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Categories: Biology: Cell Biology, Chemistry: Organic Chemistry
Published New and improved way to grow the cells that give rise to the kidney's filtration system
(via sciencedaily.com) Original source Scientists report significant progress in cultivating nephron progenitor cells (NPCs), the cells destined to form the kidney's filtration system, the nephrons. NPCs hold immense promise for understanding kidney development, modeling diseases, and discovering new treatments. The team improved the chemical cocktail for generating and growing NPCs in the laboratory, enabling the sustained growth of both mouse and human NPCs in a simple 2-dimensional format.
Published Researchers parse oddity of distantly related bats in Solomon Islands that appear identical
(via sciencedaily.com) Original source A study of body size in leaf-nosed bats of the Solomon Islands has revealed surprising genetic diversity among nearly indistinguishable species on different islands.
Published Discovery of mechanism plants use to change seed oil could impact industrial, food oils
(via sciencedaily.com) Original source Researchers have discovered a new mechanism of oil biosynthesis and found a way to genetically engineer a type of test plant to more efficiently produce different kinds of seed oil that it otherwise wouldn't make. While the engineering is proof-of-concept, this discovery could lead to improved production of valuable oils used in food and by a range of industries. The modified plant overcame metabolic bottlenecks and produced significant amounts of an oil similar to castor oil that it doesn't naturally produce.
Published Unlocking the genetic mysteries behind plant adaptation: New insights into the evolution of a water-saving trait in the pineapple family (bromeliaceae)
(via sciencedaily.com) Original source Researchers have achieved a breakthrough in understanding how genetic drivers influence the evolution of a specific photosynthesis mechanism in Tillandsia (air plants). This sheds light on the complex actions that cause plant adaptation and ecological diversity.
Published Trotting robots reveal emergence of animal gait transitions
(via sciencedaily.com) Original source A four-legged robot trained with machine learning has learned to avoid falls by spontaneously switching between walking, trotting, and pronking -- a milestone for roboticists as well as biologists interested in animal locomotion.
Published Research on RNA editing illuminates possible lifesaving treatments for genetic diseases
(via sciencedaily.com) Original source The research explores how CRISPR can be used to edit RNA.
Published One in eight grown-ups love extreme tartness
(via sciencedaily.com) Original source For most people, biting into a lemon would leave them puckered up and desperate to lose that sour flavor, but a new study revealed that roughly one in eight adults like intensely sour sensations. The cross-cultural study demonstrated there is a subset of 'sour likers' who enjoy exceptionally sour foods.
Published Possible alternative to antibiotics produced by bacteria
(via sciencedaily.com) Original source Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment. Researchers have discovered a new so-called lantibiotic, namely epilancin A37. It is produced by staphylococci that colonize the skin and acts specifically against their main competitors there, the corynebacteria. This specificity is presumably mediated by a very special mechanism of action, which the researchers were able to decipher in detail.
Published More plants on the menu of ancient hunter-gatherers
(via sciencedaily.com) Original source It has long been thought that meat played an important role in the diet of hunter-gatherers before the Neolithic transition. However, due to the scarcity of well-preserved human remains from Paleolithic sites, little information exists about the dietary habits of pre-agricultural human groups. A new study challenges this notion by presenting compelling isotopic evidence of a strong preference for plants among 15,000-year-old hunter-gatherers from Morocco. This is the first time a significant amount of plant consumption has been measured for a pre-agricultural population, shedding new light on the dietary practices of ancient human societies.
Published When does a conductor not conduct?
(via sciencedaily.com) Original source A new study uncovers a switchable, atomically-thin metal-organic material that could be used in future low-energy electronic technologies. The study shows that electron interactions in this material create an unusual electrically-insulating phase in which electrons are 'frozen'. By reducing the population of electrons, the authors are able to unfreeze the remaining electrons, allowing for controlled transitions between insulating and electrically-conductive phases: the key to the on-off binary operations of classical computing.
Published Fixin' to be flexitarian: Scrap fish and invasive species can liven up vegetables
(via sciencedaily.com) Original source Greening the way we eat needn't mean going vegetarian. A healthy, more realistic solution is to adopt a flexitarian diet where seafoods add umami to 'boring' vegetables. A gastrophysicist puts mathematical equations to work in calculating the umami potential of everything from seaweed and shrimp paste to mussels and mackerel.
Published Study details a common bacterial defense against viral infection
(via sciencedaily.com) Original source Researchers report on the molecular assembly of one of the most common anti-phage systems -- from the family of proteins called Gabija -- that is estimated to be used by at least 8.5%, and up to 18%, of all bacteria species on Earth.
Published Mobile device location data is already used by private companies, so why not for studying human-wildlife interactions
(via sciencedaily.com) Original source When did you last go anywhere without your cell phone? From maps and weather apps to social media platforms, we give consent for our phones to trace our footsteps and behavior. These curated mobility data are often used for personalized advertisements. Scientists now argue mobility data can offer so much more -- it is key to understanding human-wildlife interactions for guiding policy decisions on sustainability-related issues and should be free and accessible for research.
Published Getting dynamic information from static snapshots
(via sciencedaily.com) Original source Researchers have created TopicVelo, a powerful new method of using the static snapshots from scRNA-seq to study how cells and genes change over time. This will help researchers better study how embryos develop, cells differentiate, cancers form, and the immune system reacts.
Published Surprising evolutionary pattern in yeast study
(via sciencedaily.com) Original source Research study reports intriguing findings made through innovative artificial intelligence analysis about yeasts -- small fungi that are key contributors to biotechnology, food production, and human health. These findings on simple yeast organisms not only challenge widely accepted ideas about yeast evolution, but also provides access to an incredibly rich yeast analysis dataset that could have major implications for future evolutionary biology and bioinformatics research for years to come.
Published Genetic hope in fight against devastating wheat disease
(via sciencedaily.com) Original source Fungal disease Fusarium head blight (FHB) is on the rise due to increasingly humid conditions induced by climate change during the wheat growing season, but a fundamental discovery could help reduce its economic harm.
Published Barley plants fine-tune their root microbial communities through sugary secretions
(via sciencedaily.com) Original source Different types of barley recruit distinct communities of soil microbes to grow around their roots by releasing a custom mix of sugars and other compounds, according to a new study.
Published A shortcut for drug discovery
(via sciencedaily.com) Original source For most human proteins, there are no small molecules known to bind them chemically (so called 'ligands'). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines. Researchers at CeMM, in a collaboration with Pfizer, have now leveraged and scaled a method to measure the binding activity of hundreds of small molecules against thousands of human proteins. This large-scale study revealed tens of thousands of ligand-protein interactions that can now be explored for the development of chemical tools and therapeutics. Moreover, powered by machine learning and artificial intelligence, it allows unbiased predictions of how small molecules interact with all proteins present in living human cells. These groundbreaking results have been published in the journal Science (DOI: 10.1126/science.adk5864), and all generated data and models are freely available for the scientific community.
Published Food in sight? The liver is ready!
(via sciencedaily.com) Original source What happens in the body when we are hungry and see and smell food? A team of researchers has now been able to show in mice that adaptations in the liver mitochondria take place after only a few minutes. Stimulated by the activation of a group of nerve cells in the brain, the mitochondria of the liver cells change and prepare the liver for the adaptation of the sugar metabolism. The findings could open up new avenues for the treatment of type 2 diabetes.
Published Curiosity promotes biodiversity
(via sciencedaily.com) Original source Cichlid fishes exhibit differing degrees of curiosity. The cause for this lies in their genes, as reported by researchers. This trait influences the cichlids' ability to adapt to new habitats.