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Categories: Biology: Genetics, Physics: Acoustics and Ultrasound
Published Cell's 'garbage disposal' may have another role: Helping neurons near skin sense the environment
(via sciencedaily.com) Original source The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but researchers, studying nerve cells grown in the lab and mice, say that the proteasome's role may go well beyond that.
Published How seaweed became multicellular
(via sciencedaily.com) Original source A deep dive into macroalgae genetics has uncovered the genetic underpinnings that enabled macroalgae, or 'seaweed,' to evolve multicellularity. Three lineages of macroalgae developed multicellularity independently and during very different time periods by acquiring genes that enable cell adhesion, extracellular matrix formation, and cell differentiation, researchers report. Surprisingly, many of these multicellular-enabling genes had viral origins. The study, which increased the total number of sequenced macroalgal genomes from 14 to 124, is the first to investigate macroalgal evolution through the lens of genomics.
Published Innovative antiviral defense with new CRISPR tool
(via sciencedaily.com) Original source The rise of RNA viruses like SARS-CoV-2 highlights the need for new ways to fight them. RNA-targeting tools like CRISPR/Cas13 are powerful but inefficient in the cytoplasm of cells, where many RNA viruses replicate. Scientists have devised a solution: Cas13d-NCS. This new molecular tool allows CRISPR RNA molecules that are located within the nucleus of a cell to move to the cytoplasm, making it highly effective at neutralizing RNA viruses. This advancement opens doors for precision medicine and proactive viral defense strategies.
Published Researchers identify new genetic risk factors for persistent HPV infections
(via sciencedaily.com) Original source Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide. While the immune system usually clears HPV infections, those that persist can lead to cancer, and a new finding suggests that certain women may have a genetic susceptibility for persistent or frequent HPV infections. These genetic variants could raise a woman's risk of getting cervical cancer from a high-risk HPV infection.
Published First step to untangle DNA: Supercoiled DNA captures gyrase like a lasso ropes cattle
(via sciencedaily.com) Original source Researchers reveal how DNA gyrase resolves DNA entanglements. The findings not only provide novel insights into this fundamental biological mechanism but also have potential practical applications. Gyrases are biomedical targets for the treatment of bacterial infections and the similar human versions of the enzymes are targets for many anti-cancer drugs. Better understanding of how gyrases work at the molecular level can potentially improve clinical treatments.
Published Genetic underpinnings of environmental stress identified in model plant
(via sciencedaily.com) Original source Researchers have identified 14 genes that thale cress -- a plant commonly used in genetic investigations since its genome is well documented -- express more when responding to five specific stressors, as well as eight genes that the plant suppresses.
Published Geobiology: New placozoan habitat discovered
(via sciencedaily.com) Original source Traces of DNA in the stomachs of predatory snails give a team og geobiologists new insights into the ecology of placozoans.
Published The genesis of our cellular skeleton, image by image
(via sciencedaily.com) Original source Cells contain various specialized structures -- such as the nucleus, mitochondria or peroxisomes -- known as 'organelles'. Tracing their genesis and determining their structure is fundamental to understanding cell function and the pathologies linked to their dysfunction.
Published Researchers discover how we perceive bitter taste
(via sciencedaily.com) Original source A new study reveals the detailed protein structure of the TAS2R14, a bitter taste receptor that allows us to perceive bitter taste. In addition to solving the structure of this taste receptor, the researchers were also able to determine where bitter-tasting substances bind to TAS2R14 and how they activate them. The findings may lead to the development of drugs that targeting taste receptors.
Published Cockayne syndrome: New insights into cellular DNA repair mechanism
(via sciencedaily.com) Original source Researchers decode repair mechanism during transcription of genetic information.
Published Machine learning method reveals chromosome locations in individual cell nucleus
(via sciencedaily.com) Original source Researchers have made a significant advancement toward understanding how the human genome is organized inside a single cell. This knowledge is crucial for analyzing how DNA structure influences gene expression and disease processes.
Published New diagnostic tool achieves accuracy of PCR tests with faster and simpler nanopore system
(via sciencedaily.com) Original source A new diagnostic tool developed by researchers can test for SARS-CoV-2 and Zika virus with the same or better accuracy as high-precision PCR tests in a matter of hours.
Published Different means to the same end: How a worm protects its chromosomes
(via sciencedaily.com) Original source Researchers have discovered that a worm commonly used in the study of biology uses a set of proteins unlike those seen in other studied organisms to protect the ends of its DNA.
Published Toothed whale echolocation organs evolved from jaw muscles
(via sciencedaily.com) Original source Genetic analysis finds evidence suggesting that acoustic fat bodies in the heads of toothed whales were once the muscles and bone marrow of the jaw.
Published Bringing multidrug-resistant pathogens to their knees
(via sciencedaily.com) Original source Multidrug-resistant bacterial infections that cannot be treated by any known antibiotics pose a serious global threat. A research team has now introduced a method for the development of novel antibiotics to fight resistant pathogens. The drugs are based on protein building blocks with fluorous lipid chains.
Published Integrated dataset enables genes-to-ecosystems research
(via sciencedaily.com) Original source A new dataset bridging molecular information about the poplar tree microbiome to ecosystem-level processes has been released. The project aims to inform research regarding how natural systems function, their vulnerability to a changing climate, and ultimately how plants might be engineered for better performance as sources of bioenergy and natural carbon storage.
Published Can language models read the genome? This one decoded mRNA to make better vaccines
(via sciencedaily.com) Original source Researchers developed a foundational language model to decode mRNA sequences and optimize those sequences for vaccine development. The tool shows broader promise as a means for studying molecular biology.
Published Rusty-patched bumblebee's struggle for survival found in its genes
(via sciencedaily.com) Original source The rusty-patched bumblebee, once common in the United States, has declined from about 90% of its former range. Researchers conducted the first range-wide genetic study of the endangered species to inform recovery efforts.
Published Heat flows the secret to order in prebiotic molecular kitchen
(via sciencedaily.com) Original source Biophysicists have demonstrated how heat flows through rock fissures could have created the conditions for the emergence of life.
Published New tools reveal how genes work and cells organize
(via sciencedaily.com) Original source Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these protein-RNA interactions. The newfound ability to predict these interactions can help future work in understanding molecular pathways in the cell and pave the way for developing drugs targeting these RNA G-quadruplex binding proteins, that are found to be involved in disease such as cancer.