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Categories: Biology: Genetics, Physics: Acoustics and Ultrasound

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Findings can open up new avenues for targeted approaches toward therapeutic strategies against the malaria-causing P. falciparum that are aimed at stopping the parasite's life cycle progression and its sexual differentiation, thus blocking the transmission of the parasite into mosquitoes.

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The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.

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A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression.

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Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.

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Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.

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In a groundbreaking endeavor, researchers have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan. The research opens exciting possibilities for unlocking the secrets of aging and extending human lifespan.

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Researchers study the impact of hearing loss on subjects' enjoyment of different music mixes. They played different music mixes to listeners with and without hearing loss and found that those with hearing loss preferred louder lead vocals, higher frequencies, and sparser mixes with fewer frequencies overall. Previous research has found that music steadily shifted to quieter vocals and louder instrumentals leading up to 1975, meaning today's music may be less accessible to those with hearing loss.

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For those with neurological or developmental disorders compromising speech, brain machine interfaces could help them communicate. But today's interfaces are slow and, from electrodes placed on the scalp, can detect letters only. The speech generated is robotic and affectless. Neuroscientists have now shown that they can reconstruct the song a person is hearing from brain recordings alone, holding out the possibility of reconstructing not only words but the musicality of speech, which also conveys meaning.

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In hopes of improving the survival rate for breast cancer patients, researchers designed a wearable ultrasound device that could allow women to detect tumors when they are still in early stages.

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Physicists have succeeded in making a new imaging technique ready for use on humans. Radioactive markers and radiation are not necessary for this.

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Routing signals and isolating them against noise and back-reflections are essential in many practical situations in classical communication as well as in quantum processing. In a theory-experimental collaboration, a team has achieved unidirectional transport of signals in pairs of 'one-way streets'. This research opens up new possibilities for more flexible signaling devices.

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Any sound can now be perfectly replicated by a combination of whistles, clicks, and hisses, with implications for sound processing across the media landscape.

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A new soft robotic glove is lending a 'hand' and providing hope to piano players who have suffered a disabling stroke or other neurotrauma. Combining flexible tactile sensors, soft actuators and AI, this robotic glove is the first to 'feel' the difference between correct and incorrect versions of the same song and to combine these features into a single hand exoskeleton. Unlike prior exoskeletons, this new technology provides precise force and guidance in recovering the fine finger movements required for piano playing and other complex tasks.

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In its simplest form, popcorn is pretty uncomplicated. Most supermarket varieties offer the choice of two kernel colors, yellow or white, and two kernel shapes, pointed or pearl. When popped, the flake typically expands into one of two shapes: mushroom or butterfly. But there's more to popcorn than meets the eye. New research reveals a wealth of untapped diversity lurking in popcorn's genetic code.

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Computer scientists have discovered a method of attack that can successfully bypass voice authentication security systems with up to a 99% success rate after only six tries.

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Acoustic waves may be able to control how particles sort themselves. While researchers have been able to separate particles based on their shape -- for example, bacteria from other cells -- for years, the ability to control their movement has remained a largely unsolved problem, until now. Using ultrasound technology and a nozzle, researchers have separated, controlled and ejected different particles based on their shape and various properties.

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A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies. Called the viral load, this is what is measured to allow clinicians to understand how patients are responding to anti-viral medications and monitor potential progression. The time-consuming viral load testing needs to be repeated several times as a patient undergoes treatment. Now, a research team has developed a time and cost-efficient digital assay that can directly measure the presence of HIV in single drop of blood.

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Short exposure to wind farm and road traffic noise triggers a small increase in people waking from their slumber that can fragment their sleep patterns, according to new research. But importantly, the new study also shows that wind farm noise isn't more disruptive to sleep than road traffic, which was a little more disruptive at the loudest audio level but not at more common levels. Sleep researchers have studied the impact of exposure to wind farm noise during sleep in three new scientific publications to better understand its impact.

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Similar to the expeditions of a hundred or two hundred years ago, the Tara Pacific expedition lasted over two years. The goal: to research the conditions for life and survival of corals. The ship crossed the entire Pacific Ocean, assembling the largest genetic inventory conducted in any marine system to date. The team's 70 scientists from eight countries took around 58,000 samples from the hundred coral reefs studied.

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The Bachman's warbler, a songbird that was last seen in North America nearly 40 years ago, was a distinct species and not a hybrid of its two living sister species, according a new study in which the full genomes of seven museum specimens of the bird were sequenced.