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Categories: Biology: Cell Biology, Chemistry: Organic Chemistry
Published Heating proteins to body temperature reveals new drug targets
(via sciencedaily.com) Original source Some proteins shift their shape when exposed to different temperatures, revealing previously unknown binding sites for medications. The findings could revolutionize wide swathes of biology by fundamentally changing how protein structure is studied and leveraged for drug design.
Published Now we know, what gets roots to grow: Can help in future droughts
(via sciencedaily.com) Original source A biological mechanism familiar to people who fast helps plant roots grow strong. The discovery provides an answer to a long-unanswered question and a deeper understanding of the 'mouths' of plants that can help to develop climate-resilient crops.
Published An active agent against hepatitis E
(via sciencedaily.com) Original source At present, there is no specific active substance against hepatitis E. As the disease kills 70,000 people every year, researchers are actively searching for one. A team may have found what they're looking for. The researchers showed that the compound K11777 prevents host cells from helping the virus out of its shell by cleaving the viral capsid. This means it can no longer infect cells.
Published Exploring the mechanism behind drug eruptions in the skin
(via sciencedaily.com) Original source Although drug eruptions are often linked to the human leukocyte antigen (HLA), the mechanism of its involvement in presenting symptoms of the skin remains unclear. In a recent study, researchers used genetically engineered mice to demonstrate the role of HLA in mediating intracellular reactions in keratinocytes, leading to drug eruptions in the skin. Their findings could lead to improved preventive and treatment measures for drug eruptions.
Published Polyglycerol coating: A breakthrough in safer nanoparticle environmental remediation
(via sciencedaily.com) Original source Engineered nanoparticles (NPs), commonly utilized in environmental remediation, can pose significant toxicity risks upon ingestion by organisms. Researchers have now devised a solution to this challenge by creating a hydrophilic coating, utilizing polyglycerol (PG) functionalization, for NPs. This coating effectively prevents NP aggregation inside organisms' bodies and facilitates easier passage, thereby reducing accumulation. Applicable to various NPs, the novel surface functionalization approach holds promise for addressing concerns about NP toxicity in environmental remediation.
Published Drug compounds to combat neurodegenerative diseases
(via sciencedaily.com) Original source Prions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins. Prion disease is an umbrella term for a group of fatal and currently untreatable neurodegenerative diseases that not only affect humans, but also wild and captive animals. These diseases include Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy (BSE, or 'mad cow disease'), and chronic wasting disease (CWD) affecting deer, elk and moose.
Published Some mice may owe their monogamy to a newly evolved type of cell
(via sciencedaily.com) Original source What makes the oldfield mouse steadfastly monogamous throughout its life while its closest rodent relatives are promiscuous? The answer may be a previously unknown hormone-generating cell. Scientists discover the cells and hormones that inspire mice to nurture their young; the same hormones are also present in humans.
Published Next-generation sustainable electronics are doped with air
(via sciencedaily.com) Original source Semiconductors are the foundation of all modern electronics. Now, researchers have developed a new method where organic semiconductors can become more conductive with the help of air as a dopant. The study is a significant step towards future cheap and sustainable organic semiconductors.
Published Bio-based resins could offer recyclable future for 3D printing
(via sciencedaily.com) Original source A new type of recyclable resin, made from biosourced materials, has been designed for use in 3D printing applications.
Published Promising new development in solar cell technology
(via sciencedaily.com) Original source Researchers who contributed to the development of record-breaking solar cells a few years ago, expanded their invention. The self-assembled monolayers can now be applied not only in inverted but also in regular structure perovskite solar cells.
Published Genetics provide key to fight crown-of-thorns starfish
(via sciencedaily.com) Original source Scientists are one step closer to combating coral-destroying crown-of-thorns starfish, following a study into the pest's genetics.
Published Far from toxic, lactate rivals glucose as body's major fuel after a carbohydrate meal
(via sciencedaily.com) Original source Scientists have documented the benefits of lactate burning in exercising humans, but few studies have looked at the role of lactate during rest or after a meal. Exercise physiologists challenged fasting men and women with a carbohydrate meal and then monitored lactate in the blood and fat vs carbohydrate metabolism. They found that lactate buffers glucose from a meal, and that lactate is utilized for energy almost as much as glucose.
Published Virus that causes COVID-19 can penetrate blood-retinal barrier and could damage vision
(via sciencedaily.com) Original source Researchers have discovered the virus that causes COVID-19 can breach the protective blood-retinal-barrier with potential long-term consequences in the eye.
Published High genetic diversity discovered in South African leopards
(via sciencedaily.com) Original source Researchers say the discovery of very high genetic diversity in leopards found in the Highveld region of South Africa has increased the need for conservation efforts to protect leopards in the country.
Published Eco-friendly and affordable battery for low-income countries
(via sciencedaily.com) Original source A battery made from zinc and lignin that can be used over 8000 times. This has been developed with a vision to provide a cheap and sustainable battery solution for countries where access to electricity is limited.
Published Avocado pruning residues used to produce more sustainable food packaging
(via sciencedaily.com) Original source A prototype of a more durable material increases the biodegradability of food packaging, partially replacing its bioplastic with cellulose fibers extracted from the branches and leaves of the avocado tree.
Published Creating a green composite material from Japanese washi paper
(via sciencedaily.com) Original source Japanese washi paper is renowned for its aesthetic beauty and its wide-array of usages. Now, a group of researchers have made a green composite material from washi which boasts a 60% increase in strength as well as being more biodegradable. They hope that their research will revive interest in this traditional craft.
Published How to make ubiquitous plastics biodegradable
(via sciencedaily.com) Original source Polystyrene is made from styrene building blocks and is the most widely used plastic in terms of volume, for example in packaging. Unlike PET, which can now be produced and recycled using biotechnological methods, the production of polystyrene has so far been a purely chemical process. The plastic can't be broken down by biotechnological means, either. Researchers are looking for ways to rectify this: An international team decoded a bacterial enzyme that plays a key role in styrene degradation. This paves the way for biotechnological application.
Published Persistent strain of cholera defends itself against forces of change, scientists find
(via sciencedaily.com) Original source A longstanding mystery about the strain of Vibrio cholerae (V. cholerae) responsible for the seventh global cholera pandemic is how this lineage has managed to out-compete other pathogenic variants. The team identified a unique quirk of the immune system that protects the bacteria from a key driver of bacterial evolution.
Published Insights into protein evolution
(via sciencedaily.com) Original source A research team has unveiled a breakthrough in understanding how specific genetic sequences, known as pseudogenes, evolve.