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Categories: Biology: Cell Biology, Environmental: Wildfires
Published A combination of approved drugs enhances the delivery of anti-bacterial medications to treat tuberculosis
(via sciencedaily.com) Original source Researchers have found that approved drugs that were originally shown to normalize blood vessels surrounding tumors (to improve drug delivery to cancer cells) can enhance the delivery of anti-microbial medications to kill tuberculosis bacteria residing in the lungs.
Published Scientists extract genetic secrets from 4,000-year-old teeth to illuminate the impact of changing human diets over the centuries
(via sciencedaily.com) Original source Researchers have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.
Published New technique for predicting protein dynamics may prove big breakthrough for drug discovery
(via sciencedaily.com) Original source Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them. To that end, a team of researchers has developed a way of using machine learning to rapidly predict multiple protein configurations to advance understanding of protein dynamics and functions.
Published New enzymatic cocktail can kill tuberculosis-causing mycobacteria
(via sciencedaily.com) Original source An enzymatic cocktail can kill a variety of mycobacterial species of bacteria, including those that cause tuberculosis.
Published Milk on ice: Antarctic time capsule of whole milk powder sheds light on the enduring qualities--and evolution--of dairy products past and present
(via sciencedaily.com) Original source In a remarkable discovery, whole milk powder manufactured in New Zealand in 1907 and transported to Antarctica with explorers seeking the South Pole was unveiled after more than a century. The find has allowed dairy researchers to answer the question: Is the milk we enjoy today different from the milk consumed in previous generations? Now, a new comparative study has peered back in time to demonstrate that -- despite advancements in selective breeding and changes to farm practices -- milk of the past and milk today share more similarities than differences and are still crucial building blocks of human nutrition.
Published Old immune systems revitalized in mouse study, improving vaccine response
(via sciencedaily.com) Original source Those with aging immune systems struggle to fight off novel viruses and respond weakly to vaccination. Researchers were able to revitalize the immune system in mice.
Published Super permeable wearable electronics developed for stable, long-term biosignal monitoring
(via sciencedaily.com) Original source Super wearable electronics that are lightweight, stretchable and increase sweat permeability by 400-fold have been developed by scientists, enabling reliable long-term monitoring of biosignals for biomedical devices.
Published New testing approach improves detection of rare but emerging Powassan virus spread by deer ticks
(via sciencedaily.com) Original source Researchers have come up with a new, more accurate method for detecting in ticks the emerging Powassan virus, which can cause life-threatening neuroinvasive disease, including encephalitis and meningitis.
Published Researchers show that introduced tardigrade proteins can slow metabolism in human cells
(via sciencedaily.com) Original source Tardigrade proteins are potential candidates in technologies centered on slowing the aging process and in long-term storage of human cells.
Published Discovery of amino acid unveils how light makes plants open
(via sciencedaily.com) Original source Scientists have uncovered a unique mechanism that regulates the opening of stomata in plants. Phosphorylation of the amino acid Thr881 on the plasma membrane proton pump plays a key role in this process. The study paves the way for the targeted manipulation of plant physiology, with potential applications in agriculture and environmental sustainability.
Published Novel electrochemical sensor detects dangerous bacteria
(via sciencedaily.com) Original source Researchers have developed a novel sensor for the detection of bacteria. It is based on a chip with an innovative surface coating. This ensures that only very specific microorganisms adhere to the sensor -- such as certain pathogens. The larger the number of organisms, the stronger the electric signal generated by the chip. In this way, the sensor is able not only to detect dangerous bacteria with a high level of sensitivity but also to determine their concentration.
Published GPT-4 for identifying cell types in single cells matches and sometimes outperforms expert methods
(via sciencedaily.com) Original source GPT-4 can accurately interpret types of cells important for the analysis of single-cell RNA sequencing -- a sequencing process fundamental to interpreting cell types -- with high consistency compared to that of time-consuming manual annotation by human experts of gene information.
Published Breakthrough antibiotic shows promise against obstinate mycobacterial infections
(via sciencedaily.com) Original source A team of scientists has developed a novel antibiotic named COE-PNH2 that is capable of combating hard-to-treat mycobacterial lung infections. Such infections, which are notorious for resisting conventional treatment, pose a serious health threat, especially to the elderly and those with underlying conditions.
Published Humans pass more viruses to other animals than we catch from them
(via sciencedaily.com) Original source Humans pass on more viruses to domestic and wild animals than we catch from them, according to a major new analysis of viral genomes.
Published Unintended consequences of fire suppression
(via sciencedaily.com) Original source A new study reveals how fire suppression ensures that wildfires will burn under extreme conditions at high severity, exacerbating the impacts of climate change and fuel accumulation.
Published Researchers discover evolutionary 'tipping point' in fungi
(via sciencedaily.com) Original source Scientists have found a 'tipping point' in the evolution of fungi that throttles their growth and sculpts their shapes. The findings demonstrate how small changes in environmental factors can lead to huge changes in evolutionary outcomes.
Published Natural recycling at the origin of life
(via sciencedaily.com) Original source How was complex life able to develop on the inhospitable early Earth? At the beginning there must have been ribonucleic acid (RNA) to carry the first genetic information. To build up complexity in their sequences, these biomolecules need to release water. On the early Earth, which was largely covered in seawater, that was not so easy to do.
Published Scientists close in on TB blood test which could detect millions of silent spreaders
(via sciencedaily.com) Original source Millions of people are spreading tuberculosis unknowingly - now scientists say they are close to developing a new test that is as simple as the lateral flows used during the Covid pandemic.
Published Signs of life would be detectable in single ice grain emitted from extraterrestrial moons
(via sciencedaily.com) Original source Could life be found in frozen sea spray from moons orbiting Saturn or Jupiter? New research finds that life can be detected in a single ice grain containing one bacterial cell or portions of a cell. The results suggest that if life similar to that on Earth exists on these planetary bodies, that this life should be detectable by instruments launching in the fall.
Published As we age, our cells are less likely to express longer genes
(via sciencedaily.com) Original source Aging may be less about specific 'aging genes' and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers. A decline in the expression of long genes with age has been observed in a wide range of animals, from worms to humans, in various human cell and tissue types, and also in individuals with neurodegenerative disease. Mouse experiments show that the phenomenon can be mitigated via known anti-aging factors, including dietary restriction.