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Categories: Biology: Cell Biology, Engineering: Nanotechnology

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Researchers have devised a tiny, nano-sized sensor capable of detecting protein biomarkers in a sample at single-molecule precision. Fittingly coined as 'hook and bait,' a tiny protein binder fuses to a small hole created in the membrane of a cell -- known as a nanopore ­-- which allows ionic solution to flow through it. When the sensor recognizes a targeted molecule, the ionic flow changes. This change in flow serves as the signal from the sensor that the biomarker has been found.

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Muscle degeneration, the most prevalent cause of frailty in hereditary diseases and aging, could be caused by a deficiency in one key enzyme in a lipid biosynthesis pathway. Researchers now characterize how the enzyme PCYT2 affects muscle health in disease and aging in laboratory mouse models.

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When lymphatic vessels fail, typically their ability to pump out the fluid is compromised. Researchers have now developed a new treatment using nanoparticles that can repair lymphatic vessel pumping. Traditionally, researchers in the field have tried to regrow lymphatic vessels, but repairing the pumping action is a unique approach.

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Researchers have developed biosensor technology that will allow you to operate devices, such as robots and machines, solely through thought control.

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Noise from human activities is harming ocean invertebrates and ecosystems, new research shows.

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It is extremely rare for a new plant species to be discovered in Japan, a nation where flora has been extensively studied and documented. Nevertheless, botanists recently uncovered a stunning new species of orchid whose rosy pink petals bear a striking resemblance to glasswork. Interestingly, it can be found in familiar environments such as lawns and parks, and even in private gardens and on balconies. This research suggests that other new species may be hiding in common places.

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The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell. It also allows the replacement of used cells from a limited number of 'stem' cells, which then proliferate and specialize. In cancer, however, cell proliferation is no longer controlled and becomes chaotic. Researchers have discovered that, in a healthy individual, certain blood immune cells, the monocytes, also have this ability to proliferate, with the aim to replace tissue macrophages, which are essential for the proper functioning of our body.

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A new discovery, reported in a global study that encompassed more than a decade of research, could lead to the breeding of corn crops that can withstand drought and low-nitrogen soil conditions and ultimately ease global food insecurity.

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An international research team produced the first large-scale analysis of more than 400 newly sequenced and existing Omnitrophota genomes, uncovering new details about their biology and behavior.

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It has long been known that viral infections can be more severe in males than females, but the question as to why has remained a mystery -- until possibly now. Researchers have found that female mouse and human Natural Killer cells have an extra copy of an X chromosome-linked gene called UTX. UTX acts as an epigenetic regulator to boost NK cell anti-viral function, while repressing NK cell numbers.

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Decline in the hypothalamic Menin may play a key role in aging, according to a new study. The findings reveal a previously unknown driver of physiological aging, and suggest that supplementation with a simple amino acid may mitigate some age-related changes.

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New research makes it likely that proteins responsible for activating mosquito sperm can be shut down, preventing them from swimming to or fertilizing eggs.

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A cytokinin-mediated, proliferation-based mechanism is involved in the generation and maintenance of cell-type specific tissue boundaries during vascular development in Arabidopsis roots. Specifically, the HANABA-TARANU transcription factor forms a feed-forward loop to cytokinin signaling, which in turn regulates the position and frequency of cell proliferation of proto-vascular cells such that mechanical stress of the surrounding tissues guides growth in an apical-oriented manor, maintaining cell patterning throughout the tissue section.

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The human immunodeficiency virus HIV-1 is able to infect various tissues in humans. Once inside the cells, the virus integrates its genome into the cellular genome and establishes persistent infections. The role of the structure and organization of the host genome in HIV-1 infection is not well understood. Using a cell culture model based on brain immune microglia cells, an international research team has now defined the insertion patterns of HIV-1 in the genome of microglia cells.

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'Miniature shredders' are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study now shows. For example, cancer cells have a special variant that can supply them particularly effectively with building blocks for their energy metabolism.

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The androgen receptor is a key transcriptional factor for the proper sex development -- especially in males -- and the physiological balance of all the tissues that express this receptor. The androgen receptor is involved in several pathologies and syndromes, such as the spinal and bulbar muscular atrophy or androgen insensitivity syndrome, among others, for which there is no specific treatment. Regarded as the main initial and progression factor in prostate cancer -- the second most common malignant disease in men in industrialized countries -- this receptor has been, for decades, the main therapeutical target for the treatment against this disease.

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Pushing the MINFLUX technique to higher spatial and temporal precision allows protein dynamics to be observed under physiological conditions.

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The western chimpanzees of Guinea are threatened by mining activities. Using a novel genetic approach, researchers have collected information on population size and community structure of the endangered species. These data provide an important baseline to assess the impact of mining.

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Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways. A new review highlights six mechanisms by which cells repair DNA damage. By attacking these mechanisms, future applied researchers will be able to trip up cancer's reproduction and growth.

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A new project is using advanced object recognition technology to keep toxin-contaminated wheat kernels out of the food supply and to help researchers make wheat more resistant to fusarium head blight, or scab disease, the crop's top nemesis.