that remains in biology and biophysics is how three-dimensional tissue shapes emerge during animal development. Research teams have now found a mechanism by which tissues can be 'programmed' to transition from a flat state to a three-dimensional shape.
Published New two-step flu vaccine strategy shows promise in pig model



A new, two-step flu vaccination strategy that pairs intramuscular injection of a viral vectored flu vaccine with nasal spray administration of a novel attenuated live flu virus appears to be safe and effective in pigs, researchers report.
Published Largest protein yet discovered builds algal toxins



While seeking to unravel how marine algae create their chemically complex toxins, scientists have discovered the largest protein yet identified in biology. Uncovering the biological machinery the algae evolved to make its intricate toxin also revealed previously unknown strategies for assembling chemicals, which could unlock the development of new medicines and materials.
Published Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy



Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient. Now, researchers have developed a machine-learning approach that promises to speed up AAV engineering for gene therapy. The tool helps researchers engineer the protein shells of AAVs, called capsids, to have multiple desirable traits, such as the ability to deliver cargo to a specific organ but not others or to work in multiple species. Other methods only look for capsids that have one trait at a time.
Published Bacteria encode hidden genes outside their genome--do we?



A 'loopy' discovery in bacteria is raising fundamental questions about the makeup of our own genome -- and revealing a potential wellspring of material for new genetic therapies.
Published Researchers develop AI model that predicts the accuracy of protein--DNA binding



A new artificial intelligence model can predict how different proteins may bind to DNA.
Published Achieving quantum memory in the hard X-ray range



Physicists have used Doppler-shifted nuclear resonant absorbers to form a nuclear frequency comb, enabling a quantum memory in the notoriously difficult X-ray range.
Published Researchers make breakthrough in understanding species abundance



The key finding was that temperature and genome size, not body size, had the greatest influence on the maximum population growth rate of the diatoms. Yet body size still mattered in colder latitudes, conserving Bermann's Rule.