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Categories: Biology: Genetics, Mathematics: Modeling

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Researchers wanted to understand precisely how blackworms execute tangling and ultrafast untangling movements for a myriad of biological functions. They researched the topology of the tangles. Their research could inform the design of fiber-like, shapeshifting robotics that self-assemble and move in ways that are fast and reversible.

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What the human genome is lacking compared with the genomes of other primates might have been as crucial to the development of humankind as what has been added during our evolutionary history, according to a new study led by researchers at Yale and the Broad Institute of MIT and Harvard. The new findings, published April 28 in the journal Science, fill an important gap in what is known about historical changes to the human genome.

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Even though it is important to know where these variations are located in the genome, it's also useful to know how or why these genetic variations happened in the first place.

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Bacterial spores can survive for years, even centuries, without nutrients, resisting heat, UV radiation, and antibiotics. How inert, sleeping bacteria -- or spores -- spring back to life has been a century-long mystery. New research identifies how sensor proteins revive dormant bacteria. Discovery opens new routes to combat spore resistance to antibiotics and sterilization. Findings can inform novel strategies to prevent infections, food spoilage.

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New research suggests future Martian botanists may be able to grow gene-edited rice on Mars.

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Typically T cells of the immune system respond to a specific feature (antigen) of a microbe, thereby generating protective immunity. Scientists have discovered an exception to this rule. Namely, a group of divergent bacterial pathogens, including pneumococci, all share a small highly conserved protein sequence, which is both presented and recognized by human T cells in a conserved population-wide manner.

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Viruses like influenza A and Ebola invade human cells in a number of steps. Research teams investigated the final stages of viral penetration using electron tomography and computer simulations. So-called fusion pores, through which the viral genome is released into the host cell, play a central role in these processes. If they can be prevented from forming, the virus is also blocked. The Heidelberg scientists describe previously unknown mechanisms, which might lead to new approaches to prevent infections.

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Researchers develop an early warning system that combines acoustic technology with AI to immediately classify earthquakes and determine potential tsunami risk. They propose using underwater microphones, called hydrophones, to measure the acoustic radiation produced by the earthquake, which carries information about the tectonic event and travels significantly faster than tsunami waves. The computational model triangulates the source of the earthquake and AI algorithms classify its slip type and magnitude. It then calculates important properties like effective length and width, uplift speed, and duration, which dictate the size of the tsunami.

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The study is the first to identify a damage response pathway that is distinct from but parallel to the classical pathway triggered by pathogens.

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A team of physicists has illuminated certain properties of quantum systems by observing how their fluctuations spread over time. The research offers an intricate understanding of a complex phenomenon that is foundational to quantum computing.

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A research team has confirmed evidence of a previously unknown planet outside of our solar system, and they used machine learning tools to detect it. A recent study by the team showed that machine learning can correctly determine if an exoplanet is present by looking in protoplanetary disks, the gas around newly formed stars. The newly published findings represent a first step toward using machine learning to identify previously overlooked exoplanets.

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An international team of researchers lays the foundation to examine how extracellular RNA and its carrier proteins found in bodily fluids function in a healthy as well as a diseased setting, potentially providing a means to accurately implement early detection and monitor disease processes.

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An AI strategy proven adept at board games like Chess and Go, reinforcement learning, has now been adapted for a powerful protein design program. The results show that reinforcement learning can do more than master board games. When trained to solve long-standing puzzles in protein science, the software excelled at creating useful molecules. In one experiment, proteins made with the new approach were found to be more effective at generating useful antibodies in mice than were previous methods. If this method is applied to the right research problems, it likely could accelerate progress in a variety of scientific fields.

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Evolution of two contagious cancers affecting Tasmanian devils underlines unpredictability of disease threat. Scientists have traced the family trees of two transmissible cancers that affect Tasmanian devils and have pinpointed mutations which may drive growth of deadly diseases.

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An essential pillar of Earth's ecological system, fungi have long been used to better the lives of humans. While these organisms are still vastly understudied, a new review paper suggests that their unique genomes could be used to make progress in the biotech industry.

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A new machine-learning system can generate protein designs with certain structural features, and which do not exist in nature. These proteins could be utilized to make materials that have similar mechanical properties to existing materials, like polymers, but which would have a much smaller carbon footprint.

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Investigators are developing a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using engineered stem cells that may eventually lead to personalized treatments.

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What if, by adding a couple of cell layers inside a corn kernel, the grain could become significantly richer in essential nutrients like iron, zinc, and protein? Such an improvement could benefit people who rely on corn for a large portion of their diet, as in many parts of the global south.

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Certain stem cells have a unique ability to move between growth compartments in hair follicles, but get stuck as people age and so lose their ability to mature and maintain hair color, a new study shows.

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Two protein complexes carry the major responsibility for the spatial organization of chromosomes in our cell nuclei. DNA tension plays a surprising role in this. Nanoscientists now publish how they have visualized this.