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Categories: Biology: Cell Biology, Geoscience: Oceanography
Published New method to help with analysis of single cell data
(via sciencedaily.com) Original source CITE-seq (cellular indexing of transcriptomes and epitopes) is an RNA sequencing-based method that simultaneously quantifies cell surface protein and transcriptomic data within a single cell readout. The ability to study cells concurrently offers unprecedented insights into new cell types, disease states or other conditions. While CITE-seq solves the problem of detecting a limited number of proteins while using single-cell sequencing in an unbiased way, one of its limitations is the high levels of background noise that can hinder analysis.
Published Heat tolerant coral may trade fast growth for resilience
(via sciencedaily.com) Original source Algae living within the soft tissue of coral supply much of the energy needed by their hosts, and some symbiotic algae help coral withstand warmer water better than others. Researchers have now found that there was a tradeoff for corals dominated by the thermally sensitive algae -- they have higher growth, but only in cooler water.
Published Rediscovery of rare marine amoeba Rhabdamoeba marina
(via sciencedaily.com) Original source Researchers have rediscovered and successfully cultivating Rhabdamoeba marina -- a rare marine amoeba that has only been reported in two cases in the past century. Using this culture strain, they performed a comprehensive analysis of its genetic sequence, revealing for the first time the phylogenetic position of this enigmatic amoeba, and proposed a novel taxonomic classification based on their research findings.
Published Research in Lake Superior reveals how sulfur might have cycled in Earth's ancient oceans
(via sciencedaily.com) Original source A scientists has sulfur on her mind. The yellow element is a vital macronutrient, and she's trying to understand how it cycles through the environment. Specifically, she's curious about the sulfur cycle in Earth's ancient ocean, some 3 billion years ago.
Published Genomic tug of war could boost cancer therapy
(via sciencedaily.com) Original source Researchers have discovered a 'genomic tug of war' in animal studies that could influence how well certain patients -- or certain cancers -- respond to decitabine, a drug used to treat myelodysplastic syndromes that is plagued by drug resistance issues. For the first time, researchers show that decitabine causes coding and non-coding regions of DNA to engage in a tug of war for a gene activator, called H2A.Z. Typically, deticabine draws this gene activator away from coding DNA, causing gene expression to grind to a halt and cells to die. However, many types of cancer have very high levels of H2A.Z, which may help them overcome this decitabine-induced tug of war, allowing the cancer to grow.
Published How cell identity is preserved when cells divide
(via sciencedaily.com) Original source A new theoretical model helps explain how epigenetic memories, encoded in chemical modifications of chromatin, are passed from generation to generation. Within each cell's nucleus, researchers suggest, the 3D folding patterns of its genome determines which parts of the genome will be marked by these chemical modifications.
Published Much more than waste: Tiny vesicles exchange genetic information between cells in the sea
(via sciencedaily.com) Original source Researchers take a look at data that has so far been mostly discarded as contamination, revealing the previously underestimated role of extracellular vesicles (EVs). These are important for the exchange of genetic information between cells and thus for the microbial community in the sea.
Published A healthy mouth helps to maintain balanced metabolic profiles
(via sciencedaily.com) Original source Common oral infections, periodontal diseases and caries, are associated with inflammatory metabolic profiles related to an increased risk of cardiometabolic diseases, a new study by an international team of researchers suggests. Oral infections also predicted future adverse changes in metabolic profiles.
Published Bear genes show circadian rhythms even during hibernation
(via sciencedaily.com) Original source The internal clocks of grizzly bears appear to keep ticking through hibernation, according to a genetic study. This persistence highlights the strong role of circadian rhythms in the metabolism of many organisms including humans. The genetic study confirmed observational evidence that bears' energy production still waxes and wanes in a daily pattern even as they slumber for several months without eating. The researchers also found that during hibernation the amplitude of the energy production was blunted, meaning the range of highs and lows was reduced. The peak also occurred later in the day under hibernation than during the active season, but the daily fluctuation was still there.
Published Hormones have the potential to treat liver fibrosis
(via sciencedaily.com) Original source Researchers have discovered previously unknown changes in a specific type of liver cells, potentially opening avenues for a new treatment for liver fibrosis, a potentially life-threatening condition. Currently, there are no drugs available to treat liver fibrosis.
Published Climate change effects hit marine ecosystems in multiple waves, according to marine ecologists
(via sciencedaily.com) Original source A new approach to examining the effects of climate change on marine ecosystems may provide a more accurate understanding of climate change responses -- and predictions for future consequences -- according to a new article. The paper highlights the interplay between the trend of climate warming and the fluctuations in local temperature. These two properties cause atypically warm events such as marine heatwaves to occur with increasing frequency and magnitude.
Published Ice cores from Earth's highest tropical peak provide insight into climate variability
(via sciencedaily.com) Original source A new study examines ice cores from the summit of the highest tropical mountain in the world, and finds unique insight into the climate record of the Amazon Basin over the last six decades.
Published How bacteria recognize viral invasion and activate immune defenses
(via sciencedaily.com) Original source Bacteria have an array of strategies to counter viral invasion, but how they first spot a stranger in their midst has long been a mystery.
Published Surveilling wetlands for infectious bird flu -- and finding it
(via sciencedaily.com) Original source Recently, morning omelets and holiday dinners have gotten more expensive. One likely cause is bird flu, outbreaks of which led to the deaths of millions of chickens and turkeys from infection or culling in 2022, according to the U.S. Department of Agriculture, and which still demands rigorous monitoring of wild populations. Now, researchers have developed a method that detected infectious bird flu virus in wetlands frequented by waterfowl.
Published Colliding ribosomes activate RNA repair
(via sciencedaily.com) Original source Researchers discover how ribosomes contribute to the recognition and removal of RNA crosslinking damage.
Published Unexpected discovery opens bioengineering opportunities for human and plant health
(via sciencedaily.com) Original source An unexpected genetic discovery in wheat has led to opportunities for metabolic engineering of versatile compounds with potential to improve its nutritional qualities and resilience to disease.
Published Climate engineering could slow Antarctic ice loss, study suggests
(via sciencedaily.com) Original source A study reports that scattering sunlight-reflecting particles in the atmosphere -- a theoretical form of climate engineering known as 'stratospheric aerosol injection' -- has potential to slow rapid ice melt in Western Antarctica.
Published Genetic discovery promises high-iron vegetables and cereals
(via sciencedaily.com) Original source A genetic breakthrough has opened new opportunities for iron-fortified vegetables and cereal crops to help address the global health issue of anemia.
Published Novel C. diff structures are required for infection, offer new therapeutic targets
(via sciencedaily.com) Original source Newly discovered iron storage 'ferrosomes' inside the bacterium C. diff -- the leading cause of hospital-acquired infections -- are important for infection in an animal model and could offer new targets for antibacterial drugs. They also represent a rare demonstration of a membrane-bound structure inside a pathogenic bacterium, upsetting the biological dogma that bacteria do not contain organelles.
Published Roaming seabirds need ocean-wide protection
(via sciencedaily.com) Original source Seabirds roam far and wide in the Indian Ocean -- so they need ocean-wide protection, new research shows.