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Categories: Biology: Cell Biology, Ecology: Research
Published Nanoplastics and 'forever chemicals' disrupt molecular structures, functionality
(via sciencedaily.com) Original source Researchers have made significant inroads in understanding how nanoplastics and per- and polyfluoroalkyl substances (PFAS) -- commonly known as forever chemicals -- disrupt biomolecular structure and function. The work shows that the compounds can alter proteins found in human breast milk and infant formulas -- potentially causing developmental issues downstream.
Published Mapping the world's fungi from air samples
(via sciencedaily.com) Original source Researchers have found that the key to a quick and cost-effective mapping of biodiversity has been right in front of our eyes all along, but at the same time invisible -- i.e., in the air that surrounds us.
Published Opening the right doors: 'Jumping gene' control mechanisms revealed
(via sciencedaily.com) Original source International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents the transcription of 'jumping genes.' DDM1 makes 'jumping genes' more accessible for transcription-suppressing chemical marks to be deposited. Because a variant of this protein exists in humans, the discovery provides insight into genetic conditions caused by such 'jumping gene' mutations.
Published First ever 3D reconstruction of 52,000-year-old woolly mammoth chromosomes thanks to serendipitously freeze-dried skin
(via sciencedaily.com) Original source An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample. The fossilized chromosomes, which are around a million times longer than most ancient DNA fragments, provide insight into how the mammoth's genome was organized within its living cells and which genes were active within the skin tissue from which the DNA was extracted. This unprecedented level of structural detail was retained because the mammoth underwent freeze-drying shortly after it died, which meant that its DNA was preserved in a glass-like state.
Published Researchers pinpoint brain cells that delay first bite of food
(via sciencedaily.com) Original source Do you grab a fork and take a first bite of cake, or say no and walk away? Our motivation to eat is driven by a complex web of cells in the brain that use signals from within the body, as well as sensory information about the food in front of us, to determine our behaviors. Now, scientists have identified a group of neurons in a small and understudied region of the brain -- the parasubthalamic nucleus (PSTN) -- that controls when an animal decides to take a first bite of food.
Published Novel genome editing approach restores hearing in adult preclinical models with genetic deafness
(via sciencedaily.com) Original source Researchers restored hearing in preclinical mouse models with a specific form of inherited deafness called DFNA50 caused by mutations in microRNA, by using a novel in vivo CRISPR genome editing approach. Since mouse and human microRNAs have identical sequences, the researchers hope this work can one day be translated into applications for humans.
Published Atlas of proteins reveals inner workings of cells
(via sciencedaily.com) Original source Researchers discover how proteins behave inside cells using AI, which has the potential to guide drug design.
Published Discovery of a new defense mechanism in bacteria
(via sciencedaily.com) Original source When confronted with an antibiotic, toxic substance, or other source of considerable stress, bacteria are able to activate a defense mechanism using cell-to-cell communication to 'warn' unaffected bacteria, which can then anticipate, shield themselves and spread the warning signal.
Published Not so simple: Mosses and ferns offer new hope for crop protection
(via sciencedaily.com) Original source Mosses, liverworts, ferns and algae may offer an exciting new research frontier in the global challenge of protecting crops from the threat of disease.
Published The detection of a massive harmful algal bloom in the Arctic prompts real-time advisories to western Alaskan communities
(via sciencedaily.com) Original source A summer 2022 research cruise that detected a massive and highly toxic harmful algal bloom (HAB) in the Bering Strait has provided a dramatic example of science that utilized new technology to track a neurotoxic HAB and effectively communicate that information in real-time to protect remote communities in coastal Alaska.
Published Phage-derived enzyme targets E. faecalis biofilms to mitigate acute graft-versus-host disease
(via sciencedaily.com) Original source Acute graft-versus-host disease occurs when donor immune cells attack the recipient's tissues after an allogeneic hematopoietic stem cell transplantation (allo-HCT). Researchers recently identified a bacteriophage-derived enzyme called endolysin capable of targeting biofilms formed by Enterococcus faecalis. Their findings offer hope for tailored interventions in allo-HCT.
Published Discovery could help reduce adverse side effects of popular next-generation obesity medications
(via sciencedaily.com) Original source By teasing apart the therapeutic benefits from the adverse effects of new generation obesity medications, researchers found a population of neurons in the brain that controls food intake without causing nausea in an animal model.
Published Big gain in battle against harmful bacteria
(via sciencedaily.com) Original source An unexpected find has enabled important progress to be made in the battle against harmful bacteria.
Published The plague may have caused the downfall of the Stone Age farmers
(via sciencedaily.com) Original source Ancient DNA from bones and teeth hints at a role of the plague in Stone Age population collapse. Contrary to previous beliefs, the plague may have diminished Europe's populations long before the major plague outbreaks of the Middle Ages, new research shows.
Published New one-step method to make multiple edits to a cell's genome
(via sciencedaily.com) Original source A team of scientists have developed a new method that enables them to make precise edits in multiple locations within a cell -- all at once. Using molecules called retrons, they created a tool that can efficiently modify DNA in bacteria, yeast, and human cells.
Published Global database reveals large gaps in our knowledge of four-footed animals
(via sciencedaily.com) Original source Researchers developed TetrapodTraits -- a global database of animals with four feet -- which can now be applied for better ecology, evolution and conservation research.
Published Whale remains tracked to highlight sustainable disposal benefits
(via sciencedaily.com) Original source A new study highlights the sustainable, cultural and ecosystem benefits of offshore removal or decomposition of whale remains. The study tracked the remains of a humpback whale that was intercepted before washing up on the shoreline, then repositioned 30km offshore and fitted with a satellite tag that tracked its position as it drifted with the wind and currents for 6 days before falling to the seabed.
Published How a plant app helps identify the consequences of climate change
(via sciencedaily.com) Original source A research team has developed an algorithm that analyses observational data from a plant identification app. The novel approach can be used to derive ecological patterns that could provide valuable information about the effects of climate change on plants.
Published 'Sacrifice' of virus data clears the path to open a disease discovery pipeline
(via sciencedaily.com) Original source Tens of millions of still-unknown or misunderstood viruses can cause diseases -- including new pandemics -- and affect the health of valuable terrestrial and marine environments. Now a new pipeline to investigate the 'virosphere,' or all the genomes of viruses and bacteriophages (viruses that attack bacteria) of the world, has been developed by an international collaboration.
Published Cracking open a tasty menu for captive marsupials to sink their teeth into
(via sciencedaily.com) Original source From sifting through topsoil for native truffles to cracking open hard shells of seeds and nuts to munch on the tasty kernels, Australia bettongs and potoroos are described as 'ecosystem engineers' in a two-way relationship between their rich diet and environmental health. However, with native ecosystems and potoroid marsupial numbers in decline, ecology and evolution experts are working to understand how difficult it is to bite into the foods these leading foragers seek out.