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Categories: Biology: Cell Biology, Offbeat: Space
Published First ever 3D reconstruction of 52,000-year-old woolly mammoth chromosomes thanks to serendipitously freeze-dried skin
(via sciencedaily.com) Original source An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample. The fossilized chromosomes, which are around a million times longer than most ancient DNA fragments, provide insight into how the mammoth's genome was organized within its living cells and which genes were active within the skin tissue from which the DNA was extracted. This unprecedented level of structural detail was retained because the mammoth underwent freeze-drying shortly after it died, which meant that its DNA was preserved in a glass-like state.
Published Researchers pinpoint brain cells that delay first bite of food
(via sciencedaily.com) Original source Do you grab a fork and take a first bite of cake, or say no and walk away? Our motivation to eat is driven by a complex web of cells in the brain that use signals from within the body, as well as sensory information about the food in front of us, to determine our behaviors. Now, scientists have identified a group of neurons in a small and understudied region of the brain -- the parasubthalamic nucleus (PSTN) -- that controls when an animal decides to take a first bite of food.
Published Novel genome editing approach restores hearing in adult preclinical models with genetic deafness
(via sciencedaily.com) Original source Researchers restored hearing in preclinical mouse models with a specific form of inherited deafness called DFNA50 caused by mutations in microRNA, by using a novel in vivo CRISPR genome editing approach. Since mouse and human microRNAs have identical sequences, the researchers hope this work can one day be translated into applications for humans.
Published Mars likely had cold and icy past, new study finds
(via sciencedaily.com) Original source The question of whether Mars ever supported life has captivated the imagination of scientists and the public for decades. Central to the discovery is gaining insight into the past climate of Earth's neighbor: was the planet warm and wet, with seas and rivers much like those found on our own planet? Or was it frigid and icy, and therefore potentially less prone to supporting life as we know it? A new study finds evidence to support the latter by identifying similarities between soils found on Mars and those of Canada's Newfoundland, a cold subarctic climate.
Published Atlas of proteins reveals inner workings of cells
(via sciencedaily.com) Original source Researchers discover how proteins behave inside cells using AI, which has the potential to guide drug design.
Published Discovery of a new defense mechanism in bacteria
(via sciencedaily.com) Original source When confronted with an antibiotic, toxic substance, or other source of considerable stress, bacteria are able to activate a defense mechanism using cell-to-cell communication to 'warn' unaffected bacteria, which can then anticipate, shield themselves and spread the warning signal.
Published Not so simple: Mosses and ferns offer new hope for crop protection
(via sciencedaily.com) Original source Mosses, liverworts, ferns and algae may offer an exciting new research frontier in the global challenge of protecting crops from the threat of disease.
Published The origins of dark comets
(via sciencedaily.com) Original source Up to 60% of near-Earth objects could be dark comets, mysterious asteroids that orbit the sun in our solar system that likely contain or previously contained ice and could have been one route for delivering water to Earth, according to a new study.
Published The detection of a massive harmful algal bloom in the Arctic prompts real-time advisories to western Alaskan communities
(via sciencedaily.com) Original source A summer 2022 research cruise that detected a massive and highly toxic harmful algal bloom (HAB) in the Bering Strait has provided a dramatic example of science that utilized new technology to track a neurotoxic HAB and effectively communicate that information in real-time to protect remote communities in coastal Alaska.
Published Phage-derived enzyme targets E. faecalis biofilms to mitigate acute graft-versus-host disease
(via sciencedaily.com) Original source Acute graft-versus-host disease occurs when donor immune cells attack the recipient's tissues after an allogeneic hematopoietic stem cell transplantation (allo-HCT). Researchers recently identified a bacteriophage-derived enzyme called endolysin capable of targeting biofilms formed by Enterococcus faecalis. Their findings offer hope for tailored interventions in allo-HCT.
Published Discovery could help reduce adverse side effects of popular next-generation obesity medications
(via sciencedaily.com) Original source By teasing apart the therapeutic benefits from the adverse effects of new generation obesity medications, researchers found a population of neurons in the brain that controls food intake without causing nausea in an animal model.
Published Big gain in battle against harmful bacteria
(via sciencedaily.com) Original source An unexpected find has enabled important progress to be made in the battle against harmful bacteria.
Published The plague may have caused the downfall of the Stone Age farmers
(via sciencedaily.com) Original source Ancient DNA from bones and teeth hints at a role of the plague in Stone Age population collapse. Contrary to previous beliefs, the plague may have diminished Europe's populations long before the major plague outbreaks of the Middle Ages, new research shows.
Published Strong evidence for intermediate-mass black hole in Omega Centauri
(via sciencedaily.com) Original source Most known black holes are either extremely massive, like the supermassive black holes that lie at the cores of large galaxies, or relatively lightweight, with a mass of under 100 times that of the Sun. Intermediate-mass black holes (IMBHs) are scarce, however, and are considered rare 'missing links' in black hole evolution.
Published Found with Webb: A potentially habitable icy world
(via sciencedaily.com) Original source A international team of astronomers has made an exciting discovery about the temperate exoplanet LHS 1140 b: it could be a promising 'super-Earth' covered in ice or water.
Published New one-step method to make multiple edits to a cell's genome
(via sciencedaily.com) Original source A team of scientists have developed a new method that enables them to make precise edits in multiple locations within a cell -- all at once. Using molecules called retrons, they created a tool that can efficiently modify DNA in bacteria, yeast, and human cells.
Published New way for beneficial microbes to survive extreme conditions and space exploration
(via sciencedaily.com) Original source Investigators sought to help figure out how to send materials like probiotics into space and to better treat a variety of gastrointestinal (GI) and metabolic diseases. The team's formulations allow microbial therapeutics, including those used to treat gastrointestinal diseases and improve crop production, to maintain their potency and function over time despite extreme temperatures.
Published Stench of a gas giant? Nearby exoplanet reeks of rotten eggs, and that's a good thing
(via sciencedaily.com) Original source An exoplanet infamous for its deadly weather has been hiding another bizarre feature -- it reeks of rotten eggs, according to a new study of data from the James Webb Space Telescope.
Published A gut microbe could hold a key to help people benefit from healthy foods
(via sciencedaily.com) Original source In a study involving 50,000+ individuals from around the world, higher gut levels of Blastocystis, a single-celled organism commonly found in the digestive system, were linked to more favorable indicators of health.
Published Ancient dingo DNA shows modern dingoes share little ancestry with modern dog breeds
(via sciencedaily.com) Original source A study of ancient dingo DNA revealed that the distribution of modern dingoes across Australia, including those on K'gari (formerly Fraser Island), pre-dates European colonization and interventions like the dingo-proof fence.