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Categories: Biology: Cell Biology, Paleontology: Climate

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A new study shows the keto diet prevents early memory decline in mice. A molecule in the diet plays a key role in slowing Alzheimer's disease.

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A new study has challenged previously held views that brain preservation in the archaeological record is extremely rare. The team compiled a new archive of preserved human brains, which highlighted that nervous tissues actually persist in much greater abundances than traditionally thought, assisted by conditions that prevent decay.

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Biologists have published a chromosomally assembled reference genome for the European brown hare. The genome consists of 2.9 billion base pairs, which form 23 autosomal chromosomes, and X and Y sex chromosomes. The timing of the genome release is very appropriate as the brown hare also represents the original Easter Bunny familiar from European folklore.

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A new study finds a complex interplay between diet, genes, and the gut microbiota that could explain why IBD develops.

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Once thrown away, disposable diapers and sanitary pads can take hundreds of years to decompose, because they contain plastics and other synthetic polymers. But now, researchers are replacing these materials with components made from protein biomass that is often discarded. They are sustainable and biodegradable, and they could potentially allow future diapers and pads to be flushed down a toilet or used as fertilizer.

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Researchers have discovered that the mere act of attaching their microparticle 'backpacks' to neutrophils is enough to activate them against cancer -- no drugs needed. In experiments, backpack-bearing neutrophils shrank tumors and extended the survival of mice with cancer, and treated animals retained an immune memory of the disease. This approach opens the door to a new class of drug-free immunotherapy for cancer.

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In a series of trials involving trained distance runners, researchers found that ingesting a cranberry supplement for 28 consecutive days led to noticeable improvements in both performance and muscle fatigue following 1,500-metre time trials. Reoxygenation rates were faster and running speeds improved by 1.5 per cent. The researchers found that 28 days of cranberry extract consumption by elite level endurance runners demonstrated a trend toward increased speed in 1,500-metre time trials but not in 400-metre ones. However, they did notice that lactate buildup was reduced following the 400-metre but not the 1,500-metre compared to baseline. The data also indicated that the cranberry extract promoted better oxygen extraction by the muscle, improved lactate clearance and slower muscle deoxygenation.

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Human sweat contains a protein that may protect against Lyme disease. About one-third of the population carries a genetic variant of this protein that is associated with Lyme disease in genome-wide association studies.

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Some soil bacteria can acquire sets of genes that enable them to pump the heavy metal nickel out of their systems, a study has found. This enables the bacteria to not only thrive in otherwise toxic soils but help plants grow there as well. A research team pinpointed a set of genes in wild soil bacteria that allows them to do this in serpentine soils which have naturally high concentrations of toxic nickel. The genetic discovery could help inform future bioremediation efforts that seek to return plants to polluted soils.

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Heparin, the world's most widely used blood thinner, is used during procedures ranging from kidney dialysis to open heart surgery. Currently, heparin is derived from pig intestines, but scientists have discovered how to make it in the lab. They have also developed a path to a biomanufacturing process that could potentially revolutionize how the world gets its supply of this crucial medicine.

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Our eating habits in industrialized societies are far removed from those of ancient humans. This is impacting our intestinal flora, it seems, as newly discovered cellulose degrading bacteria are being lost from the human gut microbiome, especially in industrial societies.

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When climate scientists look to the future to determine what the effects of climate change may be, they use computer models to simulate potential outcomes such as how precipitation will change in a warming world. Some scientists are also looking at something a little more tangible: coral.

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The development of hair was of central importance for the evolution of mammals and thus also of humans. However, the evolutionary origin of the genetic program of hair was previously unknown. Researchers have now been able to show that important hair components and their genetic control have already evolved in amphibians. Human hair therefore shows unexpected similarities to the claws of clawed frogs.

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The curvature of a surface determines the migration behavior of biological cells. They preferentially move along valleys or grooves while avoiding ridges. These findings gave rise to a model predicting cellular behavior. Such universal principles now allow a better understanding of the migration of immune and cancer cells, paving the way for new treatment options.

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In a first for the condensate field, researchers have figured out how nucleolar sub-structures are assembled. This organization gives rise to unique pH profiles within nucleoli, which they measured and compared with the pH of nearby non-nucleolar condensates including nuclear speckles and Cajal bodies.

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Eating fatty food in the days leading up to surgery may prompt a heightened inflammatory response in the brain that interferes for weeks with memory-related cognitive function in older adults -- and, new research in animals suggests, even in young adults.

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Research has demonstrated individual differences in and successfully extracted commonalities from the whole-brain activity of roundworms. The researchers also found that computer simulations based on the whole-brain activity of roundworms more accurately reflect real-brain activity when they include so-called 'noise,' or probabilistic elements.

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Researchers have created a DNA origami platform called DoriVac, whose core component is a self-assembling square block-shaped nanostructure. DoriVac vaccines enabled tumor-bearing mice to better control the growth of tumors and to survive significantly longer than control mice.

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Making a personalized T cell therapy for cancer patients currently takes at least six months. Scientists have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.

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Perfectly adapted microorganisms live in extreme environments from deep-sea trenches to mountaintops. Learning more about how these extremophiles survive in hostile conditions could inform scientists about life on Earth and potential life on other planets.