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Categories: Biology: Cell Biology, Energy: Batteries
Published Editing without 'cutting': Molecular mechanisms of new gene-editing tool revealed
(via sciencedaily.com) Original source New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix. Clarifying these molecular mechanisms contributes greatly to designing gene-editing tools accurate enough for gene therapy treatments.
Published Chicken feathers to deliver chemotherapy drugs and repair enzymes
(via sciencedaily.com) Original source A new method of drug delivery using proline, an amino acid found in chicken feathers and skin tissue, could be used to limit the side effects of chemotherapy and repair important enzymes, new research suggests.
Published Acute sense of touch helps hummingbirds hover near a flower without bumping into it
(via sciencedaily.com) Original source Hummingbird flight mechanics have been well studied but far less is known about how their sense of touch helps them sip nectar from a flower without bumping into it. Most of what scientists know about how touch is processed in the brain comes from studies on mammals, but bird brains are very different from mammal brains. New research shows that touch and air pressure on the wings and legs activate specific clusters of neurons in two regions of the forebrain to create a map of their body, which may help hummingbirds make nuanced adjustments to flight.
Published Complete X and Y chromosome sequences of living great ape species determined
(via sciencedaily.com) Original source Newly generated, complete genomes for the sex chromosomes of six primate species may inform conservation of these endangered species and shed light on sex-related genetic diseases in both humans and our closest living relatives.
Published New antibiotic kills pathogenic bacteria, spares healthy gut microbes
(via sciencedaily.com) Original source Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides difficile, a common and dangerous hospital-associated bacterial infection, and was effective against more than 130 multidrug-resistant bacterial strains in cell culture.
Published New research approach: Exploring the mouthfeel of food with a microscope
(via sciencedaily.com) Original source A new perspectives article focuses on different ways to study the mouthfeel of food using atomic force microscopy to better understand the biophysical mechanisms that contribute to taste sensations in a broader sense. New findings in this area could drive the development of health-promoting products that contain less salt, fat, sugar and calories but still have a convincing mouthfeel.
Published Heart healthy behaviors may help reverse rapid cell aging
(via sciencedaily.com) Original source The benefits gained with higher lifestyle scores may be associated with the positive influence of heart disease risk factors on the aging of the body and its cells, finds a new study in the Journal of the American Heart Association
Published Polymeric films protect anodes from sulfide solid electrolytes
(via sciencedaily.com) Original source Researchers unveil the interaction between polymeric materials and sulfide solid electrolytes.
Published Bird flu: Diverse range of vaccines platforms 'crucial' for enhancing human pandemic preparedness
(via sciencedaily.com) Original source Review of research to-date suggests vaccination remains the most effective strategy for avian influenza prevention and control in humans, despite varying vaccine efficacy across strains.
Published Intermittent fasting shows promise in improving gut health, weight management
(via sciencedaily.com) Original source Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses. These benefits were notably greater than those seen with simple calorie restriction. The findings could advance our understanding of the relationship between the gut microbiome and metabolism and improve strategies for managing obesity.
Published Scientists identify gene that could lead to resilient 'pixie' corn
(via sciencedaily.com) Original source A widely found gene in plants has been newly identified as a key transporter of a hormone that influences the size of corn. The discovery offers plant breeders a new tool to develop desirable dwarf varieties that could enhance the crop's resilience and profitability.
Published When should you neuter or spay your dog?
(via sciencedaily.com) Original source A new study updates guidelines for when you should neuter or spay your dog to prevent increased risk of cancer or joint disorders.
Published Bringing back an ancient bird
(via sciencedaily.com) Original source Using ancient DNA extracted from the toe bone of a museum specimen, biologists have sequenced the genome of an extinct, flightless bird called the little bush moa, shedding light into an unknown corner of avian genetic history. The work is the first complete genetic map of the turkey-sized bird whose distant living cousins include the ostrich, emu, and kiwi.
Published Mechanisms for selective multiple sclerosis treatment strategy
(via sciencedaily.com) Original source Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.
Published 'Cloaked' proteins deliver cancer-killing therapeutics into cells
(via sciencedaily.com) Original source Scientists have designed a way to 'cloak' proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.
Published Scientists uncover a multibillion-year epic written into the chemistry of life
(via sciencedaily.com) Original source Life evolved from simple geochemical processes present on the early Earth. However, the details of this transformation remain a mystery. In this study, researchers modeled the emergence of metabolic pathways from simple geochemical precursors and concluded that surprisingly few reactions in the history of metabolism may have been lost to time.
Published 'The magic of making electricity from metals and air' The vexing carbonate has achieved it!
(via sciencedaily.com) Original source Team develops a high-energy, high-efficiency all-solid-state Na-air battery platform.
Published Genetic mosaicism more common than thought
(via sciencedaily.com) Original source Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.
Published Researchers have unveiled a new method to manipulate cell movement in embryos
(via sciencedaily.com) Original source Scientists have developed a new method that can manipulate the movement of embryonic cells using short-time attractors.
Published How killifish embryos use suspended animation to survive over 8 months of drought
(via sciencedaily.com) Original source The African turquoise killifish lives in ephemeral ponds in Zimbabwe and Mozambique. To survive the annual dry season, the fish's embryos enter a state of extreme suspended animation or 'diapause' for approximately 8 months. Now, researchers have uncovered the mechanisms that enabled the killifish to evolve this extreme survival state.