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Categories: Biology: Cell Biology, Offbeat: Paleontology and Archeology

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Life on a faraway planet -- if it's out there -- might not look anything like life on Earth. But there are only so many chemical ingredients in the universe's pantry, and only so many ways to mix them. Scientists have now exploited those limitations to write a cookbook of hundreds of chemical recipes with the potential to give rise to life. Their ingredient list could focus the search for life elsewhere in the universe by pointing out the most likely conditions -- planetary versions of mixing techniques, oven temperatures and baking times -- for the recipes to come together.

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A new study conducted in a lab -- with follow-up human breath tests being planned -- showed that whole milk plain yogurt prevented almost all of the volatile compounds responsible for garlic's pungent scent from escaping into the air.

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Researchers have developed a way of detecting the early onset of deadly infectious diseases using a test so ultrasensitive that it could someday revolutionize medical approaches to epidemics. The test is an electronic sensor contained within a computer chip. It employs nanoballs -- microscopic spherical clumps made of tinier particles of genetic material -- and combines that technology with advanced electronics.

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A new study sheds new light on the origins of modern brain cells. Researchers find evidence that specialized secretory cells found in placozoans, tiny sea creatures the size of a grain of sand, have many similarities to the neuron, such as the genes required to create a partial synapse. From an evolutionary point of view, early neurons might have started as something like these cells, eventually gaining the ability to create a complete synapse, form axons and dendrites and create ion channels that generate fast electrical signals -- innovations which gave rise to the neuron in more complex animals such as jellyfish. Though the complete story of how the first neuron appeared remains to be told, the study demonstrates that the basic building blocks for our brain cells were forming in the ancestors of placozoans grazing inconspicuously in the shallow seas of Earth around 800 million years ago.

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A new study shows the isolation and sequencing of more than a century-old RNA molecules from a Tasmanian tiger specimen preserved at room temperature in a museum collection. This resulted in the reconstruction of skin and skeletal muscle transcriptomes from an extinct species for the first time. The researchers note that their findings have relevant implications for international efforts to resurrect extinct species, including both the Tasmanian tiger and the woolly mammoth, as well as for studying pandemic RNA viruses.

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Scientists are investigating the previously largely unknown biosynthetic pathway that leads to the formation of cardenolides in plants. In a new study, they present two enzymes from the CYP87A family as key enzymes that catalyze the formation of pregnenolone, the precursor for the biosynthesis of plant steroids, in two different plant families. The discovery of such enzymes should help to develop platforms for the cheap and sustainable production of high quality steroid compounds for medical use.

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Microbiologists have discovered a new intestinal microbe that feeds exclusively on taurine and produces the foul-smelling gas hydrogen sulfide. The researchers have thus provided another building block in the understanding of those microbial processes that have fascinating effects on health. This is also true of Taurinivorans muris: the bacterium shows a protective function against Klebsiella and Salmonella, two important pathogens.

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It takes over the brains of ants, causing them to cling to blades of grass against their will. The lancet liver fluke has an exceptional lifecycle strategy, in which snails, ants and grazing animals are unwitting actors. Researchers now reveal more about the mind-bending workings of this tiny parasite.

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Tweaks to the mitochondrial genome hold the potential for better hybrid seed production or to introduce seedless fruits.

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A new study finds poor quality of available foods, increased intake of calories from foods high in trans-fatty acids, and environments that do not foster physical activity, all prevalent in disadvantaged neighborhoods, disrupt the flexibility of information processing in the brain that is involved in reward, emotion regulation, and cognition.

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Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded 'nicks' in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.

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Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.

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R esearchers created a machine learning algorithm using computational topology that profiles shapes and spatial patterns in embryos to study how these cells organize themselves into tissue-like architectures. In a new study, they take that system to the next level, opening a path to studying how multiple types of cells assemble themselves.

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Researchers have characterized a specialized type of immune cell, which plays a key role in protecting and repairing the cells in the healthy human gut.

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Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail. By understanding how different tissues tackle protein build up, this research could accelerate the identification of ways to protect tissues that are vulnerable to protein build up, possibly tackling both disease-associated protein aggregates and also age-dependent aggregates that accelerate the functional decline of tissues.

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Researchers have successfully demonstrated that hagfish slime proteins can accurately replicate membranes in the human eye. Scientists were able to properly grow retinal cells on hagfish slime proteins and prove that the protein's behavior changes as the membrane mimics stages of aging and disease.

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During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity. These long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes and reside there permanently as the first layer of defense that can quickly react to produce antibodies in a future infection.

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Some crop pathogens use a clever trick to multiply and spread infection: they hijack the plant's cellular plumbing. In a new study, researchers unveil a class of bacterial proteins that fold into a straw-like shape and insert themselves into the plant cell membrane, allowing the inside of the leaf to become waterlogged. The researchers also figured out a possible way to block the water channel proteins and prevent infection.

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Scientists identify a new and surprising function of a membrane protein on the surface of cancer cells: It supports and stabilizes an important 'co-stimulatory' factor that enhances the activation of T cells, thus improving the immune response against the tumor.

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The very first life on earth is thought to have developed from 'protocells' -- liquid mixtures of many different types of molecules. Researchers have now shown that in such mixtures, small imbalances in the number of molecules of different types can have an unexpected effect. A surprising interplay with the complex pattern of interactions strongly amplifies such imbalances -- meaning that a type of molecule that is only slightly in the majority can almost entirely separate out from the others. These fundamental findings point towards a new mechanism that will apply in many complex mixtures. For instance, this would be a way for cells to control the formation of structures by fine-tuning the concentration of different molecules.