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Categories: Biology: Cell Biology, Offbeat: Computers and Math

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Bioengineers around the world have been working to create plastic-producing microbes that could replace the petroleum-based plastics industry. Now, researchers have overcome a major hurdle: getting bacteria to produce polymers that contain ring-like structures, which make the plastics more rigid and thermally stable. Because these molecules are usually toxic to microorganisms, the researchers had to construct a novel metabolic pathway that would enable the E. coli bacteria to both produce and tolerate the accumulation of the polymer and the building blocks it is composed of. The resulting polymer is biodegradable and has physical properties that could lend it to biomedical applications such as drug delivery, though more research is needed.

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Researchers identified a signaling pathway in mice that boosts intestinal stem cells' regeneration abilities after fasting. When cancerous mutations occurred during this regenerative period, mice were more likely to develop early-stage intestinal tumors.

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A newly identified identified cellular mechanism allows mitochondria to recycle localized damage and maintain healthy function.

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A tandem signaling process turns ordinary cells into an efficient cleanup crew.

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A team of researchers has discovered that an antioxidant found in rosemary extract can reduce volitional intakes of cocaine by moderating the brain's reward response, offering a new therapeutic target for treating addiction.

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Scientists have found a new way to predict how proteins change their shape when they function, which is important for understanding how they work in living systems. While recent artificial intelligence (AI) technology has made it possible to predict what proteins look like in their resting state, figuring out how they move is still challenging because there is not enough direct data from experiments on protein motions to train the neural networks.

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A study in mice has found that the bacteria Bifidobacterium breve in the mother's gut during pregnancy supports healthy brain development in the fetus.

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Researchers have shown how and why the depletion of microbes in a newborn's gut by antibiotics can lead to lifelong respiratory allergies. The research team identified a specific cascade of events that lead to allergies and asthma, opening many new avenues for exploring potential preventions and treatments.

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Researchers have discovered RNA mechanisms that may lead to more effective, durable and targeted treatments for conditions like high cholesterol, liver diseases and cancers.

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Scientists are finding clues for how to treat diabetes and hormone disorders in an unexpected place: a toxin from one of the most venomous animals on the planet.

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A new adaptive 3D printing system can identify the positions of randomly distributed organisms and safely move them to specific locations for assembly.

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A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA. The research could reshape scientists' understanding of gene regulation and how genetic variations may influence gene expression in development or disease.

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Researchers have identified the genetic changes linked to why plants go through a developmental change similar to 'puberty' at different rates, a discovery which could lead to better crop nutrition.

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Researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease. The study found phenylacetylglutamine (PAG), produced by gut bacteria as a waste product, then absorbed and formed in the liver, interacts with previously undiscovered locations on beta-2 adrenergic receptors on heart cells once it enters the circulation.

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James Joyce's tome 'Finnegans Wake' famously breaks the rules of normal prose through its unusual, dreamlike stream of consciousness, and new work in chaos theory takes a closer look at how Joyce's challenging novel stands out mathematically. Researchers compared the distribution of punctuation marks in various experimental novels to determine the underlying order of 'Finnegans Wake' and by statistically analyzing the texts, researchers found the tome exhibits an unusual but statistically identifiable structure. The wide singularity spectrum was perfectly symmetrical, meaning sentence length variability follows an orderly curve.

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If you've visited a trendy cafe in the past few years, you might have noticed 'golden' turmeric milk on the menu. This fancy drink is caffeine-free, coffee-free and can even be vegan. And now, researchers have developed an efficient method to make a powdered, plant-based, instant version that maintains the beneficial properties of the ingredients while also extending its shelf life.

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When a global pandemic forced previous a graduate student out of the lab and onto the computer, he found a world of difference hidden in the long-studied species of Botryoccocus braunii -- and discovered that it isn't one species at all, but three.

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The avian influenza virus needs to mutate to cross the species barrier and to infect and replicate within mammalian cells. Scientists have now deciphered the structure of the avian influenza virus's polymerase when it interacts with a human protein essential for the virus to replicate within the cell. The structure of this replication complex provides important information about the mutations that avian influenza polymerase must undergo to adapt to mammals, including humans. These results can help scientists monitor the evolution and adaptability of bird flu strains, such as H5N1 or H7N9, towards infecting other species.

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The sea anemone Nematostella vectensis is potentially immortal. Using molecular genetic methods, developmental biologists have now identified possible candidates for multipotent stem cells in the sea anemone for the first time. These stem cells are regulated by evolutionary highly conserved genes.

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A new animal study shows that exposure to immune-stimulating proteins left behind by COVID-19 leads to lower cortisol, brain inflammation and a heightened reaction to subsequent stressors.