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Categories: Biology: Cell Biology, Ecology: Nature

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Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the first time a molecular complex -- called CTF18-RFC in humans and Ctf18-RFC in yeast -- that loads a 'clamp' onto DNA to keep parts of the replication machinery from falling off the DNA strand.

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Highly localized TB strains are less infectious in cosmopolitan cities and more likely to infect people from the geographic area that is the strain's natural habitat. The research provides the first controlled evidence that TB strains may evolve with their human hosts, adapting to be more infectious to specific populations. The findings offer new clues for tailoring preventive treatments after exposure to TB based on affinity between strains host populations.

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Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can differentiate between functional and faulty viral vectors at the single-particle level. This convenient and inexpensive technique will hopefully get us one step closer to advancing treatments for genetic disorders.

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Scientists uncover a pivotal enzyme, XccOpgD, and its critical role in synthesizing C G16, a key compound used by Xanthomonas pathogens to enhance their virulence against plants. This breakthrough opens new avenues for developing targeted pesticides that combat plant diseases without harming beneficial organisms. Insights into XccOpgD's enzymatic mechanism and optimal conditions offer promising prospects for sustainable agriculture, bolstering crop resilience and global food security while minimizing environmental impact.

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Companies and institutes are currently working on biotechnological processes for the production of 'dairy products' without the use of cows: In so-called precision fermentation, egg and milk proteins are produced with the help of bacteria, yeasts or other fungi. This results in foods such as milk or cheese with a familiar flavor and texture. Supporters hope that this will lead to more sustainable food production, as nutrient-rich proteins can be produced using fewer resources. But will consumers accept such products?

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Researchers transferred genes from simple organisms capable of regenerating their bodies into common fruit flies, more complex animals that cannot. They found the transferred gene suppressed an age-related intestinal issue in the flies. Their results suggest studying genes specific to animals with high regenerative capability may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.

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Hotter conditions prevent two tiny organisms working together for mutual benefit, new research shows.

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A clinical trial suggests that a subset of older adults with a genetic predisposition to Alzheimer's disease may benefit from fish oil supplements.

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Study finds that the mass extinction caused by an asteroid about 66 million years ago led to critical changes in bird genomes that ultimately sparked the incredibly diversity living birds.

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An international research team has succeeded in developing a new version of RNA building blocks with higher chemical reactivity and photosensitivity. This can significantly reduce the production time of RNA chips used in biotechnological and medical research. The chemical synthesis of these chips is now twice as fast and seven times more efficient.

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New research led proposes a plan to safeguard Earth's imperiled biodiversity by cryogenically preserving biological material on the moon. The moon's permanently shadowed craters are cold enough for cryogenic preservation without the need for electricity or liquid nitrogen.

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In one of the largest studies of cancer susceptibility across bird species, researchers describe an intriguing relationship between reproductive rates and cancer susceptibility.

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Researchers create the first national glycemic index database, revealing how common foods impact health and contribute to chronic diseases.

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Researchers investigate the representation of native fauna on 4,541 banknotes from 207 countries between 1980 and 2017, to identify geographic hotspots and taxonomic patterns, and determine whether threatened and endemic species were more readily represented.

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Researchers and community scientists monitored urban milkweed plants for butterfly eggs to learn what makes these city gardens more hospitable to monarchs. They found that even tiny city gardens attracted monarchs and became a home to caterpillars.

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In a hopeful sign for demand for more safe, effective antibiotics for humans, researchers have leveraged artificial intelligence to develop a new drug that already is showing promise in animal trials.

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Researchers have succeeded in identifying and synthesizing a group of molecules that can act against the cause of tuberculosis in a new way. They describe that the so-called callyaerins act against the infectious disease by employing a fundamentally different mechanism compared to antibiotic agents used to date.

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Scientists uncover 'striking' immune cell populations poised to fight SARS-CoV-2 in upper airway.

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The NMDAR is involved in numerous cognitive functions including memory. Its movements are tightly coordinated like a choreographed dance routine. Scientists have now figured out how the protein performs a difficult 'Twist'-like dance move. The discovery could lead to new drug compounds that bind to NMDAR more effectively.

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Using powerful new visualization technologies, researchers have captured the first 3-D images of the structure of a key muscle receptor, providing new insights on how muscles develop across the animal kingdom and setting the stage for possible future treatments for muscular disorders.