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Categories: Biology: Cell Biology, Chemistry: Biochemistry

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Who are we? Why are we here? We are stardust, the result of chemistry occurring throughout vast clouds of interstellar gas and dust. To better understand how that chemistry could create prebiotic molecules, researchers investigated the role of low-energy electrons created as cosmic radiation traverses through ice particles. Their findings may also inform medical and environmental applications on our home planet.

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In preclinical models, the inhalation of a mixture of living Lactobacilli bacteria attenuated pulmonary inflammation and improved lung function and structure for the chronic lung diseases bronchopulmonary dysplasia and chronic obstructive pulmonary disease. This study determined the mechanism of this live biotherapeutic product -- a powder mixture of living Lactobacilli bacteria -- to reduce neutrophilic inflammation and reduce a broad swath of inflammatory markers in BPD and COPD.

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The distribution of outermost shell electrons, known as valence electrons, of organic molecules was observed for the first time. As the interactions between atoms are governed by the valence electrons, the findings shine light on the fundamental nature of chemical bonds, with implications for pharmacy and chemical engineering.

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Researchers have succeeded in forming metal-organic framework thin films on a substrate while controlling the growth direction of crystals so that they are arranged neatly without gaps. The resulting thin films of unprecedented high quality can be expected for use as optical sensors, optical elements, and transparent gas adsorption sheets.

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Epigenetics confers a survival advantage in plants to endure harsh weather by inducing bud dormancy. Environmental factors or intrinsic signals trigger the transition between growth and dormancy. Researchers explore the role of chromatin and transcriptional changes in the bud and further analyze data using artificial intelligence models. The findings of this study highlight epigenetic strategies to overcome the effects of short winters during global warming for plant survival.

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For nearly a century, scientists have waged war on antibiotic-resistant microbes. Researchers say they've found a new way to prevent it -- by unleashing 'DNA scavengers' in wastewater treatment plants.

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Bioengineers around the world have been working to create plastic-producing microbes that could replace the petroleum-based plastics industry. Now, researchers have overcome a major hurdle: getting bacteria to produce polymers that contain ring-like structures, which make the plastics more rigid and thermally stable. Because these molecules are usually toxic to microorganisms, the researchers had to construct a novel metabolic pathway that would enable the E. coli bacteria to both produce and tolerate the accumulation of the polymer and the building blocks it is composed of. The resulting polymer is biodegradable and has physical properties that could lend it to biomedical applications such as drug delivery, though more research is needed.

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Researchers identified a signaling pathway in mice that boosts intestinal stem cells' regeneration abilities after fasting. When cancerous mutations occurred during this regenerative period, mice were more likely to develop early-stage intestinal tumors.

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Scientists studying the tracks of particles streaming from six billion collisions of atomic nuclei at the Relativistic Heavy Ion Collider (RHIC) -- an 'atom smasher' that recreates the conditions of the early universe -- have discovered a new kind of antimatter nucleus, the heaviest ever detected. Composed of four antimatter particles -- an antiproton, two antineutrons, and one antihyperon -- these exotic antinuclei are known as antihyperhydrogen-4.

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A newly identified identified cellular mechanism allows mitochondria to recycle localized damage and maintain healthy function.

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A tandem signaling process turns ordinary cells into an efficient cleanup crew.

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Physicists have developed a new model that describes how filaments assemble into active foams.

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Researchers have developed molecular wires with periodic twists. By controlling the lengths of regions between twists, the electrical conductivity of individual polymer chains can be enhanced. This work may lead to novel organic electronics or single-molecule wires.

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A team of researchers has discovered that an antioxidant found in rosemary extract can reduce volitional intakes of cocaine by moderating the brain's reward response, offering a new therapeutic target for treating addiction.

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Scientists have found a new way to predict how proteins change their shape when they function, which is important for understanding how they work in living systems. While recent artificial intelligence (AI) technology has made it possible to predict what proteins look like in their resting state, figuring out how they move is still challenging because there is not enough direct data from experiments on protein motions to train the neural networks.

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A study in mice has found that the bacteria Bifidobacterium breve in the mother's gut during pregnancy supports healthy brain development in the fetus.

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Researchers have shown how and why the depletion of microbes in a newborn's gut by antibiotics can lead to lifelong respiratory allergies. The research team identified a specific cascade of events that lead to allergies and asthma, opening many new avenues for exploring potential preventions and treatments.

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Researchers have discovered RNA mechanisms that may lead to more effective, durable and targeted treatments for conditions like high cholesterol, liver diseases and cancers.

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Researchers have succeeded in something that has been pursued since the 1970s: explaining the X-ray radiation from the black hole surroundings. The radiation originates from the combined effect of the chaotic movements of magnetic fields and turbulent plasma gas.

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Scientists are finding clues for how to treat diabetes and hormone disorders in an unexpected place: a toxin from one of the most venomous animals on the planet.