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Categories: Biology: Cell Biology, Engineering: Nanotechnology
Published Researchers have cracked the cellular code on protein folding, offering hope for new therapeutic avenues for many diseases
(via sciencedaily.com) Original source While we often think of diseases as caused by foreign bodies -- bacteria or viruses -- there are hundreds of diseases affecting humans that result from errors in cellular production of its proteins. A team of researchers recently leveraged the power of cutting-edge technology, including an innovative technique called glycoproteomics, to unlock the carbohydrate-based code that governs how certain classes of proteins form themselves into the complex shapes necessary to keep us healthy.
Published New study maps ketamine's effects on brain
(via sciencedaily.com) Original source A mouse study found that the drug ketamine can alter the brain's dopamine system, boosting the case for more targeted medical use.
Published New technique efficiently offers insight into gene regulation
(via sciencedaily.com) Original source Researchers have developed a new technique called MAbID. This allows them to simultaneously study different mechanisms of gene regulation, which plays a major role in development and disease. MAbID offers new insights into how these mechanisms work together or against each other.
Published Pathogens use force to breach immune defenses, study finds
(via sciencedaily.com) Original source New research has revealed a previously unknown process through which pathogens are able to defeat a cell's defense mechanisms with physical force. The discovery represents a potential game-changer in the fight against intracellular pathogens, which cause infectious diseases such as tuberculosis, malaria and chlamydia.
Published Scientists navigate uncharted waters in fish immunology research
(via sciencedaily.com) Original source Upon infection or immunization, all jawed vertebrate species generate proteins called antibodies that bind and neutralize pathogens. Strong and long-lasting antibody responses in warm-blooded species such as mammals are produced in secondary lymphoid microstructures (SLMs) among which germinal centers (GCs) are the centerpiece. Despite the apparent absence of GCs or similar SLMs in cold-blooded vertebrates (e.g., fish), these species can mount significant antibody responses that can persist for several months. Thus, for decades, the outstanding question has remained as to how and where antibody responses are generated in species that lack GCs or analogous SLM structures.
Published Unlocking the secret strength of marine mussels
(via sciencedaily.com) Original source How do you create strong, yet quick-release connections between living and non-living tissues? This is a question that continues to puzzle bioengineers who aim to create materials that bond together for advanced biomedical applications. Looking to nature for inspiration, this research zeroed in on the marine mussel byssus, a fibrous holdfast, which these bivalve mollusks use to anchor themselves in seashore habitats.
Published A patch of protection against Zika virus
(via sciencedaily.com) Original source A simple-to-apply, needle-free vaccine patch is being developed to protect people from the potentially deadly mosquito-borne Zika virus.
Published Photonic chip that 'fits together like Lego' opens door to semiconductor industry
(via sciencedaily.com) Original source A new semiconductor architecture integrates traditional electronics with photonic, or light, components could have application in advanced radar, satellites, wireless networks and 6G telecommunications. And it provides a pathway for a local semiconductor industry.
Published Shedding light on the synthesis of sugars before the origin of life
(via sciencedaily.com) Original source Pentoses are essential carbohydrates in the metabolism of modern lifeforms, but their availability on early Earth is unclear since these molecules are unstable. Now, researchers reveal a chemical pathway compatible with early Earth conditions, by which C6 aldonates could have acted as a source of pentoses without the need for enzymes. Their findings provide clues about primitive biochemistry and bring us closer to understanding life's origin.
Published Harvesting more solar energy with supercrystals
(via sciencedaily.com) Original source Hydrogen is a building block for the energy transition. To obtain it with the help of solar energy, researchers have developed new high-performance nanostructures. The material holds a world record for green hydrogen production with sunlight.
Published Control over friction, from small to large scales
(via sciencedaily.com) Original source Friction is hard to predict and control, especially since surfaces that come in contact are rarely perfectly flat. New experiments demonstrate that the amount of friction between two silicon surfaces, even at large scales, is determined by the forming and rupturing of microscopic chemical bonds between them. This makes it possible to control the amount of friction using surface chemistry techniques.
Published Harnessing the power of a parasite that can stop pain
(via sciencedaily.com) Original source For the first time, scientists have begun to figure out why the disfiguring skin lesions caused by cutaneous leishmaniasis don't hurt.
Published The waxy surface protecting plants might hold the key to developing stronger crops
(via sciencedaily.com) Original source Researchers have discovered that the waxy protective barrier around plants might play a role in sending chemical signals to other plants and insects.
Published Armed to the hilt: Study solves mystery behind bacteria's extensive weaponry
(via sciencedaily.com) Original source A new study tackles the mystery of why bacteria often carry diverse ranges of weapons. The findings show that different weapons are best suited to different competition scenarios. Short-range weapons help bacteria to invade established communities; long-range weapons are useful once established.
Published Brittle stars can learn just fine -- even without a brain
(via sciencedaily.com) Original source We humans are fixated on big brains as a proxy for smarts. But headless animals called brittle stars have no brains at all and still manage to learn through experience, new research reveals. These shy marine creatures have no brain to speak of -- just nerve cords running down each of their five wiggly arms. But that seems to be enough to learn by association, researchers report.
Published Fighting fruit flies help researchers understand why we stay angry
(via sciencedaily.com) Original source Researchers are homing in on the neurons, circuits, and mechanisms responsible for persistent aggression in fruit flies.
Published Clever dosage control mechanism of biallelic genes
(via sciencedaily.com) Original source Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.
Published Key protein in blood vessel's growth identified
(via sciencedaily.com) Original source New research identifies the class II PI3K-C2b protein, a member of the PI3 family of kinases, as one of the key regulators of blood vessels growth in humans and other mammals. Mutations in these family of proteins may lead to vascular malformations and the precise understanding of the whole process is instrumental in opening the door to new therapeutic approaches in the future.
Published Researchers decipher enzyme scissors of intestinal microbes
(via sciencedaily.com) Original source Fruit and vegetables contain a variety of plant natural products such as flavonoids, which give fruits their colour and are said to have health-promoting properties. Most plant natural products occur in nature as glycosides, i.e. chemical compounds with sugars. In order for humans to absorb the healthy plant natural products, the sugar must be split off in the intestine. Microorganisms in the intestinal flora help to speed up the process. So-called C-glycosides, i.e. plant natural products with a carbon-based bond to a sugar, would even be practically indigestible without the intestinal microbes (e.g. nothofagin in rooibos tea).
Published Releasing brakes on biocatalysis
(via sciencedaily.com) Original source Enzymes from microorganisms can produce hydrogen (H2) under certain conditions, which makes them potential biocatalysts for biobased H2 technologies. In order to make this hydrogen production efficient, researchers are trying to identify and eliminate possible limiting factors. These include formaldehyde, which occurs naturally as a metabolic product in cells and inhibits the particularly efficient [FeFe] hydrogenase.