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Categories: Biology: Cell Biology, Engineering: Biometric

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Introns are perhaps one of our genome's biggest mysteries. They are DNA sequences that interrupt the sensible protein-coding information in your genes, and need to be 'spliced out.'

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Researchers have taken a key step toward closing the silver nanoparticles knowledge gap with a study that indicates the particles' shape and surface chemistry play key roles in how they affect aquatic ecosystems.

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The discovery of how a critical enzyme 'hidden in nature's blueprint' works sheds new light on how cells control key processes in carbon fixation, a process fundamental for life on Earth. The discovery could help engineer climate resilient crops capable of sucking carbon dioxide from the atmosphere more efficiently, helping to produce more food in the process.

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A research team has discovered how carboxysomes, carbon-fixing structures found in some bacteria and algae, work. The breakthrough could help scientists redesign and repurpose the structures to enable plants to convert sunlight into more energy, paving the way for improved photosynthesis efficiency, potentially increasing the global food supply and mitigating global warming.

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A team has developed a vaccine approach that works like a GPS, guiding the immune system through the specific steps to make broadly neutralizing antibodies against HIV.

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Scientists have discovered a new partnership between a marine diatom and a bacterium that can account for a large share of nitrogen fixation in vast regions of the ocean. The newly-discovered bacterial symbiont is closely related to the nitrogen-fixing Rhizobia which live in partnership with many crop plants and may open up new avenues to engineer nitrogen-fixing plants.

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A 'crazy idea' hatched during a walk in the woods and first tested by a high school student is now an innovative research tool used by scientists worldwide to predict neurotransmitters in fruit fly connectomes.

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In a study of a species of African butterfly, researchers have discovered a previously undescribed molecular mechanism of how the sex of an embryo is initially specified.

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Nature has consistently inspired engineering applications. Recently, a group of researchers drew new inspirations from the vascular network and developed a new type of fluidic system named VasFluidics.

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A recent study led to the development of a powerful epigenetic editing technology. The system unlocks the ability to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation. This innovative approach will help to investigate the role of chromatin modifications in many biological processes, and to program desired gene activity responses, which may prove useful in disease settings.

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Adjuvants make vaccines more effective, though one of the best is an expensive extract from the soap bark tree. To lower the cost and avoid the laborious extraction process from bark, synthetic biologists introduced 38 separate genes into yeast to recreate the synthesis of the active molecule, a complex chemical, QS-21, that has a terpene core and numerous sugars. This may be the longest biosynthetic pathway ever inserted into yeast.

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Freshwater bacteria with small genomes frequently undergo prolonged periods of adaptive stagnation. Based on genomic analyses of samples from European lakes, researchers uncovered specific evolutionary strategies that shape these bacteria's lifestyles. Understanding the evolutionary dynamics of aquatic microbial communities is key to safeguarding ecosystem services.

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Tracking individual enzymes during the breakdown of cellulose for biofuel production has revealed how several roadblocks slow this process when using plant material that might otherwise go to waste. The research may lead to new ways to improve the breakdown process and make the non-edible parts of plants and other plant waste, such as forestry residue, a more competitive source of biofuels.

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Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development. The fasting regime reduces the development of liver cancer in mice with pre-existing liver inflammation. The researchers identified two proteins in liver cells that are jointly responsible for the protective effect of fasting. An approved drug can partially mimic this effect.

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A new computational model simulating fruit fly wing development has enabled researchers to identify previously hidden mechanisms behind organ generation. An research team developed a fruit fly model to reverse engineer the mechanisms that generate organ tissue.

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Researchers have found that herpesvirus infection modifies the structure and normal function of the mitochondria in the host cell. The new information will help to understand the interaction between herpesvirus and host cells. Knowledge can be utilized in the development of viral treatments.

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The earliest stages of mammalian embryo development are like an orchestra performance, where everyone must play at the exact right moment and in perfect harmony. New research identifies one of the conductors making sense of the chaos.

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Plants' ability to sense light and temperature, and their ability to adapt to climate change, hinges on free-forming structures in their cells whose function was, until now, a mystery. Researchers have now determined how these structures work on a molecular level, as well as where and how they form.

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In research that may be a step forward toward finding personalized treatments for Tourette disorder, scientists have bred mice that exhibit some of the same behaviors and brain abnormalities seen in humans with the disorder.

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Researchers have developed a new vaccine technology that has been shown in mice to provide protection against a broad range of coronaviruses with potential for future disease outbreaks -- including ones we don't even know about.