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Categories: Biology: Cell Biology, Engineering: Nanotechnology
Published Living in a disadvantaged neighborhood affects food choices, weight gain and the microstructure of the brain
(via sciencedaily.com) Original source A new study finds poor quality of available foods, increased intake of calories from foods high in trans-fatty acids, and environments that do not foster physical activity, all prevalent in disadvantaged neighborhoods, disrupt the flexibility of information processing in the brain that is involved in reward, emotion regulation, and cognition.
Published Genome editing: Reducing off-target mutations in DNA
(via sciencedaily.com) Original source Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded 'nicks' in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.
Published Genetically modified bacteria break down plastics in saltwater
(via sciencedaily.com) Original source Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.
Published Using topology, Researchers advance understanding of how cells organize themselves
(via sciencedaily.com) Original source R esearchers created a machine learning algorithm using computational topology that profiles shapes and spatial patterns in embryos to study how these cells organize themselves into tissue-like architectures. In a new study, they take that system to the next level, opening a path to studying how multiple types of cells assemble themselves.
Published Specialized gut immune cells pinpointed that can limit progression of inflammatory bowel disease
(via sciencedaily.com) Original source Researchers have characterized a specialized type of immune cell, which plays a key role in protecting and repairing the cells in the healthy human gut.
Published Researchers discover tissue-specific protection against protein aggregation
(via sciencedaily.com) Original source Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail. By understanding how different tissues tackle protein build up, this research could accelerate the identification of ways to protect tissues that are vulnerable to protein build up, possibly tackling both disease-associated protein aggregates and also age-dependent aggregates that accelerate the functional decline of tissues.
Published Tiny nanocarriers could prove the magic bullet for acne sufferers
(via sciencedaily.com) It's a skin disorder that makes life miserable for around 800 million teenagers and adults worldwide, but cientists may have found an effective treatment for acne, delivered via tiny nanoparticles.
Published From hagfish to membrane: Modeling age-related macular degeneration
(via sciencedaily.com) Original source Researchers have successfully demonstrated that hagfish slime proteins can accurately replicate membranes in the human eye. Scientists were able to properly grow retinal cells on hagfish slime proteins and prove that the protein's behavior changes as the membrane mimics stages of aging and disease.
Published Flu: Interferon-gamma from T follicular helper cells is required to create lung-resident memory B cells
(via sciencedaily.com) Original source During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity. These long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes and reside there permanently as the first layer of defense that can quickly react to produce antibodies in a future infection.
Published Mysterious family of microbial proteins hijack crops' cellular plumbing
(via sciencedaily.com) Original source Some crop pathogens use a clever trick to multiply and spread infection: they hijack the plant's cellular plumbing. In a new study, researchers unveil a class of bacterial proteins that fold into a straw-like shape and insert themselves into the plant cell membrane, allowing the inside of the leaf to become waterlogged. The researchers also figured out a possible way to block the water channel proteins and prevent infection.
Published A protein on cancer cells supports the immune response against tumors
(via sciencedaily.com) Original source Scientists identify a new and surprising function of a membrane protein on the surface of cancer cells: It supports and stabilizes an important 'co-stimulatory' factor that enhances the activation of T cells, thus improving the immune response against the tumor.
Published Majority rule in complex mixtures
(via sciencedaily.com) The very first life on earth is thought to have developed from 'protocells' -- liquid mixtures of many different types of molecules. Researchers have now shown that in such mixtures, small imbalances in the number of molecules of different types can have an unexpected effect. A surprising interplay with the complex pattern of interactions strongly amplifies such imbalances -- meaning that a type of molecule that is only slightly in the majority can almost entirely separate out from the others. These fundamental findings point towards a new mechanism that will apply in many complex mixtures. For instance, this would be a way for cells to control the formation of structures by fine-tuning the concentration of different molecules.
Published 'Dormant' HIV produces RNA and proteins during anti-retroviral therapy
(via sciencedaily.com) Original source HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have long been thought to be dormant, but two independent groups of researchers report that a subset of these cells spontaneously produce HIV RNA and proteins that may impact patients' HIV-specific immune responses.
Published Pixel-by-pixel analysis yields insights into lithium-ion batteries
(via sciencedaily.com) By mining X-ray images, researchers have made significant new discoveries about the reactivity of lithium iron phosphate, a material used in batteries for electric cars and in other rechargeable batteries.
Published Chemist uses nature as inspiration for a sustainable, affordable adhesive system
(via sciencedaily.com) A chemist drew inspiration from the natural world, from his experiences scuba diving to studying shellfish in his lab. He has developed a sustainable adhesive system -- an alternative to toxic, permanent, traditional adhesives.
Published Freshwater connectivity can transport environmental DNA through the landscape
(via sciencedaily.com) A new article uses environmental DNA (eDNA) metabarcoding to analyze fish and zooplankton communities. The study found that the movement of water between freshwater bodies, or freshwater connectivity, can transport eDNA. This highlights the potential of eDNA to provide a comprehensive view of freshwater biodiversity.
Published Comprehensive insulin signalling map shows interplay between genes and diet
(via sciencedaily.com) Original source Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet.
Published Researchers discover genes behind antibiotic resistance in deadly superbug infections
(via sciencedaily.com) Original source Researchers have uncovered new genetic insights into Staphylococcus aureus, revealing what makes the bacterium so dangerous when it enters the blood.
Published Ultrathin nanotech promises to help tackle antibiotic resistance
(via sciencedaily.com) Researchers have invented a nano-thin superbug-slaying material that could one day be integrated into wound dressings and implants to prevent or heal bacterial infections. The innovation -- which has undergone advanced pre-clinical trials -- is effective against a broad range of drug-resistant bacterial cells, including 'golden staph', which are commonly referred to as superbugs.
Published Both high-protein and normal-protein diets are effective for T2D management
(via sciencedaily.com) Original source New findings indicate that the type of protein in the diet is not as important as the overall amount of weight loss for those with Type 2 diabetes. 106 adults with T2D were randomly assigned to either the high-protein or normal-protein diet for 52 weeks. Both diets were energy-restricted. The high-protein diet included recommendations to include lean beef in the diet, while the normal-protein diet instructed participants to refrain from eating any red meats. The team of researchers found that both a high-protein diet (40 percent of total calories from protein) and a moderate-protein diet (21 percent of total calories from protein) were effective in improving glucose control, weight loss and body composition in people with Type 2 diabetes.