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Categories: Biology: Cell Biology, Chemistry: Organic Chemistry

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At first glance, Rabih Al-Kaysi's molecular motors look like the microscopic worms you'd see in a drop of pond water. But these wriggling ribbons are not alive; they're made from crystallized molecules that perform coordinated movements when exposed to light. With continued development, these tiny machines could be used as drug-delivery robots or engineered into arrays that direct the flow of water around submarines.

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Water pollution from dyes used in textile, food, cosmetic and other manufacturing is a major ecological concern with industry and scientists seeking biocompatible and more sustainable alternatives to protect the environment. A new study has discovered a novel way to degrade and potentially remove toxic organic chemicals including azo dyes from wastewater, using a chemical photocatalysis process powered by ultraviolet light.

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Researchers have discovered that the mere act of attaching their microparticle 'backpacks' to neutrophils is enough to activate them against cancer -- no drugs needed. In experiments, backpack-bearing neutrophils shrank tumors and extended the survival of mice with cancer, and treated animals retained an immune memory of the disease. This approach opens the door to a new class of drug-free immunotherapy for cancer.

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In a series of trials involving trained distance runners, researchers found that ingesting a cranberry supplement for 28 consecutive days led to noticeable improvements in both performance and muscle fatigue following 1,500-metre time trials. Reoxygenation rates were faster and running speeds improved by 1.5 per cent. The researchers found that 28 days of cranberry extract consumption by elite level endurance runners demonstrated a trend toward increased speed in 1,500-metre time trials but not in 400-metre ones. However, they did notice that lactate buildup was reduced following the 400-metre but not the 1,500-metre compared to baseline. The data also indicated that the cranberry extract promoted better oxygen extraction by the muscle, improved lactate clearance and slower muscle deoxygenation.

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Human sweat contains a protein that may protect against Lyme disease. About one-third of the population carries a genetic variant of this protein that is associated with Lyme disease in genome-wide association studies.

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Researchers have made very fast and very precise images of excitons -- in fact, accurate to one quadrillionth of a second and one billionth of a meter. This understanding is essential for developing more efficient materials with organic semiconductors.

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Some soil bacteria can acquire sets of genes that enable them to pump the heavy metal nickel out of their systems, a study has found. This enables the bacteria to not only thrive in otherwise toxic soils but help plants grow there as well. A research team pinpointed a set of genes in wild soil bacteria that allows them to do this in serpentine soils which have naturally high concentrations of toxic nickel. The genetic discovery could help inform future bioremediation efforts that seek to return plants to polluted soils.

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Heparin, the world's most widely used blood thinner, is used during procedures ranging from kidney dialysis to open heart surgery. Currently, heparin is derived from pig intestines, but scientists have discovered how to make it in the lab. They have also developed a path to a biomanufacturing process that could potentially revolutionize how the world gets its supply of this crucial medicine.

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A new report uncovers how hydrogen gas, the energy of the future, provided energy in the past, at the origin of life 4 billion years ago. Hydrogen gas is clean fuel. It burns with oxygen in the air to provide energy with no CO2. Hydrogen is a key to sustainable energy for the future. Though humans are just now coming to realize the benefits of hydrogen gas (H2 in chemical shorthand), microbes have known that H2 is good fuel for as long as there has been life on Earth. Hydrogen is ancient energy.

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Our eating habits in industrialized societies are far removed from those of ancient humans. This is impacting our intestinal flora, it seems, as newly discovered cellulose degrading bacteria are being lost from the human gut microbiome, especially in industrial societies.

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The development of hair was of central importance for the evolution of mammals and thus also of humans. However, the evolutionary origin of the genetic program of hair was previously unknown. Researchers have now been able to show that important hair components and their genetic control have already evolved in amphibians. Human hair therefore shows unexpected similarities to the claws of clawed frogs.

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The curvature of a surface determines the migration behavior of biological cells. They preferentially move along valleys or grooves while avoiding ridges. These findings gave rise to a model predicting cellular behavior. Such universal principles now allow a better understanding of the migration of immune and cancer cells, paving the way for new treatment options.

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In a first for the condensate field, researchers have figured out how nucleolar sub-structures are assembled. This organization gives rise to unique pH profiles within nucleoli, which they measured and compared with the pH of nearby non-nucleolar condensates including nuclear speckles and Cajal bodies.

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Eating fatty food in the days leading up to surgery may prompt a heightened inflammatory response in the brain that interferes for weeks with memory-related cognitive function in older adults -- and, new research in animals suggests, even in young adults.

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Research has demonstrated individual differences in and successfully extracted commonalities from the whole-brain activity of roundworms. The researchers also found that computer simulations based on the whole-brain activity of roundworms more accurately reflect real-brain activity when they include so-called 'noise,' or probabilistic elements.

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Researchers have created a DNA origami platform called DoriVac, whose core component is a self-assembling square block-shaped nanostructure. DoriVac vaccines enabled tumor-bearing mice to better control the growth of tumors and to survive significantly longer than control mice.

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A printable organic polymer that assembles into chiral structures when printed has enabled researchers to reliably measure the amount of charge produced in spin-to-charge conversion within a spintronic material at room temperature.

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Making a personalized T cell therapy for cancer patients currently takes at least six months. Scientists have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.

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Perfectly adapted microorganisms live in extreme environments from deep-sea trenches to mountaintops. Learning more about how these extremophiles survive in hostile conditions could inform scientists about life on Earth and potential life on other planets.

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Automated insulin dosing systems combine low-cost blood-glucose monitors with insulin pumps that use precision dosing to continuously regulate blood-sugar and hold it steady. Synthetic biologists have found a way to piggyback on the technology and make it universally applicable for the precision dosing of virtually any drug.