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Categories: Biology: Cell Biology, Mathematics: Puzzles
Published Photosynthetic mechanism of purple sulfur bacterium adapted to low-calcium environments
(via sciencedaily.com) Original source Purple sulfur bacteria (PSB) convert light energy into chemical energy through photosynthesis. Interestingly, certain species can photosynthesize even in environments with low-calcium levels. Using cryo-electron microscopy, researchers unveiled the structure of light-harvesting complexes and elucidated the mechanism that facilitates photosynthesis under low-calcium conditions.
Published Breakthrough in developing the PD-1-enhanced DNA vaccine for over 6-year cART-free AIDS prevention and virologic control
(via sciencedaily.com) Original source Researchers found that PD-1-enhanced DNA vaccination can induce sustained virus-specific CD8+ T cell immunity in an AIDS monkey model. The vaccinated monkeys remained free of AIDS for six years and achieved virologic control without the need for combination antiretroviral therapy (cART), a treatment used to suppress viral replication in individuals living with human immunodeficiency virus (HIV). The study also found that polyfunctional and broadly reactive effector-memory virus-specific T cells were maintained in the protected experimental macaques for over six years. The findings provide supporting evidence that the PD-1-enhanced DNA vaccine strategy holds promise as a third-generation DNA vaccine for AIDS prevention and immunotherapy.
Published Researchers are using RNA in a new approach to fight HIV
(via sciencedaily.com) Original source A pharmacy associate professor has developed a novel nanomedicine loaded with genetic material called small interfering RNAs (siRNA) to fight human immunodeficiency virus (HIV) using gene therapy.
Published Using metabolomics for assessing safety of chemicals may reduce the use of lab rats
(via sciencedaily.com) Original source Scientists have discovered a more robust way of grouping chemicals and using read-across for toxicological data to meet regulatory requirements, which could greatly reduce animal testing.
Published It's the spin that makes the difference
(via sciencedaily.com) Original source Biomolecules such as amino acids and sugars occur in two mirror-image forms -- in all living organisms, however, only one is ever found. Why this is the case is still unclear. Researchers have now found evidence that the interplay between electric and magnetic fields could be at the origin of this phenomenon.
Published New model identifies drugs that shouldn't be taken together
(via sciencedaily.com) Original source Researchers have developed a multipronged strategy to identify the transporters used by different drugs. Their approach, which makes use of both tissue models and machine-learning algorithms, has already revealed that a commonly prescribed antibiotic and a blood-thinner can interfere with each other.
Published Study reveals molecular mechanisms behind hibernation in mammals
(via sciencedaily.com) Original source Researchers have characterized changes in the structure of motor proteins, called myosins, and energy consumption that occur during hibernation, highlighting key differences in large and small hibernators.
Published Scientists develop novel radiotracer for earlier detection of disease
(via sciencedaily.com) Original source Scientists have developed a new radiotracer (called [18F]4-FDF) that can map how cells use fructose for energy.
Published Fresh meat: New biosensor accurately and efficiently determines meat freshness
(via sciencedaily.com) Original source Despite the technological advances keeping meat fresh for as long as possible, certain aging processes are unavoidable. Adenosine triphosphate is a molecule produced by breathing and responsible for providing energy to cells. When an animal stops breathing, ATP synthesis also stops, and the existing molecules decompose into acid, diminishing first flavor and then safety. Hypoxanthine and xanthine are intermediate steps in this transition. Assessing their prevalence in meat indicates its freshness.
Published Bat 'nightclubs' may be the key to solving the next pandemic
(via sciencedaily.com) Original source Researchers are studying how bats can carry deadly viruses, but not develop symptoms. They found that what happens during swarming behavior -- like social gatherings for bats -- may hold the key to understanding their viral tolerance and translate to human health in fighting off diseases like Ebola and COVID-19.
Published Eating too much protein is bad for your arteries, and this amino acid is to blame
(via sciencedaily.com) Original source Consuming over 22% of dietary calories from protein can lead to increased activation of immune cells that play a role in atherosclerotic plaque formation and drive the disease risk, new study showed.
Published Viruses that can help 'dial up' carbon capture in the sea
(via sciencedaily.com) Original source Armed with a catalog of hundreds of thousands of DNA and RNA virus species in the world's oceans, scientists are now zeroing in on the viruses most likely to combat climate change by helping trap carbon dioxide in seawater or, using similar techniques, different viruses that may prevent methane's escape from thawing Arctic soil.
Published Link between high levels of niacin -- a common B vitamin -- and heart disease, study suggests
(via sciencedaily.com) Original source Researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol. The team discovered a link between 4PY, a breakdown product from excess niacin, and heart disease. Higher circulating levels of 4PY were strongly associated with development of heart attack, stroke and other adverse cardiac events in large-scale clinical studies. The researchers also showed in preclinical studies that 4PY directly triggers vascular inflammation which damages blood vessels and can lead to atherosclerosis over time.
Published Toxoplasmosis: Evolution of infection machinery
(via sciencedaily.com) Original source Researchers have identified a protein that evolved concurrently with the emergence of cellular compartments crucial for the multiplication of the toxoplasmosis pathogen.
Published Superbug killer: New synthetic molecule highly effective against drug-resistant bacteria
(via sciencedaily.com) Original source A new antibiotic overcomes antimicrobial resistance mechanisms that have rendered many modern drugs ineffective and are driving a global public health crisis.
Published Big new idea introduced with the help of tiny plankton
(via sciencedaily.com) Original source A new model bridges the rules of life at the individual scale and the ecosystem level, which could open new avenues of exploration in ecology, global change biology, and ultimately ecosystem management.
Published Do sugar-free candy and gum give you gas? Researchers think they know why
(via sciencedaily.com) Original source Scientists may have figured out why some people have trouble digesting sorbitol, a sugar alcohol used in sugar-free gum, mints, candy and other products.
Published Asexual propagation of crop plants gets closer
(via sciencedaily.com) Original source When the female gametes in plants become fertilized, a signal from the sperm activates cell division, leading to the formation of new plant seeds. This activation can also be deliberately triggered without fertilization, as researchers have shown. Their findings open up new avenues for the asexual propagation of crop plants.
Published Protein-rich breakfast boosts satiety and concentration
(via sciencedaily.com) Original source A new study has explored the link between diet and cognitive function, and the results reveal that a protein-rich breakfast can increase satiety and improve concentration. This is important knowledge in a society with increasing obesity rates and lifestyle-related diseases.
Published Root microbes may be the secret to a better tasting cup of tea
(via sciencedaily.com) Original source You'd think the complex flavor in a quality cup of tea would depend mainly on the tea varieties used to make it. But a new study shows that the making of a delicious cup of tea depends on another key ingredient: the collection of microbes found on tea roots. By altering that assemblage, the authors showed that they could make good-quality tea even better.