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Categories: Biology: Cell Biology, Physics: General

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A technical achievement marks a significant advance in the burgeoning field of observing individual molecules without the aid of fluorescent labels. While these labels are useful in many applications, they alter molecules in ways that can obscure how they naturally interact with one another. The new label-free method makes the molecules so easy to detect, it is almost as if they had labels.

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Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells.

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Reaserchers have created a prototype for what they call 'living bioelectronics': a combination of living cells, gel, and electronics that can integrate with living tissue. Tests in mice found that the devices could continuously monitor and improve psoriasis-like symptoms, without irritating skin.

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Researchers combined computer simulations and transmission electron microscopy experiments to better understand the ordering mobility and formation of microstructure domains in Fe3Al alloy. They were able to correlate structural changes with heat treatment to understand how particular mechanical behavior can be achieved. This is expected to allow the superelastic properties of Fe3Al to harnessed for the 3D printing of construction materials for absorbing seismic activity.

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Lenses are used to bend and focus light. Normal lenses rely on their curved shape to achieve this effect, but physicists have made a flat lens of only three atoms thick which relies on quantum effects. This type of lens could be used in future augmented reality glasses.

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Research work on symbiosis -- a mutually beneficial relationship between living organisms -- is pushing back against the newer theory of a 'single-origin' of root nodule symbiosis (RNS) -- that all symbiosis between plant root nodules and nitrogen-fixing bacteria stems from one point--instead suggesting a 'multiple-origin' theory of sybiosis which opens a better understanding for genetically engineering crops.

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Researchers recently published findings that could lay the groundwork for applying quantum computing methods to protein structure prediction.

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Researchers have, for the first time, visualized the full network of blood vessels across the cortex of awake mice, finding that blood vessels rhythmically expand and contract leading to 'waves' washing across the surface of the brain. These findings improve the understanding of how the brain receives blood, though the function of the waves remains a mystery.

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Researchers demonstrated a quantum algorithmic speedup with the quantum approximate optimization algorithm, laying the groundwork for advancements in telecommunications, financial modeling, materials science and more.

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Researchers have discovered that the protein hnRNPM prevents the cell from making mistakes while it is producing new proteins, which helps maintain the integrity of this vital process.

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New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix. Clarifying these molecular mechanisms contributes greatly to designing gene-editing tools accurate enough for gene therapy treatments.

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Engineers establish the link between oxygen and graphene quality and present an oxygen-free chemical vapor deposition method (OF-CVD) that can reproducibly create high-quality samples for large-scale production. The graphene they synthesized with their new method proved nearly identical to exfoliated samples and was capable of producing the fractional quantum Hall effect.

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A new method of drug delivery using proline, an amino acid found in chicken feathers and skin tissue, could be used to limit the side effects of chemotherapy and repair important enzymes, new research suggests.

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Hummingbird flight mechanics have been well studied but far less is known about how their sense of touch helps them sip nectar from a flower without bumping into it. Most of what scientists know about how touch is processed in the brain comes from studies on mammals, but bird brains are very different from mammal brains. New research shows that touch and air pressure on the wings and legs activate specific clusters of neurons in two regions of the forebrain to create a map of their body, which may help hummingbirds make nuanced adjustments to flight.

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Newly generated, complete genomes for the sex chromosomes of six primate species may inform conservation of these endangered species and shed light on sex-related genetic diseases in both humans and our closest living relatives.

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Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides difficile, a common and dangerous hospital-associated bacterial infection, and was effective against more than 130 multidrug-resistant bacterial strains in cell culture.

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A new perspectives article focuses on different ways to study the mouthfeel of food using atomic force microscopy to better understand the biophysical mechanisms that contribute to taste sensations in a broader sense. New findings in this area could drive the development of health-promoting products that contain less salt, fat, sugar and calories but still have a convincing mouthfeel.

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The benefits gained with higher lifestyle scores may be associated with the positive influence of heart disease risk factors on the aging of the body and its cells, finds a new study in the Journal of the American Heart Association

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Researchers have managed to generate propagating spin waves at the nanoscale and discovered a novel pathway to modulate and amplify them. Their discovery could pave the way for the development of dissipation free quantum information technologies. As the spin waves do not involve electric currents these chips will be free from associated losses of energy. The rapidly growing popularity of artificial intelligence comes with an increasing desire for fast and energy efficient computing devices and calls for novel ways to store and process information. The electric currents in conventional devices suffer from losses of energy and subsequent heating of the environment.

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Review of research to-date suggests vaccination remains the most effective strategy for avian influenza prevention and control in humans, despite varying vaccine efficacy across strains.