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Categories: Biology: Cell Biology, Chemistry: Biochemistry
Published Prying open the AI black box
(via sciencedaily.com) Original source Meet SQUID, a new computational tool. Compared with other genomic AI models, SQUID is more consistent, reduces background noise, and can yield better predictions regarding critical mutations. The new system aims to bring scientists closer to their findings' true medical implications.
Published Controlling electronics with light: The magnetite breakthrough
(via sciencedaily.com) Original source Researchers have discovered that by shining different wavelengths (colors) of light on a material called magnetite, they can change its state, e.g. making it more or less conducive to electricity. The discovery could lead to new ways of designing new materials for electronics such as memory storage, sensors, and other devices that rely on fast and efficient material responses.
Published Membrane protein analogues could accelerate drug discovery
(via sciencedaily.com) Original source Researchers have created a deep learning pipeline for designing soluble analogues of key protein structures used in pharmaceutical development, sidestepping the prohibitive cost of extracting these proteins from cell membranes.
Published Lab-grown muscles reveal mysteries of rare muscle diseases
(via sciencedaily.com) Original source Biomedical engineers have grown muscles in a lab to better understand and test treatments for a group of extremely rare muscle disorders called dysferlinopathy or limb girdle muscular dystrophies 2B (LGMD2B). The research revealed the biological mechanisms underlying the disease and showed that a combination of existing treatments could alleviate its symptoms.
Published How to make aging a 'fairer game' for all wormkind
(via sciencedaily.com) Original source Researchers have discovered a new fundamental mechanism governing the rules of ageing in worms. The researchers were able to manipulate the mechanism through genetic interventions which dramatically extend not just the lifespan of the worms, but also their health-span. In other words, trading weak, frail old age with vigorous golden years -- all without altering their diet, environment or other external factors.
Published Scientists discover new behavior of membranes that could lead to unprecedented separations
(via sciencedaily.com) Original source Argonne scientists have used isoporous membranes -- membranes with pores of equal size and shape -- and recirculation to create separations at the nanoscale that overcome previous limitations.
Published Scientists devise algorithm to engineer improved enzymes
(via sciencedaily.com) Original source Scientists have prototyped a new method for 'rationally engineering' enzymes to deliver improved performance. They have devised an algorithm, which takes into account an enzyme's evolutionary history, to flag where mutations could be introduced with a high likelihood of delivering functional improvements. Their work could have significant, wide-ranging impacts across a suite of industries, from food production to human health.
Published Creation of a power-generating, gel electret-based device
(via sciencedaily.com) Original source A team of researchers has developed a gel electret capable of stably retaining a large electrostatic charge. The team then combined this gel with highly flexible electrodes to create a sensor capable of perceiving low-frequency vibrations (e.g., vibrations generated by human motion) and converting them into output voltage signals. This device may potentially be used as a wearable healthcare sensor.
Published Wild yeasts from Patagonia could yield new flavors of lagers
(via sciencedaily.com) Original source New strains of yeast for brewing lager beers, created by hybridizing wild strains of yeast from Patagonia with brewer's yeast, can yield novel flavors and aromas, researchers report.
Published Transforming inexpensive quinolines into complex drug candidates
(via sciencedaily.com) Original source An innovative synthesis strategy opened up the way to 2D/3D fused frameworks using inexpensive quinolines as feedstock, report scientists. By leveraging a light-sensitive borate intermediate, the scientists could transform quinoline derivatives into a great variety of 2D/3D fused frameworks in a straightforward and cost-effective manner. Their findings are expected to enable the synthesis of highly customizable drug candidates.
Published A railroad of cells
(via sciencedaily.com) Original source Looking under the microscope, a group of cells slowly moves forward in a line, like a train on the tracks. The cells navigate through complex environments. A new approach now shows how they do this and how they interact with each other.
Published Much of the Nord Stream gas remained in the sea
(via sciencedaily.com) Original source Much of the methane released into the southern Baltic Sea from the Nord Stream gas pipeline has remained in the water. This is shown by measurements taken by researchers from the University of Gothenburg.
Published New technology provides electrifying insights into how catalysts work at the atomic level
(via sciencedaily.com) Original source A team has invented a technique to study electrochemical processes at the atomic level with unprecedented resolution. They have already used it to discover a surprising phenomena in a popular catalyst material and plan to apply their technology to studying a wide variety of electrochemical systems including batteries, fuel cells, and solar fuel generators. The insights could lead to more efficient and durable devices.
Published Researchers create new class of materials called 'glassy gels'
(via sciencedaily.com) Original source Researchers have created a new class of materials called 'glassy gels' that are very hard and difficult to break despite containing more than 50% liquid. Coupled with the fact that glassy gels are simple to produce, the material holds promise for a variety of applications.
Published Mirror-image chemicals may revolutionize drug delivery
(via sciencedaily.com) Original source More than 130 years after cyclodextrins were first discovered and reported, a team of scientists has created chemical mirror images of these complex carbohydrates in the laboratory. This discovery may revolutionize how medications are delivered to patients.
Published Is coffee good for you or bad for you?
(via sciencedaily.com) Original source The effects of coffee consumption on human health is a knotty question, but one thing is sure: coffee is a psychoactive substance.
Published How targeted nutrients can fight cancer
(via sciencedaily.com) Original source An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells.
Published The world's oldest wine discovered
(via sciencedaily.com) Original source A white wine over 2,000 years old, of Andalusian origin, is the oldest wine ever discovered.
Published Unveiling Telo-seq: A breakthrough in telomere research on aging and cancer
(via sciencedaily.com) Original source Telo-seq -- a new tool -- is bringing telomere science into its modern era. Scientists can finally explore questions about the role of telomeres in aging and cancer that were not accessible with previous methods. The findings will inspire novel telomere-targeting therapeutics for aging-related diseases.
Published Where to put head and tail?
(via sciencedaily.com) Original source Formation of the body axes is a critical part of embryonic development. They guarantee that all body parts end up where they belong and that no ears grow on our backs. The head-tail axis, for example, determines the orientation of the two ends of the body. It was previously assumed that this axis is largely determined by the interplay between the Nodal and BMP signals. However, there appears to be another player in this system, as researchers have now discovered by using an embryo-like model system they developed. In the absence of BMP, the signalling molecule beta-catenin takes on the role of the Nodal antagonist. This new mechanism could be a flexible solution for axis formation in embryos with different shapes.