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Categories: Biology: Genetics, Computer Science: Quantum Computers

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Scientists have amassed genome data for dozens of 'magic mushroom' isolates and cultivars, with the goal to learn more about how their domestication and cultivation has changed them. The findings may point the way to the production of intriguing new cultivars, say the researchers.

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While we often think of diseases as caused by foreign bodies -- bacteria or viruses -- there are hundreds of diseases affecting humans that result from errors in cellular production of its proteins. A team of researchers recently leveraged the power of cutting-edge technology, including an innovative technique called glycoproteomics, to unlock the carbohydrate-based code that governs how certain classes of proteins form themselves into the complex shapes necessary to keep us healthy.

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Researchers have developed a new technique called MAbID. This allows them to simultaneously study different mechanisms of gene regulation, which plays a major role in development and disease. MAbID offers new insights into how these mechanisms work together or against each other.

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Scientists sequenced the genome of the East Asian pitcher plant, Nepenthes gracilis, a species of carnivorous plant related to Venus flytraps, as well as sundews, beets and spinach.

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Maize is one of the world's most widely grown crops. It is used for both human and animal foods and holds great cultural significance, especially for indigenous peoples in the Americas. Yet despite its importance, the origins of the grain have been hotly debated for more than a century. Now new research shows that all modern maize descends from a hybrid created just over 5000 years ago in central Mexico, thousands of years after the plant was first domesticated.

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Long before researchers discovered the electron and its role in generating electrical current, they knew about electricity and were exploring its potential. One thing they learned early on was that metals were great conductors of both electricity and heat. And in 1853, two scientists showed that those two admirable properties of metals were somehow related: At any given temperature, the ratio of electronic conductivity to thermal conductivity was roughly the same in any metal they tested. This so-called Wiedemann-Franz law has held ever since -- except in quantum materials. Now, a theoretical argument put forth by physicists suggests that the law should, in fact, approximately hold for one type of quantum material, the cuprate superconductors.

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Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.

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New research identifies the class II PI3K-C2b protein, a member of the PI3 family of kinases, as one of the key regulators of blood vessels growth in humans and other mammals. Mutations in these family of proteins may lead to vascular malformations and the precise understanding of the whole process is instrumental in opening the door to new therapeutic approaches in the future.

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Fruit and vegetables contain a variety of plant natural products such as flavonoids, which give fruits their colour and are said to have health-promoting properties. Most plant natural products occur in nature as glycosides, i.e. chemical compounds with sugars. In order for humans to absorb the healthy plant natural products, the sugar must be split off in the intestine. Microorganisms in the intestinal flora help to speed up the process. So-called C-glycosides, i.e. plant natural products with a carbon-based bond to a sugar, would even be practically indigestible without the intestinal microbes (e.g. nothofagin in rooibos tea).

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Enzymes from microorganisms can produce hydrogen (H2) under certain conditions, which makes them potential biocatalysts for biobased H2 technologies. In order to make this hydrogen production efficient, researchers are trying to identify and eliminate possible limiting factors. These include formaldehyde, which occurs naturally as a metabolic product in cells and inhibits the particularly efficient [FeFe] hydrogenase.

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Bees, wasps and ants belong to the Hymenoptera order and inject a whole cocktail of venomous ingredients when they sting. Despite their tremendous ecological and economic importance, little was previously known about the origins of their venom. Through extensive genomic studies, a team of researchers has now discovered that typical venomous components were already present in the earliest ancestors of Hymenoptera and must therefore have evolved before the stingers of bees and other insects. What's more, and contrary to previous assumptions, the gene for the venom melittin is found solely in bees.

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Scientists have developed a new tool for the measurement of entanglement in many-body systems and demonstrated it in experiments. The method enables the study of previously inaccessible physical phenomena and could contribute to a better understanding of quantum materials.

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The evolution of higher cognitive functions in humans has so far mostly been linked to the expansion of the neocortex. Researchers are increasingly realizing, however, that the 'little brain' or cerebellum also expanded during evolution and probably contributes to the capacities unique to humans. A research team has now generated comprehensive genetic maps of the development of cells in the cerebella of human, mouse and opossum. Comparisons of these maps reveal both ancestral and species-specific cellular and molecular characteristics of cerebellum development.

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Researchers have developed a way of joining up the head and tail of a protein, making it more stable and easier to get into cells.

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A new kind of 'wire' for moving excitons could help enable a new class of devices, perhaps including room temperature quantum computers.

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A new study suggests that E. coli bacteria may have a higher capability to evolve antibiotic resistance than previously believed. Researchers mapped possible mutations in an essential E. coli protein involved in antibiotic resistance and found that 75% of evolutionary paths led to high antibiotic resistance, challenging existing theories about fitness landscapes in evolutionary biology. This discovery may have broader implications for understanding adaptation and evolution in various fields.

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Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a new study.

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Researchers report that they have found a way to get antibacterial drugs through the nearly impenetrable outer membrane of Pseudomonas aeruginosa, a bacterium that -- once it infects a person -- is notoriously difficult to treat.

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A new software tool with enhanced genome-sequencing powers has been developed, increasing the speed and accuracy at which researchers can improve plants through breeding.

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Some enzymes, such as the one derived from fungi and investigated in this study, are able to produce valuable substances such as the fragrance (R)-1-phenylethanol. To this end, they convert a less expensive substrate using a co-substrate. A research team came up with the idea of supplying them with this co-substrate using a plasma -- a somewhat crazy idea, as plasmas generally have a destructive effect on biomolecules. However, by employing several tricks, the researchers did indeed succeed. They have now refined one of these tricks and thus improved the process: They attach the enzymes to tiny beads in order to hold them in place at the bottom of the reactor, where they are protected from the damaging effects of the plasma.