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Categories: Biology: Genetics, Mathematics: Modeling
Published T cells can activate themselves to fight tumors
(via sciencedaily.com) Original source Scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers.
Published New probe aids novel findings on cell functions
(via sciencedaily.com) Original source New research shows the use of a new cellular probe helped discover new findings about certain cellular processes.
Published An unprecedented view of gene regulation
(via sciencedaily.com) Original source Using a new technique, researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.
Published Elucidating the mysteries of enzyme evolution at the macromolecular level
(via sciencedaily.com) Original source Researchers have made a major breakthrough earlier this year in the field of evolutionary conservation of molecular dynamics in enzymes. Their work points to potential applications in health, including the development of new drugs to treat serious diseases such as cancer or to counter antibiotic resistance.
Published Scientist uncovers roots of antibiotic resistance
(via sciencedaily.com) Original source Microbiologists have uncovered the evolutionary origins of antimicrobial resistance (AMR) in bacteria. His studies on the bacterium that causes cholera, Vibrio cholerae, provide insight into deciphering what conditions must occur for infectious agents to become resistant. He studied genetic variants of a protein found in bacterial membranes called OmpU. Using computational and molecular approaches, his team found that several OmpU mutations in the cholera bacteria led to resistance to numerous antimicrobial agents. This resistance included antimicrobial peptides that act as defenses in the human gut.
Published AI could run a million microbial experiments per year
(via sciencedaily.com) Original source Automation uncovers combinations of amino acids that feed two bacterial species and could tell us much more about the 90% of bacteria that humans have hardly studied. An artificial intelligence system enables robots to conduct autonomous scientific experiments -- as many as 10,000 per day -- potentially driving a drastic leap forward in the pace of discovery in areas from medicine to agriculture to environmental science.
Published Gutless marine worms on a Mediterranean diet: Animals can synthesize phytosterols
(via sciencedaily.com) Original source Phytosterols are good for your health, but humans and other animals are not able to make them themselves, only plants can. To acquire phytosterols, humans are increasingly turning to supplements, green smoothies, or a Mediterranean diet with plenty of plant-based foods. Researchers have now discovered that tiny gutless worms from the Mediterranean can synthesize phytosterols on their own. Their study provides evidence that many other animals also have the genes needed to make their own phytosterols.
Published Alternative 'fuel' for string-shaped motors in cells
(via sciencedaily.com) Original source Researchers discover a unique two-component molecular motor that uses a kind of renewable chemical energy to pull vesicles toward membrane-bound organelles.
Published Scientists discover the dynamics of an 'extra' chromosome in fruit flies
(via sciencedaily.com) Original source Most chromosomes have been around for millions of years. Now, researchers have revealed the dynamics of a new, very young chromosome in fruit flies that is similar to chromosomes that arise in humans and is associated with treatment-resistant cancer and infertility. The findings may one day lead to developing more targeted therapies for treating these conditions.
Published A novel stem cell adhesive using mussels
(via sciencedaily.com) Original source A team of researchers develops stem cell adhesive for arthritis treatment using mussel adhesion protein and hyaluronic acid.
Published Scientists present evidence for a billion-years arms race between viruses and their hosts
(via sciencedaily.com) Original source Researchers have proposed a new evolutionary model for the origin of a kingdom of viruses called Bamfordvirae, suggesting a billion-years evolutionary arms race between two groups within this kingdom and their hosts.
Published Wiggly proteins guard the genome
(via sciencedaily.com) Original source Dynamic network in the pores of the nuclear envelope blocks dangerous invaders.
Published New research redefines mammalian tree of life
(via sciencedaily.com) Original source Scientists from around the globe are using the largest mammalian genomic dataset in history to determine the evolutionary history of the human genome in the context of mammalian evolutionary history. Their ultimate goal is to better identify the genetic basis for traits and diseases in people and other species.
Published Artificial photosynthesis for environmentally friendly food production
(via sciencedaily.com) Original source Ensuring the supply of food to the constantly growing world population and protecting the environment at the same time are often conflicting objectives. Now researchers have successfully developed a method for the synthetic manufacture of a nutritional protein using a type of artificial photosynthesis. The animal feed industry is the primary driver of high demand for large volumes of this nutritional protein L-alanine, which is also suitable for use in meat substitute products.
Published Structured exploration allows biological brains to learn faster than AI
(via sciencedaily.com) Original source Neuroscientists have uncovered how exploratory actions enable animals to learn their spatial environment more efficiently. Their findings could help build better AI agents that can learn faster and require less experience.
Published Scientists identify antivirals that could combat emerging infectious diseases
(via sciencedaily.com) Original source A new study has identified potential broad-spectrum antiviral agents that can target multiple families of RNA viruses that continue to pose a significant threat for future pandemics.
Published Scientists slow aging by engineering longevity in cells
(via sciencedaily.com) Original source Researchers have developed a biosynthetic 'clock' that keeps cells from reaching normal levels of deterioration related to aging. They engineered a gene oscillator that switches between the two normal paths of aging, slowing cell degeneration and setting a record for life extension.
Published Genomes from 240 mammal species explain human disease risks
(via sciencedaily.com) Original source Why is it that certain mammals have an exceptional sense of smell, some hibernate, and yet others, including humans, are predisposed to disease? A major international research project has surveyed and analyzed the genomes of 240 different mammals. The results show how the genomes of humans and other mammals have developed over the course of evolution. The research shows which regions have important functions in mammals, which genetic changes have led to specific characteristics in different species and which mutations can cause disease.
Published One famous dog and a powerful new approach for understanding biology and evolutionary history
(via sciencedaily.com) Original source Ever since scientists first read the complete genetic codes of creatures like fruit flies and humans more than two decades ago, the field of genomics has promised major leaps forward in understanding basic questions in biology. Two recent articles break new ground by showing how much valuable information can be found in genomes of a single species, such as endangered orcas, or even in the DNA of an individual. That individual is a sled dog named Balto, who has been immortalized in movies and a statue for helping to bring lifesaving diphtheria antitoxin to Nome, Alaska in an epic journey across the Alaskan wilderness in the winter of 1925. With just a snippet of the dog's preserved skin researchers have made great discoveries.
Published Pulling the plug on viral infections: CRISPR isn't just about cutting
(via sciencedaily.com) Original source CRISPR claimed scientific fame for its ability to quickly and accurately edit genes. But, at the core, CRISPR systems are immune systems that help bacteria protect themselves from viruses. A new study reveals a previously unrecognized player in one such system -- a membrane protein that enhances anti-viral defense. According to study authors, the finding upends the idea that CRISPR systems mount their defense only by degrading RNA and DNA in cells.