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Categories: Biology: Cell Biology

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A team of researchers has discovered a set of methods that enabled the first successful CRISPR-based genome editing in Nile grass rats.

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Bioengineers have harnessed the lotus effect to develop a system for culturing cancer cell clusters that can shed light on hard-to-study tumor properties. The new zinc oxide-based culturing surface mimics the lotus leaf surface structure, providing a highly tunable platform for the high-throughput generation of three-dimensional nanoscale tumor models.

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The elimination of damaged cell components is essential for the maintenance of the body's tissues and organs. An international research team has made significant findings on mechanisms for the clearing of cellular wastes, showing that strength training activates such mechanisms. The findings could form the basis for new therapies for heart failure and nerve diseases, and even afford benefits for manned space missions.

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A new study has used a series of innovative field experiments to show how plants combine circadian clock signals with environmental cues under naturally fluctuating conditions.

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Chlamydiae are sexually transmitted pathogens that can apparently survive in the human gut for a long time.

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While a mosquito bite is often no more than a temporary bother, in many parts of the world it can be scary. One mosquito species, Aedes aegypti, spreads the viruses that cause over 100,000,000 cases of dengue, yellow fever, Zika and other diseases every year. Another, Anopheles gambiae, spreads the parasite that causes malaria. The World Health Organization estimates that malaria alone causes more than 400,000 deaths every year. Indeed, their capacity to transmit disease has earned mosquitoes the title of deadliest animal.

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Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs. Until now however, examining DNA molecules one-by-one was a slow process. Biophysicists have developed a technique that speeds up screening of individual DNA molecules at least a thousand times. With this technology, they can measure millions of DNA molecules within a week instead of years to decades.

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Mono Lake is a beautiful but harsh environment, its salty and arsenic-laced water home to brine shrimp, alkali flies and little else. Scientists recently discovered an unsuspected resident, however, a microscopic creature -- a choanoflagelatte -- that forms colonies that harbor their own unique bacterial microbiomes. The creature, part of the sister group to all animals, could shed light on the evolution of animals' intimate interactions with bacteria and the rise of multicellular life.

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Managing hard-to-treat respiratory illnesses like asthma and pulmonary fibrosis just got easier if a new drug-carrying molecule is as sneaky as its inventors think.

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A new flu vaccine candidate incorporates proteins from 8 strains of influenza.

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In a struggle that probably sounds familiar to dieters everywhere, the less a Caenorhabditis elegans (C. elegans) worm eats, the more slowly it loses fat. Now, scientists have discovered why: a small molecule produced by the worms' intestines during fasting travels to the brain to block a fat-burning signal during this time.

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When you get infected with a virus, some of the first weapons your body deploys to fight it were passed down to us from our microbial ancestors billions of years ago. According to new research, two key elements of our innate immune system came from a group of microbes called Asgard archaea.

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New research shows that rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived.

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In preclinical models, the inhalation of a mixture of living Lactobacilli bacteria attenuated pulmonary inflammation and improved lung function and structure for the chronic lung diseases bronchopulmonary dysplasia and chronic obstructive pulmonary disease. This study determined the mechanism of this live biotherapeutic product -- a powder mixture of living Lactobacilli bacteria -- to reduce neutrophilic inflammation and reduce a broad swath of inflammatory markers in BPD and COPD.

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Epigenetics confers a survival advantage in plants to endure harsh weather by inducing bud dormancy. Environmental factors or intrinsic signals trigger the transition between growth and dormancy. Researchers explore the role of chromatin and transcriptional changes in the bud and further analyze data using artificial intelligence models. The findings of this study highlight epigenetic strategies to overcome the effects of short winters during global warming for plant survival.

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For nearly a century, scientists have waged war on antibiotic-resistant microbes. Researchers say they've found a new way to prevent it -- by unleashing 'DNA scavengers' in wastewater treatment plants.

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Bioengineers around the world have been working to create plastic-producing microbes that could replace the petroleum-based plastics industry. Now, researchers have overcome a major hurdle: getting bacteria to produce polymers that contain ring-like structures, which make the plastics more rigid and thermally stable. Because these molecules are usually toxic to microorganisms, the researchers had to construct a novel metabolic pathway that would enable the E. coli bacteria to both produce and tolerate the accumulation of the polymer and the building blocks it is composed of. The resulting polymer is biodegradable and has physical properties that could lend it to biomedical applications such as drug delivery, though more research is needed.

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Researchers identified a signaling pathway in mice that boosts intestinal stem cells' regeneration abilities after fasting. When cancerous mutations occurred during this regenerative period, mice were more likely to develop early-stage intestinal tumors.

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A newly identified identified cellular mechanism allows mitochondria to recycle localized damage and maintain healthy function.

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A tandem signaling process turns ordinary cells into an efficient cleanup crew.