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Categories: Biology: Cell Biology, Geoscience: Earthquakes
Published From hagfish to membrane: Modeling age-related macular degeneration
(via sciencedaily.com) Original source Researchers have successfully demonstrated that hagfish slime proteins can accurately replicate membranes in the human eye. Scientists were able to properly grow retinal cells on hagfish slime proteins and prove that the protein's behavior changes as the membrane mimics stages of aging and disease.
Published Flu: Interferon-gamma from T follicular helper cells is required to create lung-resident memory B cells
(via sciencedaily.com) Original source During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity. These long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes and reside there permanently as the first layer of defense that can quickly react to produce antibodies in a future infection.
Published Mysterious family of microbial proteins hijack crops' cellular plumbing
(via sciencedaily.com) Original source Some crop pathogens use a clever trick to multiply and spread infection: they hijack the plant's cellular plumbing. In a new study, researchers unveil a class of bacterial proteins that fold into a straw-like shape and insert themselves into the plant cell membrane, allowing the inside of the leaf to become waterlogged. The researchers also figured out a possible way to block the water channel proteins and prevent infection.
Published A protein on cancer cells supports the immune response against tumors
(via sciencedaily.com) Original source Scientists identify a new and surprising function of a membrane protein on the surface of cancer cells: It supports and stabilizes an important 'co-stimulatory' factor that enhances the activation of T cells, thus improving the immune response against the tumor.
Published Majority rule in complex mixtures
(via sciencedaily.com) The very first life on earth is thought to have developed from 'protocells' -- liquid mixtures of many different types of molecules. Researchers have now shown that in such mixtures, small imbalances in the number of molecules of different types can have an unexpected effect. A surprising interplay with the complex pattern of interactions strongly amplifies such imbalances -- meaning that a type of molecule that is only slightly in the majority can almost entirely separate out from the others. These fundamental findings point towards a new mechanism that will apply in many complex mixtures. For instance, this would be a way for cells to control the formation of structures by fine-tuning the concentration of different molecules.
Published 'Dormant' HIV produces RNA and proteins during anti-retroviral therapy
(via sciencedaily.com) Original source HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have long been thought to be dormant, but two independent groups of researchers report that a subset of these cells spontaneously produce HIV RNA and proteins that may impact patients' HIV-specific immune responses.
Published Chemist uses nature as inspiration for a sustainable, affordable adhesive system
(via sciencedaily.com) A chemist drew inspiration from the natural world, from his experiences scuba diving to studying shellfish in his lab. He has developed a sustainable adhesive system -- an alternative to toxic, permanent, traditional adhesives.
Published Freshwater connectivity can transport environmental DNA through the landscape
(via sciencedaily.com) A new article uses environmental DNA (eDNA) metabarcoding to analyze fish and zooplankton communities. The study found that the movement of water between freshwater bodies, or freshwater connectivity, can transport eDNA. This highlights the potential of eDNA to provide a comprehensive view of freshwater biodiversity.
Published Largest historic fire death toll belongs to aftermath of 1923 Japan Earthquake
(via sciencedaily.com) Original source Fires that raged in the days following the 1 September 1923 magnitude 7.9 Kant earthquake killed roughly 90% of the 105,000 people who perished in and around Tokyo, making it one of the deadliest natural disasters in history -- comparable to the number of people killed in the World War II atomic bombing of Hiroshima. The story of the conflagration, not well-known outside of Japan, holds important lessons for earthquake scientists, emergency response teams and city planners, according to a new article.
Published Comprehensive insulin signalling map shows interplay between genes and diet
(via sciencedaily.com) Original source Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet.
Published Researchers discover genes behind antibiotic resistance in deadly superbug infections
(via sciencedaily.com) Original source Researchers have uncovered new genetic insights into Staphylococcus aureus, revealing what makes the bacterium so dangerous when it enters the blood.
Published Ultrathin nanotech promises to help tackle antibiotic resistance
(via sciencedaily.com) Researchers have invented a nano-thin superbug-slaying material that could one day be integrated into wound dressings and implants to prevent or heal bacterial infections. The innovation -- which has undergone advanced pre-clinical trials -- is effective against a broad range of drug-resistant bacterial cells, including 'golden staph', which are commonly referred to as superbugs.
Published Both high-protein and normal-protein diets are effective for T2D management
(via sciencedaily.com) Original source New findings indicate that the type of protein in the diet is not as important as the overall amount of weight loss for those with Type 2 diabetes. 106 adults with T2D were randomly assigned to either the high-protein or normal-protein diet for 52 weeks. Both diets were energy-restricted. The high-protein diet included recommendations to include lean beef in the diet, while the normal-protein diet instructed participants to refrain from eating any red meats. The team of researchers found that both a high-protein diet (40 percent of total calories from protein) and a moderate-protein diet (21 percent of total calories from protein) were effective in improving glucose control, weight loss and body composition in people with Type 2 diabetes.
Published 3D printing with coffee: Turning used grounds into caffeinated creations
(via sciencedaily.com) Original source Coffee could be the key to reducing 3D printing waste, according to a new study. Researchers have developed a method for 3D printing using a paste made out of old coffee grounds.
Published You say tomato, these scientists say evolutionary mystery
(via sciencedaily.com) Original source Biologists have found evidence for evolutionary 'syndromes'-- sets of traits that occur together -- that help to explain how tomatoes first evolved their distinctive blend of color, sweetness, acidity and aroma. The research not only shines a light on how fruits evolve in the wild, but will also be valuable to crop-improvement efforts aimed at breeding more nutritious and appealing varieties of fruits.
Published Super antifreeze in cells: The ability to survive in ice and snow developed in animals far earlier than we thought
(via sciencedaily.com) Original source More than 400 million years ago, an insect-like animal called the springtail developed a small protein that prevents its cells from freezing.
Published Researcher helps boost immune system memory against influenza
(via sciencedaily.com) Original source Researchers are one step closer to making the T cell army stronger. In a recent study, researchers found that by manipulating one molecular signaling pathway in the T cells that participate in clearing influenza virus in the lungs, the strength and longevity of immunological memory produced can be improved.
Published Auxin signaling pathway controls root hair formation for nitrogen uptake
(via sciencedaily.com) Original source Root hairs represent a low-cost strategy to enhance nutrient uptake because they can significantly increase the nutrient-acquiring surface of plant roots. While primary and lateral roots are stimulated to elongate when plants grow under mild nitrogen deficiency, the existence of such a foraging response for root hairs and its underlying regulatory mechanism remain elusive. Now, researchers have revealed a framework composed of specific molecular players meditating auxin synthesis, transport and signaling that triggers root hair elongation for nitrogen acquisition.
Published Malaria-causing parasites resistant to both treatment and detection have emerged in Ethiopia
(via sciencedaily.com) Original source Genomic surveillance has revealed mutations in malaria-causing parasites that will complicate efforts to eradicate the disease in Africa.
Published Scientific ocean drilling discovers dynamic carbon cycling in the ultra-deep-water Japan Trench
(via sciencedaily.com) Original source Hadal trenches, with their deepest locations situated in the so-called hadal zone, the deepest parts of the ocean in water depth >6km, are the least-explored environment on Earth, linking the Earth's surface and its deeper interior. An international team conducting deep-subsurface sampling in a hadal trench at high spatial resolution has revealed exciting insights on the carbon cycling in the trench sediment.