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Categories: Biology: Cell Biology, Engineering: Biometric
Published Research offers clues for potential widespread HIV cure in people
(via sciencedaily.com) Original source New animal research is helping explain why at least five people have become HIV-free after receiving a stem cell transplant, and may bring scientists closer to developing what they hope will be a widespread cure for the virus that causes AIDS. A new study describes how two nonhuman primates were cured of the monkey form of HIV after receiving a stem cell transplant. It also reveals that two circumstances must co-exist for a cure to occur and documents the order in which HIV is cleared from the body.
Published River erosion can shape fish evolution
(via sciencedaily.com) Original source A new study of the freshwater greenfin darter fish suggests river erosion can be a driver of biodiversity in tectonically inactive regions.
Published How sweet it is: The fruit fly gut influences reproduction by 'tasting' fructose
(via sciencedaily.com) Original source A research group has found that in fruit flies (Drosophila melanogaster), circulating fructose derived from dietary sugar is needed for enhanced egg production after mating. In this species, circulating fructose is required for an increase in germline stem cells, which divide into reproductive cells. This increase leads to enhanced post-mating egg production. These findings may help to determine whether fructose influences the reproduction of mammals, including humans.
Published Researchers successfully induce primate oocytes in the lab
(via sciencedaily.com) Original source The many types of cells in the human body are produced through the process of differentiation, in which stem cells are converted to more specialized types. Currently, it is challenging for researchers to control the differentiation of stem cells in the lab (in vitro). Of particular interest are oocytes, which are female germ cells that develop into eggs. Understanding their development could have far-ranging impacts, from infertility treatment to conservation of endangered species. A new study has successfully induced meiotic (dividing) oocytes from the embryonic stem cells of cynomolgus monkeys, which share many physiological traits with humans. By establishing a culture method for inducing the differentiation of meiotic oocytes, the researchers aimed to shed light on germ cell development in both humans and other primates.
Published The fast and the fibrous: Developing the muscles you need for speed
(via sciencedaily.com) Original source Researchers have identified the role of the large Maf transcription factor family in regulating fast twitch muscle fibers. A mouse model lacking Maf expression in the skeletal muscles exhibited a significant loss of type IIb myofibers, a subtype of fast twitch fibers. Overexpression of large Mafs promoted type IIb muscle fiber induction. The large Maf family may represent potential targets for developing treatments for muscular disorders involving fast twitch fibers.
Published Gene editing tool could help reduce spread of antimicrobial resistance
(via sciencedaily.com) Original source A new tool which could help reduce the spread of antimicrobial resistance is showing early promise, through exploiting a bacterial immune system as a gene editing tool.
Published Deadly virus structures point toward new avenues for vaccine design
(via sciencedaily.com) Original source By comparing the structures of protein complexes from different lineages of the dangerous Lassa virus, a team identified new antibodies and vaccine targets.
Published How tasty is the food?
(via sciencedaily.com) Original source A hormone and specialized brain cells regulate feeding behavior in mice.
Published Failed antibiotic now a game changing weed killer for farmers
(via sciencedaily.com) Original source Weed killers of the future could soon be based on failed antibiotics. Researchers have found a molecule which was initially developed to treat tuberculosis but failed to progress out of the lab as an antibiotic is now showing promise as a powerful foe for weeds that invade our gardens and cost farmers billions of dollars each year.
Published Global macrogenetic map of marine habitat-forming species
(via sciencedaily.com) Original source Species known as marine habitat-forming species -- gorgonians, corals, algae, seaweeds, marine phanerogams, etc.-- are organisms that help generate and structure the underwater landscapes. These are natural refuges for other species, and provide biomass and complexity to the seabeds. But these key species in marine ecosystems are currently threatened by climate change and other perturbations derived from human activity. Now, a study warns that even in the marine protected areas (MPAs) the genetic diversity of structural species is not protected, although it is essential for the response and adaptation of populations to changes that alter the natural environment.
Published Study shows key role for human T cells in the control of Respiratory Syncytial Virus (RSV) infection
(via sciencedaily.com) Original source A new study has shown that human T cells have an important role to play in controlling infection.
Published Where do our limbs come from?
(via sciencedaily.com) Original source Scientists have uncovered new clues about the origin of paired appendages -- a major evolutionary step that remains unresolved and highly debated.
Published Move over, armadillos: There's a new bone-plated mammal in town
(via sciencedaily.com) Original source Armadillos have long been considered to be the only living mammals that produce protective bony plates. But a new study unexpectedly shows that African spiny mice produce the same structures beneath the skin of their tails, which until now had gone largely undetected.
Published A look into the heart of cellular waste disposal
(via sciencedaily.com) Original source Researchers reveal how a nanomachine takes care of cleaning up inside the cell.
Published Engineers create bacteria that can synthesize an unnatural amino acid
(via sciencedaily.com) Original source Researchers have engineered bacteria to synthesize an amino acid that contains a rare functional group that others have shown to have implications in the regulation of our immune system. The researchers also taught a single bacterial strain to create the amino acid and place it at specific sites within target proteins. These findings provide a foundation for developing unique vaccines and immunotherapies in the future.
Published Previous smallpox vaccine provides immunity to mpox
(via sciencedaily.com) Original source Vaccines against smallpox given until the mid-1970s offer continuing cross-reactive immunity to mpox (previously known as monkeypox), researchers report.
Published Researchers find new mechanism for sodium salt detoxification in plants
(via sciencedaily.com) Original source A team of researchers has found a mechanism in thale cress (Arabidopsis thaliana) which enables plants to provide protection against salt stress for their sensitive stem cells in the meristem at the root tip.
Published Study may explain why high-sugar diets can worsen IBD
(via sciencedaily.com) Original source Excess sugar hampers cells that renew the colon's lining in a mouse model of inflammatory bowel disease (IBD), according to a new study that could help get to the bottom of why limiting sugary foods can ease symptoms for patients with IBD.
Published What you count is not necessarily what counts
(via sciencedaily.com) Original source Seawater is full of bacteria, hundreds of thousands live in every liter. But the sheer number of bacteria living in the water does not necessarily mean a lot. More important is how active they are and how quickly they duplicate.
Published A multiomics approach provides insights into flu severity
(via sciencedaily.com) Original source Researchers were able to identify changes in the accessibility (that is, the 'readability') of transposable elements. To do this, the researchers used an approach combining various sets of multiomics data, which characterize and quantify collections of biomolecules in cells or organisms. One was the transcriptome, which consists of all copies of RNA transcribed from DNA in the cell. The other was the epigenome, which is the collection of chemical changes to DNA that modify gene expression. An advantage of this multiomics approach is that they were able to identify families of transposable elements with changes in accessibility, which would have likely been missed by previous approaches.