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Categories: Biology: Cell Biology, Geoscience: Earthquakes

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Researchers are homing in on the neurons, circuits, and mechanisms responsible for persistent aggression in fruit flies. 

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Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.

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New research identifies the class II PI3K-C2b protein, a member of the PI3 family of kinases, as one of the key regulators of blood vessels growth in humans and other mammals. Mutations in these family of proteins may lead to vascular malformations and the precise understanding of the whole process is instrumental in opening the door to new therapeutic approaches in the future.

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Fruit and vegetables contain a variety of plant natural products such as flavonoids, which give fruits their colour and are said to have health-promoting properties. Most plant natural products occur in nature as glycosides, i.e. chemical compounds with sugars. In order for humans to absorb the healthy plant natural products, the sugar must be split off in the intestine. Microorganisms in the intestinal flora help to speed up the process. So-called C-glycosides, i.e. plant natural products with a carbon-based bond to a sugar, would even be practically indigestible without the intestinal microbes (e.g. nothofagin in rooibos tea).

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Enzymes from microorganisms can produce hydrogen (H2) under certain conditions, which makes them potential biocatalysts for biobased H2 technologies. In order to make this hydrogen production efficient, researchers are trying to identify and eliminate possible limiting factors. These include formaldehyde, which occurs naturally as a metabolic product in cells and inhibits the particularly efficient [FeFe] hydrogenase.

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Bees, wasps and ants belong to the Hymenoptera order and inject a whole cocktail of venomous ingredients when they sting. Despite their tremendous ecological and economic importance, little was previously known about the origins of their venom. Through extensive genomic studies, a team of researchers has now discovered that typical venomous components were already present in the earliest ancestors of Hymenoptera and must therefore have evolved before the stingers of bees and other insects. What's more, and contrary to previous assumptions, the gene for the venom melittin is found solely in bees.

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The evolution of higher cognitive functions in humans has so far mostly been linked to the expansion of the neocortex. Researchers are increasingly realizing, however, that the 'little brain' or cerebellum also expanded during evolution and probably contributes to the capacities unique to humans. A research team has now generated comprehensive genetic maps of the development of cells in the cerebella of human, mouse and opossum. Comparisons of these maps reveal both ancestral and species-specific cellular and molecular characteristics of cerebellum development.

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One in 200 newborns is admitted to a neonatal unit with sepsis caused by a bacteria commonly carried by their mothers -- much greater than the previous estimate, say researchers. The team has developed an ultra-sensitive test capable of better detecting the bacteria, as it is missed in the vast majority of cases.

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Researchers have revealed how amphibians and mammals heal musculoskeletal tissues. Using mechanical testing and microscopy, they found that newts heal their tendons using collagenous tissue that acts as a bridge between damaged areas and possesses structure and functions similar to their native tendon. Their findings suggest that newts will serve as a useful model to study tendon regeneration. 

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A new study found that alcohol consumption may have counteractive effects on CVD risk, depending on the biological presence of certain circulating metabolites -- molecules that are produced during or after a substance is metabolized and studied as biomarkers of many diseases. The researchers observed a total of 60 alcohol consumption-related metabolites, identifying seven circulating metabolites that link long-term moderate alcohol consumption with an increased risk of CVD, and three circulating metabolites that link this same drinking pattern with a lower risk of CVD.

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Extracellular vesicles were found to inhibit the viral infection of COVID-19 and potentially other infectious diseases.

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Researchers have developed a way of joining up the head and tail of a protein, making it more stable and easier to get into cells.

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Researchers characterize nearly 600 microbial genomes collected from goldmine. The study illuminates 'microbial dark matter' residing below the surface. Microbes divide into two groups: minimalists that have one, specialized job or maximalists that are prepared to use any available resource. Study has implications for how underground activities, like mining and carbon storage, could affect or be affected by microbial life. The lifestyle of these 'intraterrestrial' microbes also provides hints to what organisms could be living on other planets.

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Scientists describe how they identified a molecule that may trigger over-consumption of comfort foods after a threatening event.

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Researchers have analyzed the antibody Immunoglobulin M in rainbow trout to shed some light on why these proteins may have evolved over time.

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A new study suggests that E. coli bacteria may have a higher capability to evolve antibiotic resistance than previously believed. Researchers mapped possible mutations in an essential E. coli protein involved in antibiotic resistance and found that 75% of evolutionary paths led to high antibiotic resistance, challenging existing theories about fitness landscapes in evolutionary biology. This discovery may have broader implications for understanding adaptation and evolution in various fields.

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Scientists show for the first time that bacteria can cause itch by activating nerve cells in the skin. The findings can inform new therapies to treat itch that occurs in inflammatory skin conditions like eczema and dermatitis.

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Researchers create transistors combining silicon with biological silk, using common microprocessor manufacturing methods. The silk protein can be easily modified with other chemical and biological molecules to change its properties, leading to circuits that respond to biology and the environment.

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Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a new study.

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Quinoa and many other extremely resilient plants are covered with strange balloon-like 'bladders' that for 127 years were believed to be responsible for protecting them from drought and salt. Research results reveal this not to be the case. These so-called bladder cells serve a completely different though important function. The finding makes it likely that even more resilient quinoa plants will now be able to be bred, which could lead to the much wider cultivation of this sustainable crop worldwide.