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Categories: Biology: Cell Biology, Geoscience: Geochemistry

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The rise of RNA viruses like SARS-CoV-2 highlights the need for new ways to fight them. RNA-targeting tools like CRISPR/Cas13 are powerful but inefficient in the cytoplasm of cells, where many RNA viruses replicate. Scientists have devised a solution: Cas13d-NCS. This new molecular tool allows CRISPR RNA molecules that are located within the nucleus of a cell to move to the cytoplasm, making it highly effective at neutralizing RNA viruses. This advancement opens doors for precision medicine and proactive viral defense strategies.

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Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide. While the immune system usually clears HPV infections, those that persist can lead to cancer, and a new finding suggests that certain women may have a genetic susceptibility for persistent or frequent HPV infections. These genetic variants could raise a woman's risk of getting cervical cancer from a high-risk HPV infection.

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Researchers reveal how DNA gyrase resolves DNA entanglements. The findings not only provide novel insights into this fundamental biological mechanism but also have potential practical applications. Gyrases are biomedical targets for the treatment of bacterial infections and the similar human versions of the enzymes are targets for many anti-cancer drugs. Better understanding of how gyrases work at the molecular level can potentially improve clinical treatments.

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Most disease-causing bacteria are known for their speed: In mere minutes, they can double their population, quickly making a person sick. But just as dangerous as this rapid growth can be a bacterium's resting state, which helps the pathogen evade antibiotics and contributes to severe chronic infections in the lungs and blood, within wounds, and on the surfaces of medical devices. Now, scientists have discovered how long chains of molecules called polyphosphates (polyP) are needed for bacteria to slow down movements within cells and let them enter this resting state.

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New research is shedding light on one barrier to a clean energy future: corrosion. Using nanoscale imaging techniques, researchers have captured high-resolution videos of tiny crystals of ruthenium dioxide -- a key ingredient used to produce clean-burning hydrogen -- as they are eaten away by their acidic environment. The research could pave the way to more durable catalysts and dramatically extend the lifetime of devices needed to turn hydrogen green.

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Parasites thought only to infect tropical coral reefs have been discovered in a large variety of creatures in cold marine ecosystems along the Northeast Pacific, according to new research.

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Researchers have created a method that extracts over 80 percent of the available protein in grain leftovers from brewing beer, commonly known as brewers' spent grain.

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Researchers show that ozone levels, such as those found in many places on hot summer days today, destroy the sex pheromones of fruit fly species. As a result, some natural mating boundaries maintained by species-specific pheromones no longer exist. The research team has shown in experiments that flies of different species mate when exposed to ozone and produce hybrid offspring. Since most of these offspring are unable to reproduce, the results could provide another explanation for the global decline of insects.

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Researchers have identified 14 genes that thale cress -- a plant commonly used in genetic investigations since its genome is well documented -- express more when responding to five specific stressors, as well as eight genes that the plant suppresses.

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Traces of DNA in the stomachs of predatory snails give a team og geobiologists new insights into the ecology of placozoans.

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Researchers have created a potential alternative to traditional petroleum-based plastic that is made from carbon dioxide (CO2) and lignin, a component of wood that is a low-cost byproduct of paper manufacturing and biofuel production.

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Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.

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Cells contain various specialized structures -- such as the nucleus, mitochondria or peroxisomes -- known as 'organelles'. Tracing their genesis and determining their structure is fundamental to understanding cell function and the pathologies linked to their dysfunction.

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A new study reveals the detailed protein structure of the TAS2R14, a bitter taste receptor that allows us to perceive bitter taste. In addition to solving the structure of this taste receptor, the researchers were also able to determine where bitter-tasting substances bind to TAS2R14 and how they activate them. The findings may lead to the development of drugs that targeting taste receptors.

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A research team has developed a broadband UV dual-comb spectrometer with which air pollutants can be continually measured and their reaction with the environment can be observed in real time.

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Researchers decode repair mechanism during transcription of genetic information.

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Engineered bacteria can produce a plastic modifier that makes renewably sourced plastic more processable, more fracture resistant and highly biodegradable even in sea water. The development provides a platform for the industrial-scale, tunable production of a material that holds great potential for turning the plastic industry green.

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Wirelessly connected devices perform an expanding array of applications, such as monitoring the condition of machinery and remote sensing in agricultural settings. These applications hold much potential for improving the efficiency, but how do you power these devices where reliable electrical sources are not available? Research points to a possible solution in the form of a novel type of battery.

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A team reveals a clear link between human-driven climate change and the years-long drought currently gripping southern Madagascar.

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Researchers have made a significant advancement toward understanding how the human genome is organized inside a single cell. This knowledge is crucial for analyzing how DNA structure influences gene expression and disease processes.