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Categories: Biology: Genetics, Mathematics: Modeling
Published New mechanism for DNA folding
(via sciencedaily.com) Original source A hitherto unknown mechanism for DNA folding is described in a new study. The findings provide new insights into chromosomal processes that are vital to both normal development and to prevent disease.
Published Novel nanocages for delivery of small interfering RNAs
(via sciencedaily.com) Original source Small interfering RNAs (siRNAs) are novel therapeutics that can be used to treat a wide range of diseases. This has led to a growing demand for selective, efficient, and safe ways of delivering siRNA in cells. Now, in a cooperation between the Universities of Amsterdam and Leiden, researchers have developed dedicated molecular nanocages for siRNA delivery. In a paper just out in the Journal Chem they present nanocages that are easy to prepare and display tuneable siRNA delivery characteristics.
Published SpyLigation uses light to switch on proteins
(via sciencedaily.com) Original source Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study and control them in more detail. This technology has potential uses in tissue engineering, regenerative medicine, and understanding how the body works. The scientists applied their new method to control the glow of a green fluorescent protein derived from Japanese eel muscle.
Published Quantum liquid becomes solid when heated
(via sciencedaily.com) Original source Solids can be melted by heating, but in the quantum world it can also be the other way around: An experimental team has shown how a quantum liquid forms supersolid structures by heating. The scientists obtained a first phase diagram for a supersolid at finite temperature.
Published New genetic target for male contraception identified
(via sciencedaily.com) Original source Discovery of a gene in multiple mammalian species could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals. Researchers identified expression of the gene, Arrdc5, in the testicular tissue of mice, pigs, cattle and humans. When they knocked out the gene in mice, it created infertility only in the males, impacting their sperm count, movement and shape.
Published Molecular 'Superpower' of antibiotic-resistant bacteria
(via sciencedaily.com) Original source A species of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics. Since the bacteria is naturally resistant to many antibiotics, it causes problems, particularly in healthcare settings. A study now shows how two molecular mechanisms can work together make the bacterium extra resistant.
Published Software to untangle genetic factors linked to shared characteristics among different species
(via sciencedaily.com) Original source Scientists have developed a software package to help answer key questions about genetic factors associated with shared characteristics among different species.
Published How a virus causes chromosomal breakage, leading to cancer
(via sciencedaily.com) Original source Researchers describe how the Epstein-Barr virus exploits genomic weaknesses to cause cancer while reducing the body's ability to suppress it.
Published Where did the first sugars come from?
(via sciencedaily.com) Original source Origin-of-life chemists propose that glyoxylate could have been the original source of sugars on the 'prebiotic' Earth
Published Hairs that help fish feel -- and humans hear
(via sciencedaily.com) Original source Scientists are reporting a discovery about unexpected asymmetry on the hair cells of zebrafish that allow them to detect movement with greater sensitivity from the back than the front.
Published Biologists determine the evolutionary age of individual cell types providing critical insights for animal development
(via sciencedaily.com) Original source A research team has recently made a significant discovery about the evolutionary age of different type of cells in a small animal called Caenorhabditis elegans (C. elegans). By using single-cell transcriptomic data and refined phylostratigraphy, the team determines the transcriptomic age of individual cells, which means they are able to estimate the evolutionary origin of different cells based on the age of the genes expressed in the cells.
Published How skates learned to fly through water
(via sciencedaily.com) Original source Genes are not the only drivers of evolution. The iconic fins of skates are caused by changes in the non-coding genome and its three-dimensional structure, an international research team reports.
Published Oral barrier is similar in ceramide composition to skin barrier
(via sciencedaily.com) Original source Acylceramides and protein-bound ceramides are vital for the formation of the oral barrier in mice, similar to their role in skin, protecting from infection.
Published Genes are read faster and more sloppily in old age
(via sciencedaily.com) Original source Scientists have demonstrated the following findings which apply across the animal kingdom: with increasing age, the transcriptional elongation speed of genes increases, whereby the quality of the gene products suffers. With dietary restrictions, these processes could be reversed.
Published British flower study reveals surprise about plants' sex life
(via sciencedaily.com) Original source A study of Britain's native flowering plants has led to new insights into the mysterious process that allows wild plants to breed across species -- one of plants' most powerful evolutionary forces. When wild flowering plants are sizing up others they may often end up in a marriage between close relatives rather than neighbors, a new study has revealed.
Published Stowaways in the genome
(via sciencedaily.com) Original source Scientists have discovered over 30,000 viruses by using the high-performance computer cluster 'Leo' and sophisticated detective work. The viruses hide in the DNA of unicellular organisms. In some cases, up to 10% of microbial DNA consists of built-in viruses.
Published Male yellow crazy ants are real-life chimeras
(via sciencedaily.com) Original source Researchers discovered that males of the yellow crazy ant have maternal and paternal genomes in different cells of their body and are thus chimeras.
Published Your baby's gut is crawling with unknown viruses
(via sciencedaily.com) Original source Babies tumble about with more than 200 previously unknown viral families within their intestines. This large number comes as a surprise to researchers, who closely studied the diapers of 647 Danish babies and made this mapping. These viruses most likely play an important role in protecting children from chronic diseases.
Published Rooting out how plants control nitrogen use
(via sciencedaily.com) Original source Nitrogen is such a crucial nutrient for plants that vast quantities of nitrogen-containing fertilizers are spread on farmlands worldwide. However, excess nitrogen in the soil and in drainage run-off into lakes and rivers causes serious ecological imbalances. A recent study has uncovered the regulatory mechanisms at work when plants utilize nitrogenous fertilizers in their roots, a positive step in the quest to generate crops that require less fertilizer while still producing the yields needed to feed the world.
Published Engineered plants produce sex perfume to trick pests and replace pesticides
(via sciencedaily.com) Original source Tobacco plants have been engineered to manufacture an alluring perfume of insect sex pheromones, which could be used to confuse would-be pests looking for love and reduce the need for harmful pesticides.