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Categories: Biology: Genetics, Mathematics: Puzzles
Published Genomic research may help explain cancer resistance in Tasmanian devils
(via sciencedaily.com) Original source Through DNA sequencing of Tasmanian devils and their tumors, researchers have tracked the genomic interactions between the animals and the cancer.
Published Researchers discover key gene for toxic alkaloid in barley
(via sciencedaily.com) Original source Barley is one of the most important cereal crops on a global scale. Many barley cultivars produce a toxic alkaloid called gramine that affects the suitability of barley as fodder, but also helps to protect barley from pathogens. So far, the potential of manipulating gramine levels has not been harnessed for plant breeding, because the genetic basis of gramine production has been unresolved. Research groups now disclose the complete biosynthetic pathway of gramine and demonstrate how gramine biosynthesis can be introduced into model organisms or removed from barley.
Published Cell division quality control 'stopwatch' uncovered
(via sciencedaily.com) Original source Biologists have uncovered a quality control timing mechanism tied to cell division. The 'stopwatch' function keeps track of mitosis and acts as a protective measure when the process takes too long, preventing the formation of cancerous cells.
Published Connecting the dots to shape growth forces
(via sciencedaily.com) Original source Branching patterns are prevalent in our natural environment and the human body, such as in the lungs and kidneys. For example, specific genes that express growth factor proteins are known to influence the development of the lungs' complex branches. Researchers have unveiled a regulatory system linking signal, force, and shape in mouse lung structure development. The team recognized that the signal protein ERK plays an active role in causing growing lung tissue to curve.
Published Sweet success: Sugarcane's complex genetic code cracked
(via sciencedaily.com) Original source Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants. Exploring sugarcane's genetic code could help researchers develop more resilient and productive crops, with implications for both sugar production and biofuels.
Published Scientists extract genetic secrets from 4,000-year-old teeth to illuminate the impact of changing human diets over the centuries
(via sciencedaily.com) Original source Researchers have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.
Published New technique for predicting protein dynamics may prove big breakthrough for drug discovery
(via sciencedaily.com) Original source Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them. To that end, a team of researchers has developed a way of using machine learning to rapidly predict multiple protein configurations to advance understanding of protein dynamics and functions.
Published Severe hurricanes boost influx of juveniles and gene flow in a coral reef sponge
(via sciencedaily.com) Original source A study is the first to evaluate substrate recolonization by sponges in the U.S. Virgin Islands after two catastrophic storms using genetic analyses to understand how much clonality verses sexual recruitment occurs on coral reefs post-storms. Results show that populations of clonal marine species with low pelagic dispersion, such as A. cauliformis, may benefit from increased frequency and magnitude of hurricanes to maintain genetic diversity and combat inbreeding, enhancing the resilience of Caribbean sponge communities to extreme storm events.
Published Discovery of amino acid unveils how light makes plants open
(via sciencedaily.com) Original source Scientists have uncovered a unique mechanism that regulates the opening of stomata in plants. Phosphorylation of the amino acid Thr881 on the plasma membrane proton pump plays a key role in this process. The study paves the way for the targeted manipulation of plant physiology, with potential applications in agriculture and environmental sustainability.
Published Humans pass more viruses to other animals than we catch from them
(via sciencedaily.com) Original source Humans pass on more viruses to domestic and wild animals than we catch from them, according to a major new analysis of viral genomes.
Published Natural recycling at the origin of life
(via sciencedaily.com) Original source How was complex life able to develop on the inhospitable early Earth? At the beginning there must have been ribonucleic acid (RNA) to carry the first genetic information. To build up complexity in their sequences, these biomolecules need to release water. On the early Earth, which was largely covered in seawater, that was not so easy to do.
Published As we age, our cells are less likely to express longer genes
(via sciencedaily.com) Original source Aging may be less about specific 'aging genes' and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers. A decline in the expression of long genes with age has been observed in a wide range of animals, from worms to humans, in various human cell and tissue types, and also in individuals with neurodegenerative disease. Mouse experiments show that the phenomenon can be mitigated via known anti-aging factors, including dietary restriction.
Published Maize genes control little helpers in the soil
(via sciencedaily.com) Original source Tiny organisms such as bacteria and fungi help to promote the health and function of plant roots. It is commonly assumed that the composition of these microbes is dependent on the properties of the soil. However, researchers have now discovered when studying different local varieties of maize that the genetic makeup of the plants also helps to influence which microorganisms cluster around the roots.
Published Decoding the plant world's complex biochemical communication networks
(via sciencedaily.com) Original source A research team has begun translating the complex molecular language of petunias. Their grammar and vocabulary are well hidden, however, within the countless proteins and other compounds that fill floral cells. Being rooted to the ground, plants can't run away from insects, pathogens or other threats to their survival. But plant scientists have long known that they do send warnings to each other via scent chemicals called volatile organic compounds.
Published Scientists weigh up current status of blue whale populations around the world
(via sciencedaily.com) Original source The largest living animal, the blue whale (Balaenoptera musculus) which averages about 27 meters in length, has slowly recovered from whaling only to face the rising challenges of global warming, pollution, disrupted food sources, shipping, and other human threats. In a major new study, biologists have taken a stock of the number, distribution and genetic characteristics of blue whale populations around the world and found the greatest differences among the eastern Pacific, Antarctic subspecies and pygmy subspecies of the eastern Indian and western Pacific.
Published Decoding the Easter Bunny -- an eastern Finnish brown hare to represent the standard for the species' genome
(via sciencedaily.com) Original source Biologists have published a chromosomally assembled reference genome for the European brown hare. The genome consists of 2.9 billion base pairs, which form 23 autosomal chromosomes, and X and Y sex chromosomes. The timing of the genome release is very appropriate as the brown hare also represents the original Easter Bunny familiar from European folklore.
Published Across oceans and millennia: decoding the origin and history of the bottle gourd
(via sciencedaily.com) Original source Researchers have uncovered intriguing details about the origins and spread of the bottle gourd, one of the oldest domesticated crops. Their work unveils the genetic diversification and population history of this hard-shelled plant that was used to make bottles, instruments, and containers for over 10,000 years by ancient civilizations.
Published Fiber, genes and the gut microbiome: Study reveals possible triggers for inflammatory bowel disease
(via sciencedaily.com) Original source A new study finds a complex interplay between diet, genes, and the gut microbiota that could explain why IBD develops.
Published Empty 'backpacks' activate the immune system against cancer
(via sciencedaily.com) Original source Researchers have discovered that the mere act of attaching their microparticle 'backpacks' to neutrophils is enough to activate them against cancer -- no drugs needed. In experiments, backpack-bearing neutrophils shrank tumors and extended the survival of mice with cancer, and treated animals retained an immune memory of the disease. This approach opens the door to a new class of drug-free immunotherapy for cancer.
Published A protein found in human sweat may protect against Lyme disease
(via sciencedaily.com) Original source Human sweat contains a protein that may protect against Lyme disease. About one-third of the population carries a genetic variant of this protein that is associated with Lyme disease in genome-wide association studies.